UNIVERSITY OF FLORIDA
Claude D. Pepper Older Americans Independence Center

Principal Investigator    Marco Pahor, M.D.  352-294-5800  mpahor@ufl.edu
Program Administrator    Lauren Crump, MPH  352-294-5800  lcrump@ufl.edu
       
CENTER DESCRIPTION

The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons’ physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: “mobility and prevention of disability.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC’s general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: Leadership and Administrative Core; Research Education Core; Pilot/Exploratory Studies Core; Clinical Research Core; Metabolism and Translational Science Core; Biostatistics Core; and Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.

Research hypotheses:
  • Multiple biological, co-morbid, psychosocial, cognitive, and behavioral factors contribute to agerelated physical function decline, loss of mobility, and progression to disability.
  • Interventions that target individual or multiple biological, co-morbid, psychosocial, cognitive, and behavioral risk factors of physical function decline avert the loss of mobility and prevent disability.
Research objectives:
  • Assess, by taking advantage of a bidirectional translation between basic and clinical research, the multiple factors that contribute to physical function decline, loss of mobility, and progression to disability.
  • Develop and test pharmacological, nutritional, and behavioral interventions for preventing decline in physical function, loss of mobility, and progression to disability.
Educational objectives:
  • Educate and train new investigators in research on aging and disability in older adults.
  • Develop leadership qualities and roles in Junior Scholars supported by the OAIC.
  • Develop skills for translating findings between basic and clinical research.
Operational objectives:
  • To provide outstanding investigators and state-of-the-art resources, environment, and services to support the above-mentioned research and educational objectives.

CORES
Leadership and Administrative Core (LAC)
Leader 1:    Marco Pahor, MD   mpahor@ufl.edu
The Leadership and Administrative Core (LAC) is responsible for strategic planning, organization, administrative operations, and evaluation of the Older Americans Independence Center (OAIC) research and training program. A special effort is devoted to ensure the cohesion of the Center and maintain an interdisciplinary and translational research focus on the common research theme, which is “mobility and prevention of disability.” The Core Leader and three committees achieve the key LAC tasks. The Executive Committee, which is composed of the OAIC core leaders, administers, governs, provides scientific guidance, and sets productivity benchmarks for the OAIC. The External Advisory Board, which is composed of experts external to the institution, reviews all OAIC activities and provides overall scientific guidance to the OAIC. The Independent Review Panel, which is composed of ad hoc experts (at least one third external to the institution), reviews proposed support for development projects, and pilot/exploratory studies. Taken together, the LAC provides support for planning, organizational, evaluation, and administrative activities relating to the other cores and to the OAIC as a whole. The LAC monitors, stimulates, sustains, evaluates, and reports progress toward the overall goals of the OAIC.

Research Education Component (REC)
Leader 1:    Christiaan Leeuwenburgh, PhD   cleeuwen@ufl.edu
Leader 2:    Roger Fillingim, PhD   RFillingim@dental.ufl.edu
The REC promotes the development of independent investigators in interdisciplinary research on aging relevant to the independence of older Americans. One of our major goals is to identify the most promising Junior Scholars with research relevant to the OAIC theme at UF & VA and to provide them with mentorship, training activities, access to OAIC Core resources and funding and enable them to become independent investigators in interdisciplinary aging research. Furthermore, this core emphasizes the development of leadership, and research skills for translating basic findings into clinical research and clinical findings into basic research. The REC supports the research training of OAIC Junior Scholars that span the spectrum from beginning trainees who are not yet funded to advanced trainees who already have competed successfully for career development grants that provide substantial salary support.

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Yenisel Cruz-Almeida, Ph.D.   cryeni@ufl.edu
Leader 2:    Marco Pahor, MD   mpahor@ufl.edu
The Pilot/Exploratory Studies Core serves to develop key information needed to select and design future, original and independently funded studies that can advance our insight into sarcopenia and prevention of disability in older Americans. Specifically, the core fosters the Pilot and Exploratory studies by ensuring the availability of optimal infrastructure, environment, funding, expertise, and instrumentation. Pilot and Exploratory studies foster Junior Scholars in their efforts to develop research careers in aging by providing opportunities for meaningful participation in well-designed research studies and by collecting the needed preliminary data for independent research applications. Furthermore, these studies will allow investigators already accomplished in aging research to gather data that will extend and broaden their focus of research. Finally, these studies will also be a vehicle to encourage and facilitate experienced investigators traditionally working in other research fields to focus on aging.

Clinical Research Core (RC1)
Leader 1:    Stephen Anton, PhD   santon@ufl.edu
Leader 2:    Marco Pahor, MD   mpahor@ufl.edu

The Clinical Research Core (RC 1) is a key resource for the UF OAIC in providing the infrastructure and investigators for conducting clinical research -- randomized controlled trials and observational studies. The clinical research core has four primary goals: 1) optimal selection and utilization of measures for clinical trials and observational studies 2) understanding the physiological and biomechanical mechanisms contributing to changes in walking speed, 3) in collaboration with the Biostatistics Core, conduct secondary analyses of randomized clinical trials and observational studies to provide preliminary data to support the rationale for future clinical trials, and 4) development of behavioral and pharmacological interventions to improve physical function and quality of life of older adults. The RC 1 offers state-of the art infrastructure and experienced personnel to support the conduction of observational studies, and Phase 2 and 3 randomized controlled trials that involve behavioral and pharmacological interventions. Senior researchers with NIH and/or VA funding, who also have established track records as mentors for career development, lead each one of these goals.

 



Biostatistics Core (RC 3) (Biostats)
Leader 1:    Peihua Qiu, PhD   pqiu@ufl.edu
Leader 2:    Samuel Wu, PhD   samwu@ufl.edu

The Biostatistics Core is one of four research cores in the OAIC at UF. The mission of the OAIC at UF is to assess risk factors of physical disability in older adults, to develop and test effective prevention and rehabilitation therapies, and to train new investigators in research on aging and disability. The Biostatistics Core is a key cog in the interaction among scientists from many disciplines to accomplish this mission. The core provides data coordination including: developing data collection forms, designing web based capture systems, and managing the data (including quality control) for studies conducted within the OAIC. The core also is involved in all phases of these studies including initial study design and sample size calculations pre-proposal, randomization, and state-of-the-art statistical analyses once the data are completed. For study designs and data for which current methodology is lacking, the core has the expertise to develop new state of the art methodology to perform correct and appropriate analyses of data collected in the Center. The Biostatistics Core will also be involved in preparation of manuscripts for dissemination within the research community.  The Core also conducts research using The UF & Shands Academic Health Center’s new electronic medical record system (EPIC), which has gone live with new modules planned through the next few years.  This includes the implementation of a clinical data warehouse (CDW). The CDW is the foundation for the development of a research data repository whereby researchers and junior scholars and faculty may have unfettered access to anonymized data for clinic research.



Data Science and Applied Technology Core (RC 4) (Data Science)
Leader 1:    Todd Manini, PhD   tmanini@ufl.edu
Leader 2:    Sanjay Ranka, PhD   ranka@cise.ufl.edu

The Data Science and Applied Technology (DSAT) Core (RC4) provides an interactive data and technology ecosystem for preserving mobility and preventing disability. Big data initiatives, applied technologies, and new methodological approaches for data science have exploded in many various environments, and the world is moving toward a connected system of computing and sensing components. Additionally, mobile health (mHealth, smartphones and smartwatches) technologies are changing the landscape for how patients and research participants communicate about their health in real time. DSAT investigators provide OAIC leadership to assure that researchers in Geriatrics in general, mobility and disability are prepared for the rapid advances in these expanding technologies.  The RC4 provides many unique attributes, such as developing software for interactive mobile technology (e.g., wearable sensors that are programmable in real time); validating new sensing technology; warehousing data; repurposing data; and applying machine learning techniques to domain problems. DSAT provides a central hub of expertise in computer science, biomedical engineering, biomedical informatics, data science, applied technology, epidemiology, and content expertise in the assessment of mobility.  There is a growing demand for data science and applied technology for meeting the challenge of preserving mobility and preventing disability. The DSAT Core adds a highly innovative aspect to this challenge that will lead it into the future of connected systems of computing, sensing and biomedical informatics.



Metabolism and Translational Science (RC2) (Metabolism and Translational Science)
Leader 1:    Christiaan Leeuwenburgh, PhD   cleeuwen@ufl.edu

The Metabolism and Translational Science Core provides the infrastructure, laboratory space, trained personnel, consultative and collaborative scientific expertise and a wide spectrum of established and novel methodologies of biochemistry and molecular biology ( Western blot and Quantitative-PCR, quantitative-Real-Time PCR, enzyme-linked immunosorbent assays, multiplex immunoassays), high resolution respirometry, and selected measures of metabolism (i.e., ATP measures and enzymes activities of metabolism) that will address a set of genetic and biological themes focused on causes for aging and disability. The Core utilizes this state-of-the-art technology to determine specific mechanisms of aging and sarcopenia and the cause of reduced physical function present in elderly populations. The Core provides support for numerous independently funded studies, development projects, pilot studies and exploratory studies. Analyses of levels of biomarkers or cell signaling molecules will help to identify specific biological pathways of aging implicated in the development of sarcopenia. If the precise mechanisms underlying age-associated cellular deterioration can be identified, it will explain the loss of muscle mass and function with age and provide us with potential targets for intervention. In this context, we will also test if specific rehabilitation, physical activity and dietary interventions can attenuate biological pathways leading to aging and functional impairment. In addition, the Core supports preclinical phenotyping of various domains of function include Cognition, Physical, Motor, and Sensory/Hearing. Each of these sophisticated measures currently in use in our laboratories require expert oversight and the use of highly trained technicians. These assessment methodologies are conceptually similar to those used in humans and highly translatable.

 



CAREER DEVELOPMENT
REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications
 
Sung Min Han, PhD
Assistant Professor / College of Medicine Department of Aging and Geriatric Research
Investigating the role of mitochondria in the age-related decline of axon regeneration
2019-  0 (0 1st/Sr)

Past Scholars

PILOT/EXPLORATORY PROJECTS (5 Pilot Projects Listed)
1. Project Title: Time Course Adaptations using Deuterated Creatine (D3Cr) method
  Leader: Anoop Balachandran, PhD (Todd Manini, PhD)
 

This pilot study is focused on assessing the time course adaptions in functional muscle mass and performance outcomes in response to a high-intensity resistance training intervention in low functioning older adults.  It will provide critical clinical preliminary data for a successful extra-mural application for a future larger study. Specifically, the proposed future study will examine the impact of a high intensity resistance training intervention to increase skeletal muscle mass compared to an education control on physical performance outcomes, such as 400 m walk, lower body strength, balance, SPPB Short Physical Performance Battery (SPPB) in low functioning older adults.

 
2. Project Title: Circadian dysfunction in aging and chronic kidney disease
  Leader: Michelle Gumz, PhD (Karyn Esser, PhD)
 

The goal of this pilot study is to provide feasibility and supporting data for an R01 application. This new line of investigation is aimed at discerning mechanisms of and novel therapeutic interventions for chronic kidney disease. Chronic kidney disease is increasing in large part due to our aging population and it is associated with muscle wasting, decreased mobility, and increased disability. Our preliminary data for this pilot proposal strongly suggest that Dr. Esser’s unique mouse model of circadian disruption and accelerated aging has a renal defect. The funds requested in this application are necessary to test our hypothesis that circadian disruption and accelerated aging lead to kidney damage and reduced renal function. These funds are needed to provide supporting data for a larger, long-term project in which we will further test the hypothesis that circadian disruption and accelerated aging lead to chronic kidney disease with consequences for cardiovascular mortality.

 
3. Project Title: Exosomal Mediation of Exercise induced benefits in aging
  Leader: Brittney Yegla, PhD
 

The goal of this pilot study is to examine intercellular signaling, specifically exosomes and their miRNA content, in aging with exercised and non-exercised Fischer-344 rats. The study proposes to investigate age- and sex-related differences in exercise-induced exosome release following either an acute or sustained exercise regimen and how this relates to the changes in musculature, cognition, metabolism, inflammation, and redox state in multiple organs with exercise. Young and aged male and female rats will undergo treadmill running for a single bout of exercise (acute; Aim 1) or for two months on a progressive workload schedule (sustained; Aim 2) to produce a 70% VO2max. Following exercise rats will be evaluated for physical and cognitive capacity changes compared to sedentary controls. After   final bout of exercise, rats will be euthanized, and the blood, muscle, liver, kidney, brain, and fat tissue will be collected to examine the impact of age, sex, and exercise on exosome-derived miRNA expression and metabolic and inflammatory marker levels. Regular sustained exercise is expected to produce quantitative and qualitative changes in exosome-derived miRNA expression, correlating with cellular, cognitive, and physical changes. It is predicted that continued exercise will shift the aging secretome to resemble a younger profile. The findings from this study will not only establish the foundation for future NIH-funded experiments but also provide critical insight into age-related shifts in intercellular signaling and its sensitivity and responsiveness to exercise.

 
4. Project Title: Identification of novel circulating factors affecting skeletal muscle mass & function in advanced age
  Leader: Russell T. Hepple, PhD
 

This pilot study aims to identify novel circulating (blood-borne) factors that can promote physical function and maintenance of skeletal muscle mass and function in advanced age. We will capitalize on substantial pre-existing data, banked blood serum and banked myoblast cultures that we collected in recent studies examining world-class octogenarian track & field athletes as a model of very healthy aging. We will complement this with study of pre-frail/frail elderly individuals with the objective of identifying both positive circulating factors (e.g., those found in serum of world class octogenarian athletes) and negative circulating factors (e.g., those found in serum of pre-frail/frail elderly) by doing advanced proteomics screening of serum from these subjects. Additionally, we will conduct preliminary evaluation of promising candidate proteins enriched in high functioning (octogenarian athletes) versus low functioning (pre-frail/frail elderly) individuals by screening for muscle and neuromuscular junction impact using human myoblast cultures. These highly novel and exciting studies will directly address factors that likely contribute to mobility and disability with aging.

 
5. Project Title: Estrogen and Prevention of Hearing Loss
  Leader: Shinichi Someya, PhD
 

Numerous studies have reported gender differences in human auditory function. In general, the results of these studies show that women of virtually all ages demonstrate better hearing than men5-13. Considerable evidence also suggests that auditory function is diminished following menopause14-15, whereas estrogen therapy prevents decline of auditory function in postmenopausal women16-20. Estrogen also has neuroprotective and glutathione antioxidant defense actions21-24. However, the molecular mechanisms underlying these beneficial effects are largely unknown and prescribing estrogen therapy to women experiencing hearing problems remains controversial25-27. The central hypothesis of our research proposal is that estrogen protects hearing by enhancing glutathione transferase detoxification in the auditory system of females over the lifespan. The results of our proposed work will provide women, suffering from post-menopausal hearing loss, practical approaches to prevent decline of auditory function and disability associated with hearing loss.

 
DEVELOPMENT PROJECTS (0 Development Projects Listed)
  No development projects.
RESEARCH (10 Projects Listed)
1. Project Title: AEROBIC EXERCISE AND COGNITIVE TRAINING IN OLDER ADULTS
  Leader(s): NOCERA, JOE ROBERT
    VETERANS HEALTH ADMINISTRATION
    VA IK2RX000744 / (2012-2018)
  Core(s):
  DESCRIPTION This proposal, 'Aerobic Exercise and Cognitive Training in Older Adults', is resubmission for a Career Development Award- Level 2 with Dr. Joe R. Nocera as the Principal Investigator and a mentoring team of Drs. Bruce Crosson, Ron Shorr, Marco Pahor and Michael Marsiske. Dr. Nocera received his undergraduate degree (B.A., 2001) from the University of California, Los Angeles. He c...
 
2. Project Title: INVESTIGATIONS OF BOTANICALS ON FOOD INTAKE, SATIETY, WEIGHT LOSS, AND OXIDATIVE
  Leader(s): ANTON, STEPHEN D
    UNIVERSITY OF FLORIDA
    NIH K23AT004251 / (2009-2014)
  Core(s):
  DESCRIPTION (provided by applicant): My training to date has provided me with a solid understanding of the behavioral, psychosocial, and environmental factors that contribute to eating behavior and weight management; however, my understanding of physiology and the biological mechanisms regulating eating behavior and body weight remains to be improved. Therefore, I seek to increase my knowledge ...
 
3. Project Title: PICS: A NEW HORIZON FOR SURGICAL CRITICAL CARE
  Leader(s): MOORE, FREDERICK A
    UNIVERSITY OF FLORIDA
    NIH P50GM111152 / (2014-2019)
  Core(s):
  DESCRIPTION (provided by applicant): Despite 30 years of intensive research, morbidity and mortality of sepsis in surgical intensive care unit (ICU) patients remain unacceptably high. Although recent advances in early ICU care have reduced in-hospital mortality, with the aging population a new epidemic of chronic critical illness (CCI) has emerged and its progression into what we call the persi...
 
4. Project Title: REVIVE - RESVERATROL TO ENHANCE VITALITY AND VIGOR IN ELDERS
  Leader(s): ANTON, STEPHEN D
    UNIVERSITY OF FLORIDA
    NIH R01AT007564 / (2013-2019)
  Core(s):
  A large and growing number of older adults experience progressive declines in physical function, culminating in age-related physical disability with no clear connection to a single disease. Although the etiology of age-related physical disability is complex and multi-factorial, emerging evidence implicates the mitochondria as playing a key role in the initial onset and progression of functional de...
 
5. Project Title: AUTOPHAGY IN LIVER INJURY
  Leader(s): KIM, JAE-SUNG
    WASHINGTON UNIVERSITY
    NIH R01DK079879 / (2007-2020)
  Core(s):
  DESCRIPTION (provided by applicant): Mitochondrial dysfunction is the major mechanism precipitating I/R injury which commonly occurs during liver surgery, trauma, hemorrhagic shock and liver transplantation. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that induces longevity, stress resistance and tumor suppression. The role of SIRT1 in ischemia/reperfusion-mediated liver injury is unknown. ...
 
6. Project Title: HEMATOPOIETIC STEM CELL DYSFUNCTION IN THE ELDERLY AFTER SEVERE INJURY
  Leader(s): EFRON, PHILIP A
    UNIVERSITY OF FLORIDA
    NIH R01GM113945 / (2015-2020)
  Core(s):
  DESCRIPTION (provided by applicant): People of advanced age (greater than 55 years old) have significantly increased morbidity and mortality after trauma. Since the elderly population is expanding, research into this disease process is increasingly relevant, especially with the escalating economic and health care burdens on our society. Despite decades of promising preclinical and clini...
 
7. Project Title: HEAT SHOCK PROTEINS AND DISUSE MUSCLE ATROPHY
  Leader(s): JUDGE, ANDREW ROBERT
    UNIVERSITY OF FLORIDA
    NIH R03AR056418 / (2009-2013)
  Core(s):
  DESCRIPTION (provided by applicant): Project summary/Abstract Skeletal muscle disuse atrophy is a widespread physiological phenomenon associated with immobilization, bed rest, denervation, and space flight, or any general reduction in weight bearing activity. However, our understanding of the signaling molecules that regulate muscle mass during disuse are ill defined. Therefore the long-range ...
 
8. Project Title: NICOTINAMIDE RIBOSIDE AS AN ENHANCER OF EXERCISE THERAPY IN HYPERTENSIVE OLDER ADULTS: THE NEET TRIAL
  Leader(s): MANKOWSKI, ROBERT
    UNIVERSITY OF FLORIDA
    NIH R21AG064282 / (2019-2021)
  Core(s):
  ABSTRACTMore than 80% of older adults have hypertension, with higher prevalence of high systolic blood pressure (SBP)putting them at high risk for cardiovascular (CV) disease and death. Because drug therapy that lowers SBP isassociated with side effects such as hypotension, syncope, and kidney dysfunction, there is a great need foreffective lifestyle SBP-lowering interventions for the older popula...
 
9. Project Title: DYSREGULATION OF SARCOMERE STABILIZING PROTEINS CAUSE MUSCLE ATROPHY AND WEAKNESS DURING CANCER CACHEXIA
  Leader(s): JUDGE, ANDREW ROBERT
    UNIVERSITY OF FLORIDA
    NIH R21CA194118 / (2015-2018)
  Core(s):
  DESCRIPTION (provided by applicant): Cachexia is characterized by progressive skeletal muscle and body weight loss and affects up to 80% of cancer patients. This loss of muscle mass contributes to significant muscle weakness and diminished physical function and is associated with reduced tolerance to chemotherapy and increased complications from surgical/radiotherapeutic treatments. Con...
 
10. Project Title: THE ENRGISE STUDY
  Leader(s): PAHOR, MARCO; AMBROSIUS, WALTER T ;
    UNIVERSITY OF FLORIDA
    NIH U01AG050499 / (2015-2019)
  Core(s):
  DESCRIPTION (provided by applicant): Growing evidence from our group and others shows that low-grade chronic inflammation, characterized by elevations in plasma C-reactive protein, tumor necrosis factor alpha, and particularly Interleukin-6 (IL-6), is an independent risk factor o disability, impaired mobility, and lower walking speed. Low-grade chronic inflammation is a modifiable risk ...
 
PUBLICATIONS
2021
 
2020
  1. A Simulated Graphical Interface for Integrating Patient-Generated Health Data From Smartwatches With Electronic Health Records: Usability Study.
    Alpert JM, Kota NSP, Ranka S, Mendoza TV, Solberg LM, Rashidi P, Manini TM
    JMIR Hum Factors, 2020 Oct 30, 7(4): e19769
    https://doi.org/10.2196/19769 | PMID: 33124988 | PMCID: PMC7665942
    Citations: | AltScore: NA
  2. Innovations in Geroscience to enhance mobility in older adults.
    Anton SD, Cruz-Almeida Y, Singh A, Alpert J, Bensadon B, Cabrera M, Clark DJ, Ebner NC, Esser KA, Fillingim RB, Goicolea SM, Han SM, Kallas H, Johnson A, Leeuwenburgh C, Liu AC, Manini TM, Marsiske M, Moore F, Qiu P, Mankowski RT, Mardini M, McLaren C, Ranka S, Rashidi P, Saini S, Sibille KT, Someya S, Wohlgemuth S, Tucker C, Xiao R, Pahor M
    Exp Gerontol, 2020 Dec, 142: 111123
    https://doi.org/10.1016/j.exger.2020.111123 | PMID: 33191210 | PMCID: PMC7581361
    Citations: | AltScore: NA
  3. Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
    Balachandran A, Gundermann DM, Walkup MP, King AC, Ambrosius WT, Kritchevsky SB, Pahor M, Newman AB, Manini TM
    Med Sci Sports Exerc, 2020 Apr, 52(4): 859-867
    https://doi.org/10.1249/MSS.0000000000002195 | PMID: 31688650 | PMCID: PMC7123515
    Citations: | AltScore: 4.85
  4. Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
    Brown JD, Alipour-Haris G, Pahor M, Manini TM
    J Clin Med, 2020 Nov 22, 9(11):
    pii: E3757. https://doi.org/10.3390/jcm9113757 | PMID: 33266358 | PMCID: PMC7700674
    Citations: | AltScore: 1.85
  5. Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.
    Brown JD, Lo-Ciganic WH, Shao H, Pahor M, Manini TM
    J Clin Med, 2020 Jul 22, 9(8):
    pii: E2332. https://doi.org/10.3390/jcm9082332 | PMID: 32707877 | PMCID: PMC7465072
    Citations: | AltScore: NA
  6. Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic.
    Brown JD, Vouri SM, Manini TM
    Res Social Adm Pharm, 2020 Nov 12
    pii: S1551-7411(20)31190-6. https://doi.org/10.1016/j.sapharm.2020.11.005 | PMID: 33221267 | PMCID: PMC7659512
    Citations: | AltScore: 12.78
  7. Pain, aging, and the brain: new pieces to a complex puzzle.
    Cruz-Almeida Y, Cole J
    Pain, 2020 Mar, 161(3): 461-463
    https://doi.org/10.1097/j.pain.0000000000001757 | PMID: 31764392 | PMCID: PMC7134332
    Citations: 1 | AltScore: 6
  8. The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study.
    Custodero C, Anton SD, Beavers DP, Mankowski RT, Lee SA, McDermott MM, Fielding RA, Newman AB, Tracy RP, Kritchevsky SB, Ambrosius WT, Pahor M, Manini TM, ENRGISE study investigators.
    Arch Gerontol Geriatr, 2020 Sep - Oct, 90: 104131
    https://doi.org/10.1016/j.archger.2020.104131 | PMID: 32554219 | PMCID: PMC7434645
    Citations: | AltScore: 0.5
  9. Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
    Darden DB, Stortz JA, Hollen MK, Cox MC, Apple CG, Hawkins RB, Rincon JC, Lopez MC, Wang Z, Navarro E, Hagen JE, Parvataneni HK, Brusko MA, Kladde M, Bacher R, Brumback BA, Brakenridge SC, Baker HV, Cogle CR, Mohr AM, Efron PA
    Front Immunol, 2020, 11: 1289
    https://doi.org/10.3389/fimmu.2020.01289 | PMID: 32670283 | PMCID: PMC7326804
    Citations: | AltScore: 0.75
  10. Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.
    Febo M, Rani A, Yegla B, Barter J, Kumar A, Wolff CA, Esser K, Foster TC
    Front Aging Neurosci, 2020, 12: 34
    https://doi.org/10.3389/fnagi.2020.00034 | PMID: 32153384 | PMCID: PMC7044155
    Citations: 1 | AltScore: 4
  11. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
    Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB, Lifestyle Interventions and Independence for Elders Study Group.
    J Am Geriatr Soc, 2020 Mar, 68(3): 619-624
    https://doi.org/10.1111/jgs.16274 | PMID: 31867713
    Citations: | AltScore: 22.45
  12. MicroRNA predicts cognitive performance in healthy older adults.
    Gullett JM, Chen Z, O'Shea A, Akbar M, Bian J, Rani A, Porges EC, Foster TC, Woods AJ, Modave F, Cohen RA
    Neurobiol Aging, 2020 Nov, 95: 186-194
    https://doi.org/10.1016/j.neurobiolaging.2020.07.023 | PMID: 32846274 | PMCID: PMC7606424
    Citations: 1 | AltScore: NA
  13. A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats.
    Hernandez AR, Winesett SP, Federico QP, Williams SA, Burke SN, Clark DJ
    Front Aging Neurosci, 2020, 12: 276
    https://doi.org/10.3389/fnagi.2020.00276 | PMID: 32982717 | PMCID: PMC7492995
    Citations: | AltScore: NA
  14. Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan.
    Kim MJ, Han C, White K, Park HJ, Ding D, Boyd K, Rothenberger C, Bose U, Carmichael P, Linser PJ, Tanokura M, Salvi R, Someya S
    Exp Gerontol, 2020 Nov, 141: 111078
    https://doi.org/10.1016/j.exger.2020.111078 | PMID: 32866605 | PMCID: PMC7680416
    Citations: | AltScore: NA
  15. Determinants of Adherence in Time-Restricted Feeding in Older Adults: Lessons from a Pilot Study.
    Lee SA, Sypniewski C, Bensadon BA, McLaren C, Donahoo WT, Sibille KT, Anton S
    Nutrients, 2020 Mar 24, 12(3):
    pii: E874. https://doi.org/10.3390/nu12030874 | PMID: 32213965 | PMCID: PMC7146127
    Citations: 2 | AltScore: 1
  16. Delayed interhospital transfer of critically ill patients with surgical sepsis.
    Loftus TJ, Wu Q, Wang Z, Lysak N, Moore FA, Bihorac A, Efron PA, Mohr AM, Brakenridge SC
    J Trauma Acute Care Surg, 2020 Jan, 88(1): 169-175
    https://doi.org/10.1097/TA.0000000000002476 | PMID: 31856021 | PMCID: PMC6927529
    Citations: | AltScore: 17.2
  17. Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
    Mankowski RT, Anton SD, Ghita GL, Brumback B, Cox MC, Mohr AM, Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA
    J Am Geriatr Soc, 2020 Apr 15, 68(9): 1962-1969
    https://doi.org/10.1111/jgs.16435 | PMID: 32294254 | PMCID: PMC7654284
    Citations: 1 | AltScore: 5.6
  18. Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults - A pilot study.
    Mankowski RT, You L, Buford TW, Leeuwenburgh C, Manini TM, Schneider S, Qiu P, Anton SD
    Exp Gerontol, 2020 Mar, 131: 110821
    https://doi.org/10.1016/j.exger.2019.110821 | PMID: 31891746
    Citations: 3 | AltScore: 10.65
  19. Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
    Pahor M, Guralnik JM, Anton SD, Ambrosius WT, Blair SN, Church TS, Espeland MA, Fielding RA, Gill TM, Glynn NW, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Williamson JD
    J Am Geriatr Soc, 2020 Apr, 68(4): 872-881
    https://doi.org/10.1111/jgs.16365 | PMID: 32105353 | PMCID: PMC7187344
    Citations: 2 | AltScore: 13
  20. Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
    Park HJ, Kim MJ, Han C, White K, Ding D, Boyd K, Salvi R, Someya S
    Exp Gerontol, 2020 May, 133: 110872
    https://doi.org/10.1016/j.exger.2020.110872 | PMID: 32044382 | PMCID: PMC7062562
    Citations: 1 | AltScore: NA
  21. Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.
    Pehlivanoglu D, Myers E, Ebner NC
    Biol Psychol, 2020 Jul, 154: 107917
    https://doi.org/10.1016/j.biopsycho.2020.107917 | PMID: 32512020 | PMCID: PMC7556712
    Citations: | AltScore: 1.6
  22. Reliability and Validity of the Short-Form 12 Item Version 2 (SF-12v2) Health-Related Quality of Life Survey and Disutilities Associated with Relevant Conditions in the U.S. Older Adult Population.
    Shah CH, Brown JD
    J Clin Med, 2020 Feb 29, 9(3):
    pii: E661. https://doi.org/10.3390/jcm9030661 | PMID: 32121371 | PMCID: PMC7141358
    Citations: 1 | AltScore: 1.85
  23. Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
    Smith G, Rani A, Kumar A, Barter J, Foster TC
    J Neurosci, 2020 Jun 17, 40(25): 4888-4899
    https://doi.org/10.1523/JNEUROSCI.2944-19.2020 | PMID: 32376783 | PMCID: PMC7326352
    Citations: | AltScore: 20.35
  24. Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.
    Someya S, Kim MJ
    Hear Res, 2020 May 28 108002
    https://doi.org/10.1016/j.heares.2020.108002 | PMID: 32600853 | PMCID: PMC7704621
    Citations: | AltScore: NA
  25. Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
    Squires P, Pahor M, Manini TM, Vouri S, Brown JD
    J Clin Med, 2020 Sep 16, 9(9):
    pii: E2989. https://doi.org/10.3390/jcm9092989 | PMID: 32947839 | PMCID: PMC7564216
    Citations: | AltScore: NA
  26. Neuropathic-Like Pain Symptoms in a Community-Dwelling Sample with or at Risk for Knee Osteoarthritis.
    Terry EL, Booker SQ, Cardoso JS, Sibille KT, Bartley EJ, Glover TL, Vaughn IA, Thompson KA, Bulls HW, Addison AS, Staud R, Hughes LB, Edberg JC, Redden DT, Bradley LA, Goodin BR, Fillingim RB
    Pain Med, 2020 Jan 1, 21(1): 125-137
    https://doi.org/10.1093/pm/pnz112 | PMID: 31150093 | PMCID: PMC6953341
    Citations: 1 | AltScore: 3.85


EXTERNAL ADVISORY BOARD MEMBERS

No EAB Members specified.

RECOGNITION AND AWARDS (2020-2021)

Recognition and Awards not specified.

MINORITY RESEARCH

General Brief Description of Minority Activities:

Steve Anton, PhD

·      Co-PI R33 AG056540: “The University of Florida Jacksonville Aging Studies Center (JAXASCENT)

·      Mentor for minority junior faculty member, Latoya O’Neal, Ph.D. (2017)

 

Yenisel Cruz-Almeida, MSPH, PhD

·      Pedro Valdes Hernandez, PhD- T32 Mentor

·      Soamy Montesino Goicolea, MD- Mentor

·      Carolina Maciel, MD- Junior Pepper Scholar Mentor

·      Desiree Lussier, PhD- Mentor

·      Keesha Roach, BSN, PhD- T32 Mentor

·      Sophia McCray- Honors Thesis Mentor

·      Vanessa Davila- Honors Thesis Mentor

·      Lorraine Hoyos- Medical Student, UCF, Research Mentor

 

Roger Fillingim, PhD

P30AG059297: “University of Florida Resource Center for Minority Aging Research

 

Todd Manini, PhD, Mentor 

·      Dottington Fullwood, PhD

 

Marco Pahor, MD

·      Co-PI R33 AG056540: “The University of Florida Jacksonville Aging Studies Center (JAXASCENT)

 

Carolyn Tucker, PhD

·      Human Foundation: “Health-Smart, Holistic Health and Wellness Centers Program to Promote Social Connection and Food Security among Minority, Underserved, and/or Low- Income Jacksonville Seniors”

 

·      PCORI: “Culturally Sensitive Primary Care Clinic-Based Interventions”




No minority trainee information specified.

No minority grant information specified.