BOSTON PEPPER CENTER
Claude D. Pepper Older Americans Independence Center

Principal Investigator (Brigham and Women’s Hospital Harvard Medical School)    Shalender Bhasin, M.D.  .  sbhasin@partners.org
Co-PI (Tufts University School of Medicine)    Roger Fielding, PhD  .  rfield01@granite.tufts.edu
Co-PI (Beth Israel Deaconess Medical Center Hebrew SeniorLife Harvard Medical School)    Lewis A. Lipsitz, MD  .  lipsitz@hsl.harvard.edu
Program Administrator    Molly Lukas  .  mlukas@bwh.harvard.edu
       
CENTER DESCRIPTION

The Boston OAIC is unique in its thematic focus on Function Promoting Therapies (FPTs) and its positioning across the entire spectrum of translational science from mechanism elucidation, preclinical proof-of-concept studies, biomarker validation, epidemiologic investigation to randomized trials of FPTs. The Boston OAIC integrates 19 NIH-funded studies of function promoting therapies, 3 Research Education Component projects, 3 pilot projects, and 3 developmental projects into an interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Education Component (REC), a Pilot and Exploratory Studies Core (PESC), and 3 resource cores (Function Assessment Core, Preclinical Discovery Core, Biostatistical and Data Analysis Core). Our REC and PESC candidates include several rising stars in Geriatrics and Gerontology, including 3 Beeson and K grant awardees. The REC will recruit the most promising stars from a vast reservoir of talent at Harvard, Tufts and BU, and train them through a didactic education and mentored research program. Integration will be achieved by the PROMOTE Program that includes a research concierge service, research meetings, annual retreats, a website and a newsletter. The Boston OAIC is well integrated with the the Harvard Geriatrics and Gerontology research community and programs, including its T32 training grant, Harvard Clinical Translational Science Institute, the Roybal Center, The New England Geriatrics Research Clinical Education Center, and the Glenn Foundation Center for Biology of Aging.

Boston OAIC’s unique strengths include its focus on Function Promoting Therapies, emphasis on translation and commercialization, access to a large pool of talented young investigators, its extension across the entire spectrum of translational research, and its infrastructure for developing intellectual property and companies, and supporting several seminal randomized trials of FPTs.


CORES
Leadership and Administrative Core (LAC)
Leader 1:    Shalender Bhasin, MD   sbhasin@partners.org
Leader 2:    Roger Fielding, PhD   
Leader 3:    Lewis A. Lipsitz, MD   lipsitz@hsl.harvard.edu
The LAC is responsible for stimulating, sustaining, evaluating, and reporting OAIC’s progress towards its goals and enabling integration of OAIC activities. In addition to providing administrative support, the LAC coordinates the activities of Boston OAIC’s investigators, resource cores, its conferences, and career development activities.

Research Education Component (REC)
Leader 1:    Lewis A. Lipsitz, MD   lipsitz@hsl.harvard.edu
Leader 2:    Amy Wagers, PhD   
Leader 3:    Edward Marcantonio, MD   
The overall goal of the Research Education Component (REC) of the Boston OAIC is to train future independent research scientists who have the knowledge and the skill to translate fundamental mechanisms of disease and disability into novel interventions that can improve the health, physical function, and well-being of people as they age. The REC achieves this by selecting the most promising early career scientists from clinical and basic science disciplines and providing them with both collective and individual educational activities, research experiences, mentoring, and career guidance that will enable them to acquire future career development or research awards and ultimately become leaders in translational research devoted to the discovery of function promoting therapies (FPTs).

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Monty Montano, PhD   MMONTANO@bwh.harvard.edu
Leader 2:    Douglas P. Kiel, MD   
Within the context of the OAIC’s overall mission, the Pilot and Exploratory Studies Core (PESC) aims to provide catalytic support – seed funding, core support, and mentorship – for innovative pilot research projects that generate data on the mechanisms of FPT action to facilitate more definitive mechanistic studies, feasibility data to guide efficacy trials, hypothesis generating or proof-of-concept exploratory studies and retrospective analysis of existing epidemiologic data that inform FPT interventions.

Biostatistical Design and Analysis Core (BDAC)
Leader 1:    Thomas Travison, PhD   TGT@hsl.harvard.edu
Leader 2:    Paola Sebastiani, PhD   
Leader 3:    Karol Pencina, PhD   
The BDAC provides collaborative support in the design, execution and analysis of clinical trials and epidemiology studies conducted at the Boston OAIC. Additionally, the BDAC provides mentoring and collaborative opportunities for students and junior faculty in quantitative aspects of the study of physical function and impairments in aging. The BDAC is equipped to provide critical services on a consulting basis (e.g. in an advisory capacity in critical review of study data collection procedures) and more formally (e.g. in conducting simulation studies and power calculation). Furthermore, the BDAC provides support for ongoing projects by providing critical review and expertise in evaluating study conduct, or more extensive, pre-specified contributions to trial objectives. Support services for study completion are also available in providing guidance and assistance in statistical analyses, as well as co-authorship of abstracts and manuscripts describing study results.

Development Projects Core
Leader 1:    Shalender Bhasin, MD   sbhasin@bwh.harvard.edu
The Developmental Projects core funds pilot projects chosen based on their innovation and translational value, and the need and potential of novel methods to advance OAIC projects

Functional Assessment Core (FAC)
Leader 1:    Roger Fielding, PhD   roger.fielding@tufts.edu
Leader 2:    Thomas Storer, Ph.D.   
The FAC represents a strategic interdisciplinary alliance between the Muscle Mechanics and Metabolomics Laboratory, the Laboratory of Exercise Physiology and Physical Performance and the Health and Disability Research Institute at Boston University and the Nutrition, Exercise Physiology and Sarcopenia Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. The core provides standardized, state-of-the-art technologies to measure muscle performance, functional limitations, and disability in human and animal studies for OAIC’s pilot and exploratory projects and for several OAIC related projects funded through other sources.

Preclinical Discovery care
Leader 1:    Ravi Jasuja, PhD   
The ability to genetically modify rodents has increased the need to assess reproducibly and quantifiably, the phenotype of these animals with respect to body composition and physical function. In addition to utilizing the small animal resource services, the Preclinical Discovery Core (PDC) provides the infrastructural and consultative support for non-invasive measurements of alterations in body composition, muscle performance, physical function and metabolic performance to facilitate longitudinal studies of FPTs during aging and metabolic stress. The PDC is also continuing its mission to spearhead innovation- development of novel 7Tesla MRI techniques to provide mechanistic insights into FPT interventions.

CAREER DEVELOPMENT
REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications
 
Jason Sanders, MD
Fellow / Harvard Medical School
Clinical fellow
2020-2021  46 (20 1st/Sr)
Abdala Elkhal, PhD
Staff Scientist / Harvard Medical School
Assistant Professor (pending)
2020-2021  49 (3 1st/Sr)
Daniel Roh, MD
Assistant Professor / Boston University
Assistant Professor
2021-2022  20 (10 1st/Sr)
Sari Reisner, DSc.
Assistant Professor / Harvard Medical School
Assistant Professor
2021-2022  165 (50 1st/Sr)
Sanjay Divakaran, MD
Instructor / Harvard Medical School
Instructor
2021-2022  41 (12 1st/Sr)
Timothy Anderson, MD
Instructor / Harvard Medical School
Instructor
2021-2022  32 (20 1st/Sr)
Clark DuMontier, MD
Geriatrician, Fellow / Harvard Medical School
Geriatrician, Fellow
2021-2022  20 (8 1st/Sr)

Past Scholars

PILOT/EXPLORATORY PROJECTS (7 Pilot Projects Listed)
1. Project Title: REC-2: Integrating Feasible and Valid Functional Outcomes in Older Patients with Multiple Myeloma Undergoing Chemotherapy.
  Leader: Clark DuMontier, MD
 

Dr. DuMontier is geriatrician and research fellow in the Division of Aging, Brigham and Women’s Hospital (BWH) focused on integrating geriatrics into oncology, with a focus on functional assessment5. Multiple myeloma is a disease of aging, with two-thirds of patients diagnosed after age 65. Improving function in older adults with cancer is a high priority for patients, yet functional outcomes in multiple myeloma remain understudied. The objective of his proposal is to compare the feasibility of several measures of function that are well-established in aging research but underutilized in myeloma practice. He will recruit 50 transplant-ineligible patients age = 75 with newly-diagnosed multiple myeloma who plan to undergo induction chemotherapy and collect several patient-reported measures of function at these patients’ initial appointment and monthly thereafter for six months while undergoing induction chemotherapy. The study will determine which measures of physical function are valid and feasible to be completed by older patients in busy oncology clinics.  Dr. Dumontier’s primary research mentor is Dr. Jane Driver, MD, MPH, who co-directs the Older Adult Hematologic Malignancy Program at Dana-Farber. He will use the OAIC Functional Assessment and Biostatistical Design and Analysis Cores.

 
2. Project Title: REC-1: Impact of intensifying older adults’ antihypertensive medication regimens at hospital discharge on home blood pressure and functional recovery.
  Leader: Timothy S. Anderson, MD, MAS
 

Dr. Anderson is a general internist and Instructor in Medicine at Beth Israel Deaconess Medical Center (BIDMC). His prior research has analyzed large datasets to study clinical outcomes of older adults receiving changes to their chronic disease medications at hospital discharge4; this work is currently supported by a NIA GEMSSTAR Award. For the OIAC REC, he proposes to conduct a prospective cohort study of 90 community dwelling older adults hospitalized at BIDMC who experience elevated inpatient blood pressure (BP). He will assess the feasibility of recruiting these older adults at hospital discharge into a 3-month study during which they will complete home BP recordings and patient reported functional questionnaires. He will compare home BPs and functional recovery in patients who did and did not receive BP medication intensifications at hospital discharge. Completion of this proposal will allow Dr. Anderson to gain experience in prospective primary data collection. He will use the OAIC Functional Assessment and Biostatistical Design and Analysis Cores. His primary mentor is Dr. Edward Marcantonio, MD, SM, Associate Director of the OAIC REC.

 
3. Project Title: PES-3: Stress-driven acceleration of epigenetic age and inflammation in transgender adults.
  Leader: PI: Sari Reisner, ScD.
 

Results from this study will establish whether there is a link between exposure to gender-related psychosocial stress and epigentic age (DNA methylation score) and inflamm-aging (e.g., elevated CRP, IL-6 levels); and whether epigentic age and inflammation are related to levels of physical function. The study outcomes will inform a followup R01 to evaluate a combined behavioral and exercise intervention to reverse accelerated aging and inflamm-aging due to life course exposure to psychosocial stressors.

 
4. Project Title: PES-2: Senescence in development and progression of early pulmonary fibrosis in older adults.
  Leader: Jason Sanders, MD, PhD.
 

Interstitial lung abnormalities (ILA) may be part of a spectrum of interstitial lung disease that includes idiopathic pulmonary fibrosis (IPF) that increase with aging.  Senescent cell accumulation in the lungs of patients with ILA is the focus of this project and the investigator proposes to identify and test whether a candidate set of senescence biomarkers derived from preliminary proteomic data from senescent lung fibroblasts and peripheral blood are associated with ILA.  Given the significant decline in function arising in older adults with ILA, identifying a signature for senescent cell accumulation in such patients offers the opportunity to target these patients with senolytic agents, as has been done for the more extreme IPF condition . Furthermore the establishment of senescence signatures would enable patient stratification across an array of pulmonary lung disease states.

 
5. Project Title: PES-1: Senescent cells from organs of older donors are transferred during transplantation and impair the physical exercise capacity of recipients.
  Leader: PI: Abdala El Khal, PhD and Stefan Tullius, MD, PhD
 

The study will evaluate whether transplantation of younger organs into older recipients may delay aging and improve physical reserves. The study also hypothesizes that senolytics will improve organ quality, reduce the spread of senescent cells and improve physical function in older recipeints.

 
6. Project Title: REC-3: Contribution of Cellular Senescence to Delayed Wound Healing of Aging
  Leader: Daniel Roh, MD PhD
 


Dr. Roh is an Assistant Professor of Surgery at Boston University School of Medicine in the field of Plastic and Reconstructive Surgery whose research focus is to discover new translational therapies that can reduce the burden of wounds for the older adult6. His project will test the hypothesis that senescent cell accumulation in aged skin contributes to impaired wound healing, and that reduction of these cells can be a valuable tool to improve wound healing in aged individuals. Using aged mice, he will determine the contribution of senescent cell accumulation to the impaired wound healing of aging. He will evaluate topical senolytic therapy as a potential treatment and determine the effect of reducing senescent cell burden on the impaired wound healing of aging. Rejuvenating and strengthening aged skin with senolytics could be used as a preventative measure to avoid wound complications in patients at risk for acute wounds that develop into chronic wounds. In addition, this project proposes to establish potential biomarkers of senescence and wound healing status. Dr. Roh’s mentors include LaDora Thompson PT PhD, Vladimir Botchkarev MD PhD, and Laura Niedernhofer, MD PhD. His project will utilize the Biostatistical Design and Analysis and the Preclinical Discovery Cores. ?

 
7. Project Title: REC-4: Skeletal Muscle Perfusion and Energetics in Patients with Symptomatic Peripheral Artery Disease. Joint Boston OAIC-Harvard Catalyst C-MERIT Awardee.
  Leader: Sanjay Divakaran, MD
 

Dr. Divarkaran is an Instructor in Medicine in the Division of Cardiology, BWH. His research focuses on using perfusion and metabolic positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) to uncover changes in oxygen delivery and metabolism in older individuals with peripheral artery disease (PAD)7. Studying patients with PAD at rest and post-exercise with PET and MRS has the potential to help better phenotype patients with PAD and address critical gaps in knowledge regarding the pathophysiology of intermittent claudication. For the OAIC REC, he proposes to use PET, MRS, and omics technologies to study 10 older adults with PAD before and after endovascular revascularization procedures. He will perform novel pre- and post-exercise plasma biomarker discovery by measuring differential microRNA expression and targeted protein biomarkers. His mentors are Dr. Marcelo Di Carli, a world-expert in perfusion and metabolic PET imaging, and Dr. Mark Feinberg, Director of the Program of Cardiovascular RNA Biology at BWH. He will utilize the OAIC Functional Assessment, Preclinical Discovery, and Biostatistical Design and Analysis Cores.

 
DEVELOPMENT PROJECTS (3 Development Projects Listed)
1. Project Title: DP-1: A Real-Time Ecological Momentary Assessment Approach to Clinical Outcomes Assessment in Older Individuals
  Leader: Marcia Testa, MPH, PhD
  Core(s): Functional Assessment Core (FAC)
 

Continuous digital monitoring of physical functioning in the context of EMA of mood, pain, fatigue to optimally quantify beneficial impact of FPTs.

 
2. Project Title: DP-2: Measuring intracellular NAD in skeletal muscle and brain using 7T magnetic resonance spectroscopy
  Leader: Alex Lin, PhD and Ravi Jasuja, PhD
  Core(s):
 

The use of 7T MR spectroscopy to measure intracellular NAD in skeletal muscle and brain is novel and will be of value to ongoing and planned studies of NAD activators.

 
3. Project Title: DP-3: A novel statistical method to compare interventions initiated over time.
  Leader: Karo Pencina, PhD, Co-I: Thomas Travison, PhD.
  Core(s):
 

A novel statistical method to compare treatments initiated over time to enable epidemiological assessment of treatment disparities in older adults.

 
RESEARCH (9 Projects Listed)
1. Project Title: UNCOVERING MOLECULAR EFFECTORS OF MAMMALIAN AGING
  Leader(s): WAGERS, AMY JO
    HARVARD UNIVERSITY
    NIH DP1AG063419 / (2018-2023)
  Core(s):
  Aging is the single largest risk factor for most chronic degenerative diseases, including cardiovascular,musculoskeletal and neurodegenerative dysfunctions, and age-associated diseases now represent ...
 
2. Project Title: AGING-ASSOCIATED DYSREGULATION OF THE HYPOXIA PATHWAY LIMITS SKELETAL MUSCLE REGENERATION
  Leader(s): SINHA, INDRANIL
    BRIGHAM AND WOMEN'S HOSPITAL
    NIH K76AG059996 / (2018-2023)
  Core(s):
  Project Summary/Abstract This proposal describes a five-year training program and career development plan for Dr. IndranilSinha. Dr. Sinha is a prior trainee of a National Institute of Aging-sponsored Postdoctoral Individual NationalResearch Service Award (F32). He is a current awardee of a Research and Education Core Grant through theBoston Pepper Center and the National Institute of Aging. He ha...
 
3. Project Title: HEALTH OUTCOMES OF TAI CHI IN SUBSIDIZED SENIOR HOUSING
  Leader(s): LIPSITZ, LEWIS; WAYNE, PETER MICHAEL ;
    HEBREW REHABILITATION CENTER FOR AGED
    NIH R01AG025037 / (2006-2021)
  Core(s):
  DESCRIPTION (provided by applicant): Elderly people living in low-income housing facilities represent one of our nation's largest, most functionally impaired, economically disadvantaged, and understudied populations that account for a disproportionate share of Medicare spending. This revised competitive renewal application aims to improve the health and reduce the health care costs of this populat...
 
4. Project Title: REGULATION AND FUNCTION OF GROWTH DIFFERENTIATION FACTOR 11 DURING DEVELOPMENT AND AGING
  Leader(s): WAGERS, AMY JO
    HARVARD UNIVERSITY
    NIH R01AG048917 / (2016-2021)
  Core(s):
  DESCRIPTION (provided by applicant): Healthy skeletal muscle is essential to sustain normal physical function, and muscle undergoes multiple developmental and functional transitions during fetal, neonatal and adult life. In the latest stages of life, impaired muscle homeostasis and reduced muscle regenerative potential lead to progressive loss of muscle mass and strength. Importantly, r...
 
5. Project Title: EPIDEMIOLOGY AND RISK OF ANTIPSYCHOTIC USE IN HOSPITALIZED ELDERLY WITH DELIRIUM
  Leader(s): KIM, DAE HYUN
    BRIGHAM AND WOMEN'S HOSPITAL
    NIH R01AG056368 / (2018-2021)
  Core(s):
  PROJECT SUMMARY/ABSTRACTEach year 2 million older adults receive antipsychotic medications (APMs) in the hospital, mainly for delirium.Although the harms of APMs are well documented and their use has declined in older adults with dementia, thescope and risk of off-label APM exposure in hospitalized older adults remain largely unknown. The objective ofthis application is to determine the prescribin...
 
6. Project Title: INVESTIGATING GDF11 AND MSTN AS CANDIDATE CIRCULATING GERONIC FACTORS
  Leader(s): WAGERS, AMY JO
    HARVARD UNIVERSITY
    NIH R01AG057428 / (2017-2021)
  Core(s):
  Project SummaryStudies using heterochronic parabiosis, a surgical intervention that establishes bi-directional cross-circulationbetween young and old animals, strongly indicate the existence of blood-borne factors that regulate theregeneration and homeostasis of skeletal muscle, and other tissues, in an age-dependent manner. Work frommy lab and others implicate the circulating proteins Growth Diff...
 
7. Project Title: PROSPECTIVE MONITORING OF NEWLY APPROVED CARDIOVASCULAR DRUGS IN OLDER ADULTS WITH FRAILTY
  Leader(s): KIM, DAE HYUN
    BRIGHAM AND WOMEN'S HOSPITAL
    NIH R01AG062713 / (2019-2023)
  Core(s):
  PROJECT SUMMARY/ABSTRACTCardiovascular disease (CVD) affects 70% of older adults and remains the leading cause of morbidity and mor-tality in the United States. Several new drugs have recently been approved for CVD, but not enough is knownabout their utilization, benefits and risks in frail older patients. Since conducting a clinical trial in frail older adultscan be costly and impractical, there ...
 
8. Project Title: ASBMR THREE YEAR SYMPOSIA
  Leader(s): CAULEY, JANE ANN; CAWTHON, PEGGY MANNEN ; EDWARDS, CLAIRE ; KIEL, DOUGLAS P. ;
    AMERICAN SOCIETY FOR BONE & MINERAL RES
    NIH R13AR074882 / (2019-2022)
  Core(s):
  The American Society for Bone and Mineral Research (ASBMR), the largest professional, scientific andmedical society established to bring together clinical and laboratory-based scientists who are involved in thestudy of bone, mineral and musculoskeletal science, has had a successful history of conducting annual topicalmeetings funded by single year NIH R13 grants since 2002. In 2015, ASBMR received...
 
9. Project Title: RESTRICTED MEAN SURVIVAL TIME TO INTERPRET CLINICAL TRIALS FOR TREATMENT DECISION-MAKING IN OLDER ADULTS
  Leader(s): KIM, DAE HYUN
    HEBREW REHABILITATION CENTER FOR AGED
    NIH R21AG060227 / (2019-2021)
  Core(s):
  PROJECT SUMMARY/ABSTRACTPatient-centered care of older adults with multimorbidity involves shared decision-making based on accuratecommunication of evidence. In clinical trials, treatment effect is conventionally summarized in terms of relativerisk reduction using hazard ratios and absolute risk reduction. Despite widespread use, these conventionalmeasures based on probabilities are not well under...
 
PUBLICATIONS
2021
  1. Objective performance tests of cognition and physical function as part of a virtual geriatric assessment.
    Bahl NE, Magnavita ES, Hshieh T, Testa M, Kim D, Manor B, Driver JA, Abel GA, DuMontier C
    J Geriatr Oncol, 2021 Mar 29
    pii: S1879-4068(21)00083-7. https://doi.org/10.1016/j.jgo.2021.03.013 | PMID: 33795206
    Citations: | AltScore: NA
  2. Systemic and cerebral circulatory adjustment within the first 60?s after active standing: An integrative physiological view.
    Harms MPM, Finucane C, P?rez-Denia L, Juraschek SP, van Wijnen VK, Lipsitz LA, van Lieshout JJ, Wieling W
    Auton Neurosci, 2021 Mar, 231: 102756
    https://doi.org/10.1016/j.autneu.2020.102756 | PMID: 33385733 | PMCID: PMC8103784
    Citations: | AltScore: 2.95
  3. Total carotenoid intake is associated with reduced loss of grip strength and gait speed over time in adults: The Framingham Offspring Study.
    Sahni S, Dufour AB, Fielding RA, Newman AB, Kiel DP, Hannan MT, Jacques PF
    Am J Clin Nutr, 2021 Feb 2, 113(2): 437-445
    https://doi.org/10.1093/ajcn/nqaa288 | PMID: 33181830 | PMCID: PMC7851823
    Citations: 1 | AltScore: 18.35
 
2020
  1. Markers of Iron Flux during Testosterone-Mediated Erythropoiesis in Older Men with Unexplained or Iron-Deficiency Anemia.
    Artz AS, Stephens-Shields AJ, Bhasin S, Ellenberg SS, Cohen HJ, Snyder PJ
    J Clin Endocrinol Metab, 2020 Nov 1, 105(11):
    pii: dgaa521. https://doi.org/10.1210/clinem/dgaa521 | PMID: 32785689 | PMCID: PMC7500468
    Citations: 1 | AltScore: NA
  2. Adult-Onset Myopathy with Constitutive Activation of Akt following the Loss of hnRNP-U.
    Bagchi D, Mason BD, Baldino K, Li B, Lee EJ, Zhang Y, Chu LK, El Raheb S, Sinha I, Neppl RL
    iScience, 2020 Jul 24, 23(7): 101319
    https://doi.org/10.1016/j.isci.2020.101319 | PMID: 32659719 | PMCID: PMC7358745
    Citations: 1 | AltScore: 1.25
  3. Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
    Balachandran A, Gundermann DM, Walkup MP, King AC, Ambrosius WT, Kritchevsky SB, Pahor M, Newman AB, Manini TM
    Med Sci Sports Exerc, 2020 Apr, 52(4): 859-867
    https://doi.org/10.1249/MSS.0000000000002195 | PMID: 31688650 | PMCID: PMC7123515
    Citations: | AltScore: 5
  4. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.
    Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P, STRIDE Trial Investigators.
    N Engl J Med, 2020 Jul 9, 383(2): 129-140
    https://doi.org/10.1056/NEJMoa2002183 | PMID: 32640131 | PMCID: PMC7421468
    Citations: 8 | AltScore: 274.196
  5. Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.
    Cort?s YI, Barinas-Mitchell E, Suder Egnot N, Bhasin S, Jasuja R, Santoro N, Thurston RC
    J Clin Endocrinol Metab, 2020 Apr 1, 105(4):
    pii: dgz327. https://doi.org/10.1210/clinem/dgz327 | PMID: 31900485 | PMCID: PMC7077951
    Citations: 1 | AltScore: 257.1
  6. Loss of ARNT in skeletal muscle limits muscle regeneration in aging.
    Endo Y, Baldino K, Li B, Zhang Y, Sakthivel D, MacArthur M, Panayi AC, Kip P, Spencer DJ, Jasuja R, Bagchi D, Bhasin S, Nuutila K, Neppl RL, Wagers AJ, Sinha I
    FASEB J, 2020 Oct 8, 34(12): 16086-16104
    https://doi.org/10.1096/fj.202000761RR | PMID: 33064329 | PMCID: PMC7756517
    Citations: 1 | AltScore: 8.4
  7. The Stair Climb Power Test as an Efficacy Outcome in Randomized Trials of Function Promoting Therapies in Older Men.
    Gagliano-Juc? T, Li Z, Pencina KM, Traustad?ttir T, Travison TG, Woodhouse L, Basaria S, Tsitouras PD, Harman SM, Bhasin S, Storer TW
    J Gerontol A Biol Sci Med Sci, 2020 May 22, 75(6): 1167-1175
    https://doi.org/10.1093/gerona/glz167 | PMID: 31282538 | PMCID: PMC7984416
    Citations: | AltScore: NA
  8. Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials.
    Gagliano-Juc? T, Pencina KM, Guo W, Li Z, Huang G, Basaria S, Bhasin S
    Andrology, 2020 Jun 2, 8(5): 1324-1331
    https://doi.org/10.1111/andr.12834 | PMID: 32485095 | PMCID: PMC7484244
    Citations: | AltScore: 2.5
  9. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
    Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB, Lifestyle Interventions and Independence for Elders Study Group.
    J Am Geriatr Soc, 2020 Mar, 68(3): 619-624
    https://doi.org/10.1111/jgs.16274 | PMID: 31867713 | PMCID: PMC8061638
    Citations: | AltScore: 22.45
  10. Estimation of ascertainment bias and its effect on power in clinical trials with time-to-event outcomes.
    Greene EJ, Peduzzi P, Dziura J, Meng C, Miller ME, Travison TG, Esserman D
    Stat Med, 2020 Dec 14, 40(5): 1306-1320
    https://doi.org/10.1002/sim.8842 | PMID: 33316841
    Citations: 1 | AltScore: NA
  11. Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: a pilot study.
    Grosicki GJ, Riemann BL, Flatt AA, Valentino T, Lustgarten MS
    Sleep Med, 2020 Sep, 73: 76-81
    https://doi.org/10.1016/j.sleep.2020.04.013 | PMID: 32795890 | PMCID: PMC7487045
    Citations: 3 | AltScore: 16.75
  12. Dietary Sodium Intake and Sodium Density in the United States: Estimates From NHANES 2005-2006 and 2015-2016.
    Hu JR, Sahni S, Mukamal KJ, Millar CL, Wu Y, Appel LJ, Juraschek SP
    Am J Hypertens, 2020 Sep 10, 33(9): 825-830
    https://doi.org/10.1093/ajh/hpaa104 | PMID: 32619231 | PMCID: PMC7481988
    Citations: 1 | AltScore: 5.05
  13. Evaluation of Clinically Meaningful Changes in Measures of Frailty.
    Jang IY, Jung HW, Lee HY, Park H, Lee E, Kim DH
    J Gerontol A Biol Sci Med Sci, 2020 May 22, 75(6): 1143-1147
    https://doi.org/10.1093/gerona/glaa003 | PMID: 32145016 | PMCID: PMC7243580
    Citations: 3 | AltScore: 6.7
  14. Diminished Locomotor Control Is Associated With Reduced Neurovascular Coupling in Older Adults.
    Jor'dan AJ, Manor B, Iloputaife I, Habtemariam DA, Bean JF, Sorond FA, Lipsitz LA
    J Gerontol A Biol Sci Med Sci, 2020 Jul 13, 75(8): 1516-1522
    https://doi.org/10.1093/gerona/glz006 | PMID: 30629129 | PMCID: PMC7357586
    Citations: 2 | AltScore: 3
  15. Cognition, Frailty, and Functional Outcomes of Transcatheter Aortic Valve Replacement.
    Kapadia M, Shi SM, Afilalo J, Popma JJ, Laham RJ, Guibone K, Kim DH
    Am J Med, 2020 Oct, 133(10): 1219-1222
    https://doi.org/10.1016/j.amjmed.2020.01.041 | PMID: 32199811 | PMCID: PMC7501150
    Citations: | AltScore: 9.05
  16. The Impact of Frailty on Long-Term Patient-Oriented Outcomes after Emergency General Surgery: A Retrospective Cohort Study.
    Lee KC, Streid J, Sturgeon D, Lipsitz S, Weissman JS, Rosenthal RA, Kim DH, Mitchell SL, Cooper Z
    J Am Geriatr Soc, 2020 Feb 11, 68(5): 1037-1043
    https://doi.org/10.1111/jgs.16334 | PMID: 32043562 | PMCID: PMC7234900
    Citations: 5 | AltScore: 33.95
  17. Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
    Pahor M, Guralnik JM, Anton SD, Ambrosius WT, Blair SN, Church TS, Espeland MA, Fielding RA, Gill TM, Glynn NW, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Williamson JD
    J Am Geriatr Soc, 2020 Apr, 68(4): 872-881
    https://doi.org/10.1111/jgs.16365 | PMID: 32105353 | PMCID: PMC7187344
    Citations: 5 | AltScore: 13.35
  18. Multicomponent Intervention and Long-Term Disability in Older Adults: A Nonrandomized Prospective Study.
    Park CM, Oh G, Lee H, Jung HW, Lee E, Jang IY, Kim DH
    J Am Geriatr Soc, 2020 Nov 5, 69(3): 669-677
    https://doi.org/10.1111/jgs.16926 | PMID: 33155305 | PMCID: PMC7969416
    Citations: | AltScore: NA
  19. Sarcopenia is associated with severe erectile dysfunction in older adults: a population-based cohort study.
    Park H, Jang IY, Han M, Lee H, Jung HW, Lee E, Kim DH
    Korean J Intern Med, 2020 Apr 21, 35(5): 1245-1253
    https://doi.org/10.3904/kjim.2019.148 | PMID: 32306710 | PMCID: PMC7487308
    Citations: | AltScore: 7.75
  20. Perceived social isolation, social disconnectedness and falls: the mediating role of depression.
    Quach LT, Burr JA
    Aging Ment Health, 2020 Mar 5, 25(6): 1029-1034
    https://doi.org/10.1080/13607863.2020.1732294 | PMID: 32131617 | PMCID: PMC7483756
    Citations: 2 | AltScore: 11
  21. Patterns of multi-domain cognitive aging in participants of the Long Life Family Study.
    Sebastiani P, Andersen SL, Sweigart B, Du M, Cosentino S, Thyagarajan B, Christensen K, Schupf N, Perls TT
    Geroscience, 2020 Jun 8, 42(5): 1335-1350
    https://doi.org/10.1007/s11357-020-00202-3 | PMID: 32514870 | PMCID: PMC7525612
    Citations: 1 | AltScore: 1.75
  22. Risk Factors, Presentation, and Course of Coronavirus Disease 2019 in a Large, Academic Long-Term Care Facility.
    Shi SM, Bakaev I, Chen H, Travison TG, Berry SD
    J Am Med Dir Assoc, 2020 Oct, 21(10): 1378-1383.e1
    https://doi.org/10.1016/j.jamda.2020.08.027 | PMID: 32981664 | PMCID: PMC7447263
    Citations: 21 | AltScore: 62.5
  23. The functional implications and modifiability of resting-state brain network complexity in older adults.
    Zhou J, Lo OY, Halko MA, Harrison R, Lipsitz LA, Manor B
    Neurosci Lett, 2020 Feb 16, 720: 134775
    https://doi.org/10.1016/j.neulet.2020.134775 | PMID: 31972253 | PMCID: PMC7069223
    Citations: 1 | AltScore: 1.35


EXTERNAL ADVISORY BOARD MEMBERS

Laura Niedernhofer, MD, PhD
University of Minnesota Medical School
Serving since 2016 (5 years)

Marco Pahor, MD
University of Florida Institute on Aging
Serving since 2016 (5 years)

Steven Kritchevsky, PhD
Wake Forest
Serving since 2016 (5 years)

Thomas Gill, MD
Yale University
Serving since 2016 (5 years)


RECOGNITION AND AWARDS (2020-2021)

Recognition and Awards not specified.

MINORITY RESEARCH

General Brief Description of Minority Activities:
Not defined.


No minority trainee information specified.

No minority grant information specified.