Claude D. Pepper Older Americans Independence Center

  Principal Investigator    Marco Pahor, M.D.  352-294-5800
  Program Administrator    Lauren Crump, MPH  352-294-5800

The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons’ physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: “mobility and prevention of disability.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC’s general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: Leadership and Administrative Core; Research Education Core; Pilot/Exploratory Studies Core; Clinical Research Core; Metabolism and Translational Science Core; Biostatistics Core; and Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.

Research hypotheses:
  • Multiple biological, co-morbid, psychosocial, cognitive, and behavioral factors contribute to agerelated physical function decline, loss of mobility, and progression to disability.
  • Interventions that target individual or multiple biological, co-morbid, psychosocial, cognitive, and behavioral risk factors of physical function decline avert the loss of mobility and prevent disability.
Research objectives:
  • Assess, by taking advantage of a bidirectional translation between basic and clinical research, the multiple factors that contribute to physical function decline, loss of mobility, and progression to disability.
  • Develop and test pharmacological, nutritional, and behavioral interventions for preventing decline in physical function, loss of mobility, and progression to disability.
Educational objectives:
  • Educate and train new investigators in research on aging and disability in older adults.
  • Develop leadership qualities and roles in Junior Scholars supported by the OAIC.
  • Develop skills for translating findings between basic and clinical research.
Operational objectives:
  • To provide outstanding investigators and state-of-the-art resources, environment, and services to support the above-mentioned research and educational objectives.

  Biostatistical Design and Analysis Core (BDAC)
Leader 1:    Samuel Wu, PhD
No Description

Clinical Research Core (CRC)
Leader 1:    Stephen Anton, PhD
No Description

Data and Analysis Core (DAC)
Leader 1:    Todd Manini, PhD
Leader 2:    Sanjay Ranka, PhD
No Description

Leadership and Administrative Core (LAC)
Leader 1:    Marco Pahor, MD
The Leadership and Administrative Core (LAC) is responsible for strategic planning, organization, administrative operations, and evaluation of the Older Americans Independence Center (OAIC) research and training program. A special effort is devoted to ensure the cohesion of the Center and maintain an interdisciplinary and translational research focus on the common research theme, which is “mobility and prevention of disability.” The Core Leader and three committees achieve the key LAC tasks. The Executive Committee, which is composed of the OAIC core leaders, administers, governs, provides scientific guidance, and sets productivity benchmarks for the OAIC. The External Advisory Board, which is composed of experts external to the institution, reviews all OAIC activities and provides overall scientific guidance to the OAIC. The Independent Review Panel, which is composed of ad hoc experts (at least one third external to the institution), reviews proposed support for development projects, and pilot/exploratory studies. Taken together, the LAC provides support for planning, organizational, evaluation, and administrative activities relating to the other cores and to the OAIC as a whole. The LAC monitors, stimulates, sustains, evaluates, and reports progress toward the overall goals of the OAIC.

Metabolism and Translational Science
Leader 1:    Christiaan Leeuwenburgh, PhD
No Description

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Yenisel Cruz-Almeida, Ph.D.
Leader 2:    Rui Xiao, Ph.D
The Pilot/Exploratory Studies Core serves to develop key information needed to select and design future, original and independently funded studies that can advance our insight into sarcopenia and prevention of disability in older Americans. Specifically, the core fosters the Pilot and Exploratory studies by ensuring the availability of optimal infrastructure, environment, funding, expertise, and instrumentation. Pilot and Exploratory studies foster Junior Scholars in their efforts to develop research careers in aging by providing opportunities for meaningful participation in well-designed research studies and by collecting the needed preliminary data for independent research applications. Furthermore, these studies will allow investigators already accomplished in aging research to gather data that will extend and broaden their focus of research. Finally, these studies will also be a vehicle to encourage and facilitate experienced investigators traditionally working in other research fields to focus on aging.

Research Education Component (REC)
Leader 1:    Christiaan Leeuwenburgh, PhD
Leader 2:    Kenneth Cusi, MD
The REC promotes the development of independent investigators in interdisciplinary research on aging relevant to the independence of older Americans. One of our major goals is to identify the most promising Junior Scholars with research relevant to the OAIC theme at UF & VA and to provide them with mentorship, training activities, access to OAIC Core resources and funding and enable them to become independent investigators in interdisciplinary aging research. Furthermore, this core emphasizes the development of leadership, and research skills for translating basic findings into clinical research and clinical findings into basic research. The REC supports the research training of OAIC Junior Scholars that span the spectrum from beginning trainees who are not yet funded to advanced trainees who already have competed successfully for career development grants that provide substantial salary support.

  B. RESEARCH (3 Projects Listed)
  Leader(s): KIM, JAE-SUNG
    NIH R01DK079879 / (2007-2020)
  DESCRIPTION (provided by applicant): Mitochondrial dysfunction is the major mechanism precipitating I/R injury which commonly occurs during liver surgery, trauma, hemorrhagic shock and liver transplantation. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that induces longevity, stress resistance and tumor suppression. The role of SIRT1 in ischemia/reperfusion-mediated liver injury is unknown. The goal of this study is to investigate the role of SIRT1 in I/Rinjury to liver and to develop therapeutic strategies to improve liver function after I/R. Our principal hypothesis is that calpain-dependent SIRT1 loss causes a sequential chain of defective mitophagy, mitochondrial permeability transition (MPT) onset and hepatocyte death after I/R. Accordingly, we propose that restoration or enhancement of hepatic SIRT1 will promote mitophagy and consequently ameliorate mitochondrial failure and liver dysfunction after reperfusion. To test our hypothesis, we will use hepatocytes isolated from SIRT1 wild type (WT) and knockout (KO) mice for characterization of cellular mechanisms causing SIRT1 depletion, defective mitophagy, and onset of the MPT and cell death after I/R. In addition, we will use anesthetized WT and KO SIRT1 mice to confirm and extend our in vitro findings to an in vivo model of hepatic I/R. Finally, we will extend and translate our findings from mice into human liver biopsies. These studies provide critical mechanistic insights into lethal I/R injury to the lver, and will establish novel therapeutic approaches for improving I/R-mediated liver failure.
  Leader(s): EFRON, PHILIP A
    NIH R01GM113945 / (2015-2020)
  DESCRIPTION (provided by applicant): People of advanced age (greater than 55 years old) have significantly increased morbidity and mortality after trauma. Since the elderly population is expanding, research into this disease process is increasingly relevant, especially with the escalating economic and health care burdens on our society. Despite decades of promising preclinical and clinical investigations in trauma, our understanding of this entity and why its effects are exacerbated in the elderly remains incomplete, with few therapies demonstrating success in any patient population. Recently, several aspects of innate immunity have been determined to be of vital importance to the young adult immune response, and this response is suboptimal in the aged after severe injury and subsequent infections. Specifically, neutrophils are replaced after inflammation through a process known as 'emergency myelopoiesis.' This occurs after severe injury when bone marrow granulocyte stores are rapidly released, and increased stem cell proliferation and differentiation along myeloid pathways results. Proper differentiation of myeloid cells from stem cells is dependent on activation of nuclear factor kappaB (NFB), a protein complex that partially controls DNA transcription after stressful stimuli. Anappropriate emergency myelopoietic response to inflammation is essential to host survival but appears to be inadequate in the elderly as compared to younger patients. Specifically, we hypothesize that the myelodysplasia associated with aging modifies the emergency myelopoietic response to traumatic injury, resulting in inappropriate differentiation and maturation of myeloid cells, leaving the host susceptible to subsequent infection. We further propose that this failure of emergency myelopoiesis is due to age-associated, chronic activation of NFB-dependent inflammatory pathways, and a failure of hematopoietic stems cells (LSK populations) after trauma to create functional myeloid populations in a NFB-dependent manner. Using a novel murine polytrauma (PT) model of murine hemorrhagic shock and injury that better recapitulates the human condition, we will: (1) determine if certain hematopoietic stem cells (HSCs), specifically short term-HSCs (ST-HSCs), fail to properly expand and differentiate along myeloid pathways in the elderly response to trauma, and, if the resultant dysfunctional neutrophil population seen in the elderly after trauma results from these suboptimal ST-HSCs; (2) determine if the defects in aged ST-HSC function after severe injury, as compared to their juvenile counterparts, are caused by a chronic low-grade NFB-dependent inflammatory state and a subsequent failure to appropriately activate NFB-dependent pathways after trauma; and, (3) determine if the HSC senescence associated with elderly humans after severe trauma is also due to a failure to appropriately activate NFB-dependent pathways in bone marrow HSCs. This work proposes that increased susceptibility to infection after trauma in aging is due, at least in part, to defects in myelopoiesis that lead to genotypically, phenotypically and functionally deranged PMNs that fail to control infection. The third specific aim will translate our 'bench side' animal work to humans and this innovative approach could identify areas for intervention in cell types that are still exhibit plasticity.
    NIH R21AG064282 / (2019-2021)
  ABSTRACTMore than 80% of older adults have hypertension, with higher prevalence of high systolic blood pressure (SBP)putting them at high risk for cardiovascular (CV) disease and death. Because drug therapy that lowers SBP isassociated with side effects such as hypotension, syncope, and kidney dysfunction, there is a great need foreffective lifestyle SBP-lowering interventions for the older population that can replace drug therapy. Whileaerobic exercise is a recommended lifestyle intervention for controlling SBP and preventing CV diseasenaturally, in older adults it has been shown to be less effective in vascular-tissue remodeling because ofarterial stiffness, resulting in less efficient SBP control. Reduced bioavailability of nicotinamide adeninedinucleotide (NAD+), a cofactor for the deacetylase sirtuin1 (SIRT1), may contribute to age-related vasculardysfunction via oxidative stress and reduced nitric oxide (NO). Exercise-induced overexpression of NAD+-dependent SIRT1 improves the bioavailability of NO. Preclinical evidence suggests that poor vascular-functionimprovement in response to exercise in older mice is caused by insufficient NAD+ levels to stimulate SIRT1activity. Importantly, replenishment of NAD+ levels induced vascular remodeling, improved vascularfunction, and reduced SBP in mice. An objective of this study, therefore, is to test a combination of aerobicexercise and nicotinamide riboside, a compound that replenishes NAD+ levels, to optimize exercise's SBP-lowering effect in hypertensive older adults. Initial human clinical trials demonstrated that nicotinamide ribosidesupplementation (1,000 mg/day) was safe and showed a higher potential to reduce SBP and arterial stiffnessin participants with elevated SBP. As we have preclinical evidence that combining NAD+ replenishment withexercise is an ideal strategy for improving vascular function, our central hypothesis is that the intervention ofaerobic-exercise training combined with nicotinamide riboside supplementation will reduce SBP inhypertensive older adults more effectively than will exercise alone. We will enroll 45 participants 65 years andolder into either: (1) 1,000 mg/day of nicotinamide riboside plus 3 days/week of supervised, center-basedwalking exercise, or (2) the same exercise program combined with placebo, or (3) 1,000 mg/day ofnicotinamide riboside alone. All participants will undergo daytime continuous SBP and arterial-stiffnessmeasurements by pulse-wave velocity at baseline and at 6 weeks. Elevated SBP will then be determined asdaytime average above 130 mmHg, measured by the 24-hour blood-pressure device. To our knowledge, thisstudy will be the first attempt to enhance exercise therapy with nicotinamide riboside in hypertensive olderadults. We believe that nicotinamide riboside is ?the missing piece of the puzzle? in improving vascularremodeling and SBP management in older adults. Preliminary evidence from this pilot study may support a full-scale Phase III clinical trial in hypertensive older adults. The ultimate goal of this line of research is to findadjuvant strategies to improve the exercise's SBP-lowering effects in older adults.
  C. PILOT/EXPLORATORY PROJECTS (0 Pilot Projects Listed)
  No pilot/exploratory projects.
  D. DEVELOPMENT PROJECTS (0 Development Projects Listed)
  No development projects.
REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications

None specified.

  1. Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
    Balachandran A, Gundermann DM, Walkup MP, King AC, Ambrosius WT, Kritchevsky SB, Pahor M, Newman AB, Manini TM
    Med Sci Sports Exerc, 2020 Apr, 52(4): 859-867 | PMID: 31688650 | PMCID: PMC7123515
    Citations: | AltScore: 4.85
  2. Pain, aging, and the brain: new pieces to a complex puzzle.
    Cruz-Almeida Y, Cole J
    Pain, 2020 Mar, 161(3): 461-463 | PMID: 31764392 | PMCID: PMC7134332
    Citations: | AltScore: 5.75
  3. Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.
    Febo M, Rani A, Yegla B, Barter J, Kumar A, Wolff CA, Esser K, Foster TC
    Front Aging Neurosci, 2020, 12: 34 | PMID: 32153384 | PMCID: PMC7044155
    Citations: | AltScore: 4
  4. Determinants of Adherence in Time-Restricted Feeding in Older Adults: Lessons from a Pilot Study.
    Lee SA, Sypniewski C, Bensadon BA, McLaren C, Donahoo WT, Sibille KT, Anton S
    Nutrients, 2020 Mar 24, 12(3):
    pii: E874. | PMID: 32213965 | PMCID: PMC7146127
    Citations: | AltScore: 0.75
  5. Delayed interhospital transfer of critically ill patients with surgical sepsis.
    Loftus TJ, Wu Q, Wang Z, Lysak N, Moore FA, Bihorac A, Efron PA, Mohr AM, Brakenridge SC
    J Trauma Acute Care Surg, 2020 Jan, 88(1): 169-175 | PMID: 31856021 | PMCID: PMC6927529
    Citations: | AltScore: 16.95
  6. Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
    Mankowski RT, Anton SD, Ghita GL, Brumback B, Cox MC, Mohr AM, Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA
    J Am Geriatr Soc, 2020 Apr 15 | PMID: 32294254
    Citations: 1 | AltScore: 3.6
  7. Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
    Pahor M, Guralnik JM, Anton SD, Ambrosius WT, Blair SN, Church TS, Espeland MA, Fielding RA, Gill TM, Glynn NW, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Williamson JD
    J Am Geriatr Soc, 2020 Apr, 68(4): 872-881 | PMID: 32105353 | PMCID: PMC7187344
    Citations: | AltScore: 10.4
  8. Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
    Park HJ, Kim MJ, Han C, White K, Ding D, Boyd K, Salvi R, Someya S
    Exp Gerontol, 2020 May, 133: 110872 | PMID: 32044382 | PMCID: PMC7062562
    Citations: | AltScore: NA
  9. Reliability and Validity of the Short-Form 12 Item Version 2 (SF-12v2) Health-Related Quality of Life Survey and Disutilities Associated with Relevant Conditions in the U.S. Older Adult Population.
    Shah CH, Brown JD
    J Clin Med, 2020 Feb 29, 9(3):
    pii: E661. | PMID: 32121371 | PMCID: PMC7141358
    Citations: | AltScore: 1.85
  10. Neuropathic-Like Pain Symptoms in a Community-Dwelling Sample with or at Risk for Knee Osteoarthritis.
    Terry EL, Booker SQ, Cardoso JS, Sibille KT, Bartley EJ, Glover TL, Vaughn IA, Thompson KA, Bulls HW, Addison AS, Staud R, Hughes LB, Edberg JC, Redden DT, Bradley LA, Goodin BR, Fillingim RB
    Pain Med, 2020 Jan 1, 21(1): 125-137 | PMID: 31150093 | PMCID: PMC6953341
    Citations: | AltScore: 3.85
  1. The Relationship Between ?-Endorphin and Experimental Pain Sensitivity in Older Adults With Knee Osteoarthritis.
    Ahn H, La JH, Chung JM, Miao H, Zhong C, Kim M, An K, Lyon D, Choi E, Fillingim RB
    Biol Res Nurs, 2019 Jul, 21(4): 400-406 | PMID: 31146541 | PMCID: PMC6794665
    Citations: | AltScore: NA
  2. The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.
    Anton SD, Lee SA, Donahoo WT, McLaren C, Manini T, Leeuwenburgh C, Pahor M
    Nutrients, 2019 Jun 30, 11(7):
    pii: E1500. | PMID: 31262054 | PMCID: PMC6682944
    Citations: 9 | AltScore: 8.95
  3. Multimodal Intervention to Improve Functional Status in Hypertensive Older Adults: A Pilot Randomized Controlled Trial.
    Baptista LC, Jaeger BC, Anton SD, Bavry AA, Handberg EM, Gardner AK, Harper SA, Roberts LM, Sandesara B, Carter CS, Buford TW
    J Clin Med, 2019 Feb 6, 8(2):
    pii: E196. | PMID: 30736317 | PMCID: PMC6406861
    Citations: 2 | AltScore: 1.75
  4. Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis.
    Barter J, Kumar A, Stortz JA, Hollen M, Nacionales D, Efron PA, Moldawer LL, Foster TC
    Mol Neurobiol, 2019 Dec, 56(12): 8557-8572 | PMID: 31278440 | PMCID: PMC6834928
    Citations: 1 | AltScore: 1.25
  5. Race/Ethnicity Moderates the Association Between Psychosocial Resilience and Movement-Evoked Pain in Knee Osteoarthritis.
    Bartley EJ, Hossain NI, Gravlee CC, Sibille KT, Terry EL, Vaughn IA, Cardoso JS, Booker SQ, Glover TL, Goodin BR, Sotolongo A, Thompson KA, Bulls HW, Staud R, Edberg JC, Bradley LA, Fillingim RB
    ACR Open Rheumatol, 2019 Mar, 1(1): 16-25 | PMID: 31777776 | PMCID: PMC6858004
    Citations: 1 | AltScore: NA
  6. Multisystem Resiliency as a Predictor of Physical and Psychological Functioning in Older Adults With Chronic Low Back Pain.
    Bartley EJ, Palit S, Fillingim RB, Robinson ME
    Front Psychol, 2019, 10: 1932 | PMID: 31507491 | PMCID: PMC6714590
    Citations: | AltScore: NA
  7. Computer and Videogame Interventions for Older Adults' Cognitive and Everyday Functioning.
    Belchior P, Yam A, Thomas KR, Bavelier D, Ball KK, Mann WC, Marsiske M
    Games Health J, 2019 Apr, 8(2): 129-143 | PMID: 30273002 | PMCID: PMC6482895
    Citations: | AltScore: 1.5
  8. Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics.
    Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE
    Sci Rep, 2019 Oct 29, 9(1): 15547 | PMID: 31664123 | PMCID: PMC6820860
    Citations: 1 | AltScore: 7.8
  9. MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery.
    Bihorac A, Ozrazgat-Baslanti T, Ebadi A, Motaei A, Madkour M, Pardalos PM, Lipori G, Hogan WR, Efron PA, Moore F, Moldawer LL, Wang DZ, Hobson CE, Rashidi P, Li X, Momcilovic P
    Ann Surg, 2019 Apr, 269(4): 652-662 | PMID: 29489489 | PMCID: PMC6110979
    Citations: 13 | AltScore: 27.9
  10. Movement-evoked pain, physical function, and perceived stress: An observational study of ethnic/racial differences in aging non-Hispanic Blacks and non-Hispanic Whites with knee osteoarthritis.
    Booker S, Cardoso J, Cruz-Almeida Y, Sibille KT, Terry EL, Powell-Roach KL, Riley JL 3rd, Goodin BR, Bartley EJ, Addison AS, Staud R, Redden D, Bradley L, Fillingim RB
    Exp Gerontol, 2019 Sep, 124: 110622 | PMID: 31154005 | PMCID: PMC6660381
    Citations: | AltScore: 1
  11. Exercise is Medicine as a Vital Sign: Challenges and Opportunities.
    Bowen PG, Mankowski RT, Harper SA, Buford TW
    Transl J Am Coll Sports Med, 2019 Jan 1, 4(1): 1-7
    PMID: 30828640 | PMCID: PMC6392189
    Citations: 1 | AltScore: 20.55
  12. Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.
    Brakenridge SC, Efron PA, Cox MC, Stortz JA, Hawkins RB, Ghita G, Gardner A, Mohr AM, Anton SD, Moldawer LL, Moore FA
    Ann Surg, 2019 Sep, 270(3): 502-510 | PMID: 31356275 | PMCID: PMC6942687
    Citations: 3 | AltScore: 8.8
  13. Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.
    Brakenridge SC, Moore FA, Mercier NR, Cox M, Wu Q, Moldawer LL, Mohr AM, Efron PA, Smith RS
    J Am Coll Surg, 2019 Jul, 229(1): 58-67.e1 | PMID: 30991107 | PMCID: PMC6599553
    Citations: 2 | AltScore: 6.1
  14. Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use.
    Brown JD, Winterstein AG
    J Clin Med, 2019 Jul 8, 8(7):
    pii: E989. | PMID: 31288397 | PMCID: PMC6678684
    Citations: 3 | AltScore: 36
  15. The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations.
    Butera KA, Roff SR, Buford TW, Cruz-Almeida Y
    J Pain Res, 2019, 12: 1115-1125 | PMID: 30992680 | PMCID: PMC6445225
    Citations: 1 | AltScore: NA
  16. A Novel Mouse Model of <i>MYO7A</i> USH1B Reveals Auditory and Visual System Haploinsufficiencies.
    Calabro KR, Boye SL, Choudhury S, Fajardo D, Peterson JJ, Li W, Crosson SM, Kim MJ, Ding D, Salvi R, Someya S, Boye SE
    Front Neurosci, 2019, 13: 1255 | PMID: 31824252 | PMCID: PMC6883748
    Citations: | AltScore: NA
  17. The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results.
    Cauley JA, Manini TM, Lovato L, Talton J, Anton SD, Domanchuk K, Kennedy K, Stowe CL, Walkup M, Fielding RA, Kritchevsky SB, McDermott MM, Newman AB, Ambrosius WT, Pahor M, ENRGISE Investigators.
    J Gerontol A Biol Sci Med Sci, 2019 Jul 12, 74(8): 1296-1302 | PMID: 30202946 | PMCID: PMC6625594
    Citations: 3 | AltScore: 1.5
  18. Interpreting Prefrontal Recruitment During Walking After Stroke: Influence of Individual Differences in Mobility and Cognitive Function.
    Chatterjee SA, Fox EJ, Daly JJ, Rose DK, Wu SS, Christou EA, Hawkins KA, Otzel DM, Butera KA, Skinner JW, Clark DJ
    Front Hum Neurosci, 2019, 13: 194 | PMID: 31316360 | PMCID: PMC6611435
    Citations: 2 | AltScore: NA
  19. A Perspective on Objective Measurement of the Perceived Challenge of Walking.
    Chatterjee SA, Rose DK, Porges EC, Otzel DM, Clark DJ
    Front Hum Neurosci, 2019, 13: 161 | PMID: 31139069 | PMCID: PMC6527756
    Citations: | AltScore: NA
  20. Body weight, frailty, and chronic pain in older adults: a cross-sectional study.
    Chen C, Winterstein AG, Fillingim RB, Wei YJ
    BMC Geriatr, 2019 May 24, 19(1): 143 | PMID: 31126233 | PMCID: PMC6534872
    Citations: 1 | AltScore: NA
  21. Healthcare Utilization and Physical Functioning in Older Adults in the United States.
    Cheng Y, Goodin AJ, Pahor M, Manini T, Brown JD
    J Am Geriatr Soc, 2020 Feb, 68(2): 266-271 | PMID: 31755551
    Citations: 1 | AltScore: 26.9
  22. Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.
    Chimienti G, Picca A, Fracasso F, Marzetti E, Calvani R, Leeuwenburgh C, Russo F, Lezza AMS, Pesce V
    Int J Mol Sci, 2019 May 27, 20(10):
    pii: E2601. | PMID: 31137890 | PMCID: PMC6566948
    Citations: 3 | AltScore: 1
  23. HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice.
    Chittoor-Vinod VG, Bazick H, Todd AG, Falk D, Morelli KH, Burgess RW, Foster TC, Notterpek L
    ACS Chem Neurosci, 2019 Jun 19, 10(6): 2890-2902 | PMID: 31017387 | PMCID: PMC6588339
    Citations: | AltScore: NA
  24. Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults (Mind in Motion Study): Hypothesis, Theory, and Methods.
    Clark DJ, Manini TM, Ferris DP, Hass CJ, Brumback BA, Cruz-Almeida Y, Pahor M, Reuter-Lorenz PA, Seidler RD
    Front Aging Neurosci, 2019, 11: 358 | PMID: 31969814 | PMCID: PMC6960208
    Citations: | AltScore: NA
  25. Movement-evoked pain: transforming the way we understand and measure pain.
    Corbett DB, Simon CB, Manini TM, George SZ, Riley JL 3rd, Fillingim RB
    Pain, 2019 Apr, 160(4): 757-761 | PMID: 30371555 | PMCID: PMC6424644
    Citations: 7 | AltScore: 12.3
  26. Chronic pain is associated with a brain aging biomarker in community-dwelling older adults.
    Cruz-Almeida Y, Fillingim RB, Riley JL 3rd, Woods AJ, Porges E, Cohen R, Cole J
    Pain, 2019 May, 160(5): 1119-1130 | PMID: 31009418 | PMCID: PMC6752890
    Citations: 6 | AltScore: 207.8
  27. Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults.
    Cruz-Almeida Y, Sinha P, Rani A, Huo Z, Fillingim RB, Foster T
    Mol Pain, 2019 Jan-Dec, 15: 1744806919871819 | PMID: 31394966 | PMCID: PMC6710702
    Citations: 1 | AltScore: 6.65
  28. Prostate-Specific Antigen Levels During Testosterone Treatment of Hypogonadal Older Men: Data from a Controlled Trial.
    Cunningham GR, Ellenberg SS, Bhasin S, Matsumoto AM, Parsons JK, Preston P, Cauley JA, Gill TM, Swerdloff RS, Wang C, Ensrud KE, Lewis CE, Pahor M, Crandall JP, Molitch ME, Cifelli D, Basaria S, Diem SJ, Stephens-Shields AJ, Hou X, Snyder PJ
    J Clin Endocrinol Metab, 2019 Dec 1, 104(12): 6238-6246 | PMID: 31504596 | PMCID: PMC6823728
    Citations: 1 | AltScore: 5.45
  29. Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
    Custodero C, Wu Q, Ghita GL, Anton SD, Brakenridge SC, Brumback BA, Efron PA, Gardner AK, Leeuwenburgh C, Moldawer LL, Petersen JW, Moore FA, Mankowski RT
    Crit Care, 2019 Jun 24, 23(1): 230 | PMID: 31234943 | PMCID: PMC6589880
    Citations: 2 | AltScore: NA
  30. Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning.
    Davoudi A, Malhotra KR, Shickel B, Siegel S, Williams S, Ruppert M, Bihorac E, Ozrazgat-Baslanti T, Tighe PJ, Bihorac A, Rashidi P
    Sci Rep, 2019 May 29, 9(1): 8020 | PMID: 31142754 | PMCID: PMC6541714
    Citations: 1 | AltScore: 9.9
  31. Accuracy of Samsung Gear S Smartwatch for Activity Recognition: Validation Study.
    Davoudi A, Wanigatunga AA, Kheirkhahan M, Corbett DB, Mendoza T, Battula M, Ranka S, Fillingim RB, Manini TM, Rashidi P
    JMIR Mhealth Uhealth, 2019 Feb 6, 7(2): e11270 | PMID: 30724739 | PMCID: PMC6386649
    Citations: | AltScore: NA
  32. Impaired Ribosomal Biogenesis by Noncanonical Degradation of ?-Catenin during Hyperammonemia.
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    J Biopharm Stat, 2020, 30(1): 18-30 | PMID: 31135263 | PMCID: PMC6881517
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  34. Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood.
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  35. A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.
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  36. The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
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  37. Physical Activity and Performance Impact Long-term Quality of Life in Older Adults at Risk for Major Mobility Disability.
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  38. LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.
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  39. Mitochondrial respiration and H<sub>2</sub>O<sub>2</sub> emission in saponin-permeabilized murine diaphragm fibers: optimization of fiber separation and comparison to limb muscle.
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  40. Cognitive Function as a Predictor of Major Mobility Disability in Older Adults: Results From the LIFE Study.
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  41. Blood-Flow Restriction Resistance Exercise for Older Adults with Knee Osteoarthritis: A Pilot Randomized Clinical Trial.
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  42. Assessment of backward walking unmasks mobility impairments in post-stroke community ambulators.
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  43. Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity.
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  44. Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions.
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  45. MYOD1 functions as a clock amplifier as well as a critical co-factor for downstream circadian gene expression in muscle.
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  48. Oxytocin alters patterns of brain activity and amygdalar connectivity by age during dynamic facial emotion identification.
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  49. Resilience factors may buffer cellular aging in individuals with and without chronic knee pain.
    Johnson AJ, Terry E, Bartley EJ, Garvan C, Cruz-Almeida Y, Goodin B, Glover TL, Staud R, Bradley LA, Fillingim RB, Sibille KT
    Mol Pain, 2019 Jan-Dec, 15: 1744806919842962 | PMID: 30900507 | PMCID: PMC6484237
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  50. A smartwatch-based framework for real-time and online assessment and mobility monitoring.
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    J Biomed Inform, 2019 Jan, 89: 29-40 | PMID: 30414474 | PMCID: PMC6459185
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  51. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice.
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  52. Diabetes Technology Society Report on the FDA Digital Health Software Precertification Program Meeting.
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  53. Alteration in NMDA Receptor Mediated Glutamatergic Neurotransmission in the Hippocampus During Senescence.
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  55. Commentaries on Viewpoint: Rejuvenation of the term sarcopenia.
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  64. High-intensity exercise to promote accelerated improvements in cardiorespiratory fitness (HI-PACE): study protocol for a randomized controlled trial.
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  65. Discriminative Ability of Montreal Cognitive Assessment Subtests and Items in Racial and Ethnic Minority Groups.
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    Alzheimer Dis Assoc Disord, 2019 Jul-Sep, 33(3): 226-232 | PMID: 31058685 | PMCID: PMC6710139
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  66. Glycine supplementation extends lifespan of male and female mice.
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  68. Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.
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    Citations: 7 | AltScore: 26.45
  69. Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model.
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  70. Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial.
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  72. Disparities in the Use of Cardiac Rehabilitation after a Myocardial Infarction in the United States.
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  74. Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle.
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  76. Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease.
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  78. Pain inconsistency and sleep in mid to late-life: the role of depression.
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  79. Association of Adverse Drug Events with Hospitalization Outcomes and Costs in Older Adults in the USA using the Nationwide Readmissions Database.
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  83. Week-to-week predictors of weight loss and regain.
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  85. Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.
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  86. Effect of Gastric Acid Suppressants on Response to a Physical Activity Intervention and Major Mobility Disability in Older Adults: Results from the Lifestyle Interventions for Elders (LIFE) Study.
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    Pharmacotherapy, 2019 Aug, 39(8): 816-826 | PMID: 31230397
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  87. Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
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    Suchting R, Colpo GD, Rocha NP, Ahn H
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  90. Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness.
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  93. A comparison of accelerometry analysis methods for physical activity in older adult women and associations with health outcomes over time.
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  97. Health literacy, sociodemographic factors, and cognitive training in the active study of older adults.
    Verney SP, Gibbons LE, Dmitrieva NO, Kueider AM, Williams MW, Meyer OL, Manly JJ, Sisco SM, Marsiske M
    Int J Geriatr Psychiatry, 2019 Apr, 34(4): 563-570 | PMID: 30548889 | PMCID: PMC6557659
    Citations: 3 | AltScore: 2
  98. Magnitude of and Characteristics Associated With the Treatment of Calcium Channel Blocker-Induced Lower-Extremity Edema With Loop Diuretics.
    Vouri SM, Jiang X, Manini TM, Solberg LM, Pepine C, Malone DC, Winterstein AG
    JAMA Netw Open, 2019 Dec 2, 2(12): e1918425 | PMID: 31880802 | PMCID: PMC6991233
    Citations: | AltScore: 63.5
  99. Effect of Hospitalizations on Physical Activity Patterns in Mobility-Limited Older Adults.
    Wanigatunga AA, Gill TM, Marsh AP, Hsu FC, Yaghjyan L, Woods AJ, Glynn NW, King AC, Newton RL Jr, Fielding RA, Pahor M, Manini TM, Lifestyles Intervention and Independence for Elders Study Investigators.
    J Am Geriatr Soc, 2019 Feb, 67(2): 261-268 | PMID: 30452084 | PMCID: PMC6613645
    Citations: 1 | AltScore: 8.25
  100. Neural correlates of perceived physical and mental fatigability in older adults: A pilot study.
    Wasson E, Rosso AL, Santanasto AJ, Rosano C, Butters MA, Rejeski WJ, Boudreau RM, Aizenstein H, Gmelin T, Glynn NW, LIFE Study Group.
    Exp Gerontol, 2019 Jan, 115: 139-147 | PMID: 30528639 | PMCID: PMC6331252
    Citations: | AltScore: 1.5
  101. Trends in prescription opioid use and dose trajectories before opioid use disorder or overdose in US adults from 2006 to 2016: A cross-sectional study.
    Wei YJ, Chen C, Fillingim R, Schmidt SO, Winterstein AG
    PLoS Med, 2019 Nov, 16(11): e1002941 | PMID: 31689302 | PMCID: PMC6830744
    Citations: 1 | AltScore: 30
  102. Performance of the Centers for Medicare &amp; Medicaid Services' Opioid Overutilization Criteria for Classifying Opioid Use Disorder or Overdose.
    Wei YJ, Chen C, Sarayani A, Winterstein AG
    JAMA, 2019 Feb 12, 321(6): 609-611 | PMID: 30747958 | PMCID: PMC6439582
    Citations: 1 | AltScore: 36.1
  103. Trends in prior receipt of prescription opioid or adjuvant analgesics among patients with incident opioid use disorder or opioid-related overdose from 2006 to 2016.
    Wei YJ, Chen C, Schmidt SO, LoCiganic WH, Winterstein AG
    Drug Alcohol Depend, 2019 Nov 1, 204: 107600 | PMID: 31586806 | PMCID: PMC6927577
    Citations: | AltScore: NA
  104. Pain Assessments in MDS 3.0: Agreement with Vital Sign Pain Records of Nursing Home Residents.
    Wei YJ, Solberg L, Chen C, Fillingim RB, Pahor M, DeKosky S, Winterstein AG
    J Am Geriatr Soc, 2019 Nov, 67(11): 2421-2422 | PMID: 31403708 | PMCID: PMC6861605
    Citations: | AltScore: 4.7
  105. How do we validate approaches that aim to harness reserve to improve the aging brain?
    White LR, Boyle PA, Foster TC, Gazzaley AH, Disterhoft JF
    Neurobiol Aging, 2019 Nov, 83: 145-149 | PMID: 31732018 | PMCID: PMC6859906
    Citations: | AltScore: 1.6
  106. Expenditure variations analysis using residuals for identifying high health care utilizers in a state Medicaid program.
    Yang C, Delcher C, Shenkman E, Ranka S
    BMC Med Inform Decis Mak, 2019 Jul 12, 19(1): 131 | PMID: 31299965 | PMCID: PMC6626330
    Citations: | AltScore: NA
  107. MADEx: A System for Detecting Medications, Adverse Drug Events, and Their Relations from Clinical Notes.
    Yang X, Bian J, Gong Y, Hogan WR, Wu Y
    Drug Saf, 2019 Jan, 42(1): 123-133 | PMID: 30600484 | PMCID: PMC6402874
    Citations: 4 | AltScore: 0.75
  108. A Study of Deep Learning Methods for De-identification of Clinical Notes at Cross Institute Settings.
    Yang X, Lyu T, Lee CY, Bian J, Hogan WR, Wu Y
    IEEE Int Conf Healthc Inform, 2019 Jun, 2019: | PMID: 31879734 | PMCID: PMC6932867
    Citations: | AltScore: 0.25
  109. A study of deep learning methods for de-identification of clinical notes in cross-institute settings.
    Yang X, Lyu T, Li Q, Lee CY, Bian J, Hogan WR, Wu Y
    BMC Med Inform Decis Mak, 2019 Dec 5, 19(Suppl 5): 232 | PMID: 31801524 | PMCID: PMC6894104
    Citations: | AltScore: 0.75
  110. Effect of Systemic Inflammation on Rat Attentional Function and Neuroinflammation: Possible Protective Role for Food Restriction.
    Yegla B, Foster T
    Front Aging Neurosci, 2019, 11: 296 | PMID: 31708767 | PMCID: PMC6823289
    Citations: | AltScore: 2.75

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