UNIVERSITY OF FLORIDA
Claude D. Pepper Older Americans Independence Center

Principal Investigator    Marco Pahor, M.D.  352-294-5800  mpahor@ufl.edu
Program Administrator    Connie Caudle  352-294-5800  ccaudle@ufl.edu
       
CENTER DESCRIPTION

The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons’ physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: “mobility and prevention of disability.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC’s general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: Leadership and Administrative Core; Research Education Core; Pilot/Exploratory Studies Core; Clinical Research Core; Metabolism and Translational Science Core; Biostatistics Core; and Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.

Research hypotheses:
  • Multiple biological, co-morbid, psychosocial, cognitive, and behavioral factors contribute to agerelated physical function decline, loss of mobility, and progression to disability.
  • Interventions that target individual or multiple biological, co-morbid, psychosocial, cognitive, and behavioral risk factors of physical function decline avert the loss of mobility and prevent disability.
Research objectives:
  • Assess, by taking advantage of a bidirectional translation between basic and clinical research, the multiple factors that contribute to physical function decline, loss of mobility, and progression to disability.
  • Develop and test pharmacological, nutritional, and behavioral interventions for preventing decline in physical function, loss of mobility, and progression to disability.
Educational objectives:
  • Educate and train new investigators in research on aging and disability in older adults.
  • Develop leadership qualities and roles in Junior Scholars supported by the OAIC.
  • Develop skills for translating findings between basic and clinical research.
Operational objectives:
  • To provide outstanding investigators and state-of-the-art resources, environment, and services to support the above-mentioned research and educational objectives.

CORES
Leadership and Administrative Core (LAC)
Leader 1:    Marco Pahor, MD   mpahor@ufl.edu
The Leadership and Administrative Core (LAC) is responsible for strategic planning, organization, administrative operations, and evaluation of the Older Americans Independence Center (OAIC) research and training program. A special effort is devoted to ensure the cohesion of the Center and maintain an interdisciplinary and translational research focus on the common research theme, which is “mobility and prevention of disability.” The Core Leader and three committees achieve the key LAC tasks. The Executive Committee, which is composed of the OAIC core leaders, administers, governs, provides scientific guidance, and sets productivity benchmarks for the OAIC. The External Advisory Board, which is composed of experts external to the institution, reviews all OAIC activities and provides overall scientific guidance to the OAIC. The Independent Review Panel, which is composed of ad hoc experts (at least one third external to the institution), reviews proposed support for development projects, and pilot/exploratory studies. Taken together, the LAC provides support for planning, organizational, evaluation, and administrative activities relating to the other cores and to the OAIC as a whole. The LAC monitors, stimulates, sustains, evaluates, and reports progress toward the overall goals of the OAIC.

Research Education Component (REC)
Leader 1:    Christiaan Leeuwenburgh, PhD   cleeuwen@ufl.edu
Leader 2:    Roger Fillingim, PhD   RFillingim@dental.ufl.edu
The REC promotes the development of independent investigators in interdisciplinary research on aging relevant to the independence of older Americans. One of our major goals is to identify the most promising Junior Scholars with research relevant to the OAIC theme at UF & VA and to provide them with mentorship, training activities, access to OAIC Core resources and funding and enable them to become independent investigators in interdisciplinary aging research. Furthermore, this core emphasizes the development of leadership, and research skills for translating basic findings into clinical research and clinical findings into basic research. The REC supports the research training of OAIC Junior Scholars that span the spectrum from beginning trainees who are not yet funded to advanced trainees who already have competed successfully for career development grants that provide substantial salary support.

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Yenisel Cruz-Almeida, Ph.D.   cryeni@ufl.edu
Leader 2:    Marco Pahor, MD   mpahor@ufl.edu
The Pilot/Exploratory Studies Core serves to develop key information needed to select and design future, original and independently funded studies that can advance our insight into sarcopenia and prevention of disability in older Americans. Specifically, the core fosters the Pilot and Exploratory studies by ensuring the availability of optimal infrastructure, environment, funding, expertise, and instrumentation. Pilot and Exploratory studies foster Junior Scholars in their efforts to develop research careers in aging by providing opportunities for meaningful participation in well-designed research studies and by collecting the needed preliminary data for independent research applications. Furthermore, these studies will allow investigators already accomplished in aging research to gather data that will extend and broaden their focus of research. Finally, these studies will also be a vehicle to encourage and facilitate experienced investigators traditionally working in other research fields to focus on aging.

Clinical Research Core (RC1)
Leader 1:    Stephen Anton, PhD   santon@ufl.edu
Leader 2:    Marco Pahor, MD   mpahor@ufl.edu

The Clinical Research Core (RC 1) is a key resource for the UF OAIC in providing the infrastructure and investigators for conducting clinical research -- randomized controlled trials and observational studies. The clinical research core has four primary goals: 1) optimal selection and utilization of measures for clinical trials and observational studies 2) understanding the physiological and biomechanical mechanisms contributing to changes in walking speed, 3) in collaboration with the Biostatistics Core, conduct secondary analyses of randomized clinical trials and observational studies to provide preliminary data to support the rationale for future clinical trials, and 4) development of behavioral and pharmacological interventions to improve physical function and quality of life of older adults. The RC 1 offers state-of the art infrastructure and experienced personnel to support the conduction of observational studies, and Phase 2 and 3 randomized controlled trials that involve behavioral and pharmacological interventions. Senior researchers with NIH and/or VA funding, who also have established track records as mentors for career development, lead each one of these goals.

 



Biostatistics Core (RC 3) (Biostats)
Leader 1:    Peihua Qiu, PhD   pqiu@ufl.edu
Leader 2:    Rhonda Bacher, PhD   rbacher@ufl.edu

The Biostatistics Core is one of four research cores in the OAIC at UF. The mission of the OAIC at UF is to assess risk factors of physical disability in older adults, to develop and test effective prevention and rehabilitation therapies, and to train new investigators in research on aging and disability. The Biostatistics Core is a key cog in the interaction among scientists from many disciplines to accomplish this mission. The core provides data coordination including: developing data collection forms, designing web based capture systems, and managing the data (including quality control) for studies conducted within the OAIC. The core also is involved in all phases of these studies including initial study design and sample size calculations pre-proposal, randomization, and state-of-the-art statistical analyses once the data are completed. For study designs and data for which current methodology is lacking, the core has the expertise to develop new state of the art methodology to perform correct and appropriate analyses of data collected in the Center. The Biostatistics Core will also be involved in preparation of manuscripts for dissemination within the research community.  The Core also conducts research using The UF & Shands Academic Health Center’s new electronic medical record system (EPIC), which has gone live with new modules planned through the next few years.  This includes the implementation of a clinical data warehouse (CDW). The CDW is the foundation for the development of a research data repository whereby researchers and junior scholars and faculty may have unfettered access to anonymized data for clinic research.



Data Science and Applied Technology Core (RC 4) (Data Science)
Leader 1:    Todd Manini, PhD   tmanini@ufl.edu
Leader 2:    Sanjay Ranka, PhD   ranka@cise.ufl.edu

The Data Science and Applied Technology (DSAT) Core (RC4) provides an interactive data and technology ecosystem for preserving mobility and preventing disability. Big data initiatives, applied technologies, and new methodological approaches for data science have exploded in many various environments, and the world is moving toward a connected system of computing and sensing components. Additionally, mobile health (mHealth, smartphones and smartwatches) technologies are changing the landscape for how patients and research participants communicate about their health in real time. DSAT investigators provide OAIC leadership to assure that researchers in Geriatrics in general, mobility and disability are prepared for the rapid advances in these expanding technologies.  The RC4 provides many unique attributes, such as developing software for interactive mobile technology (e.g., wearable sensors that are programmable in real time); validating new sensing technology; warehousing data; repurposing data; and applying machine learning techniques to domain problems. DSAT provides a central hub of expertise in computer science, biomedical engineering, biomedical informatics, data science, applied technology, epidemiology, and content expertise in the assessment of mobility.  There is a growing demand for data science and applied technology for meeting the challenge of preserving mobility and preventing disability. The DSAT Core adds a highly innovative aspect to this challenge that will lead it into the future of connected systems of computing, sensing and biomedical informatics.



Metabolism and Translational Science (RC2) (Metabolism and Translational Science)
Leader 1:    Christiaan Leeuwenburgh, PhD   cleeuwen@ufl.edu

The Metabolism and Translational Science Core provides the infrastructure, laboratory space, trained personnel, consultative and collaborative scientific expertise and a wide spectrum of established and novel methodologies of biochemistry and molecular biology ( Western blot and Quantitative-PCR, quantitative-Real-Time PCR, enzyme-linked immunosorbent assays, multiplex immunoassays), high resolution respirometry, and selected measures of metabolism (i.e., ATP measures and enzymes activities of metabolism) that will address a set of genetic and biological themes focused on causes for aging and disability. The Core utilizes this state-of-the-art technology to determine specific mechanisms of aging and sarcopenia and the cause of reduced physical function present in elderly populations. The Core provides support for numerous independently funded studies, development projects, pilot studies and exploratory studies. Analyses of levels of biomarkers or cell signaling molecules will help to identify specific biological pathways of aging implicated in the development of sarcopenia. If the precise mechanisms underlying age-associated cellular deterioration can be identified, it will explain the loss of muscle mass and function with age and provide us with potential targets for intervention. In this context, we will also test if specific rehabilitation, physical activity and dietary interventions can attenuate biological pathways leading to aging and functional impairment. In addition, the Core supports preclinical phenotyping of various domains of function include Cognition, Physical, Motor, and Sensory/Hearing. Each of these sophisticated measures currently in use in our laboratories require expert oversight and the use of highly trained technicians. These assessment methodologies are conceptually similar to those used in humans and highly translatable.

 



CAREER DEVELOPMENT
REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications
 
Sung Min Han, PhD
Assistant Professor / College of Medicine Department of Aging and Geriatric Research
Investigating the role of mitochondria in the age-related decline of axon regeneration
Aging, axon regeneration, mobility, mitochondria, DLK-1 MAPK pathway, C. elegans, RNAseq.
  • AFAR AGR00015406

2019-2021  3 (0 1st/Sr)
Carolina Maciel, MD
Assistant Professor / Department of Neurology, Division of Neurocritical Care
“Brain tsunamis after cardiac arrest and microcirculatory failure in aging brains”
Key Words: Cardiac arrest, terminal depolarization, neurovascular coupling, spreading depolarization.
2019-2021  12 (0 1st/Sr)
Scott Vouri, PharmD, MSCI, PhD
Assistant Professor / Department of Pharmaceutical Outcomes and Policy
Preventing and eliminating the calcium channel blocker –lower extremity edema –loop diuretic prescribing cascade in older adults
Key Words: Prescribing cascades, calcium channel blocker, loop diuretic, adverse event, functionality and mobility.
  • NIH K08AG066854

2019-2021  9 (0 1st/Sr)
Matthew R. Burns, MD, PhD
Assistant Professor / Department of Neurology
Project Title: Mesocorticolimbic Dysfunction and Modulation in Aging and Synucleinopathy
Key Words: Mesocorticolimbic, cognitive function, synucleinopathy
  • K08

2020-2022  0 (0 1st/Sr)
Sudeshina A. Chatterjee, BPTh, MS, PhD
Assistant Professor / Department of Physical Therapy and Rehabilitation Science
Investing COMT Genotype Association with Mobility Decline and Falls in Older Adults
Key Words: Complex walking, fall risk, prefrontal cortex, genetics, precision medicine
2020-2022  0 (0 1st/Sr)
Mamoun Mardini, PhD
Assistant Professor / Department of Aging and Geriatric Research
Project Title: Developing an EHR-Based Frailty Index Using Machine Learning Approaches
Key Words: Frailty, machine learning, pre-operative screening, outcomes, decision-aid
2020-2022  0 (0 1st/Sr)
Samir K. Shah, MD, MPH
Assistant Professor / Department of Surgery
Patient-Centered Outcomes After Abdominal Aortic Aneurysm Surgery
Key Words: Patient-centered outcomes, aging, mobility, wearables, ecological momentary assessment of symptoms, aortic aneurysms
2020-2022  0 (0 1st/Sr)

Past Scholars
Dr. Rui Xiao, Department of Aging & Geriatric Research (2015-2017)
Hyochol "Brian" Ahn PhD, ARNP, ANP BC, College of Nursing, Department of Family, Community and Health System Science (2015-2017)
Scott Brakenridge, MD, College of Medicine, Department of Surgery (2015-2017)
Andrew Bryant, MD, College of Medicine, Department of Internal Medicine Pulmonary, Critical Care and Sleep Medicine (2015-2016)
Sara Burke, PhD, College of Medicine, Department of Neuroscience (2015-2017)
Huaihou Chen, PhD, Department of Biostatistics (2015-2017)
Sooyeon Lee, PhD, College of Medicine, Department of Surgery (2015-2016)
Joshua Brown, PhD, MS, Department of Pharmaceutical Outcomes & Policy (2017-2019)
Robert Mankowski, PhD, Department of Aging & Geriatric Research (2017-2019)
Yu-Jung “Jenny” Wei, PhD, MS , Department of Pharmaceutical Outcomes and Policy (2017-2019)
Dr. Joseph McQuail, PhD , Department of Neuroscience (2018-2019)
Dr. Terence Ryan, PhD, Department of Applied Physiology & Kinesiology (2018-2020)

PILOT/EXPLORATORY PROJECTS (5 Pilot Projects Listed)
1. Project Title: Time Course Adaptations using Deuterated Creatine (D3Cr) method
  Leader: Anoop Balachandran, PhD (Todd Manini, PhD)
 

This pilot study is focused on assessing the time course adaptions in functional muscle mass and performance outcomes in response to a high-intensity resistance training intervention in low functioning older adults.  It will provide critical clinical preliminary data for a successful extra-mural application for a future larger study. Specifically, the proposed future study will examine the impact of a high intensity resistance training intervention to increase skeletal muscle mass compared to an education control on physical performance outcomes, such as 400 m walk, lower body strength, balance, SPPB Short Physical Performance Battery (SPPB) in low functioning older adults.

 
2. Project Title: Circadian dysfunction in aging and chronic kidney disease
  Leader: Michelle Gumz, PhD (Karyn Esser, PhD)
 

The goal of this pilot study is to provide feasibility and supporting data for an R01 application. This new line of investigation is aimed at discerning mechanisms of and novel therapeutic interventions for chronic kidney disease. Chronic kidney disease is increasing in large part due to our aging population and it is associated with muscle wasting, decreased mobility, and increased disability. Our preliminary data for this pilot proposal strongly suggest that Dr. Esser’s unique mouse model of circadian disruption and accelerated aging has a renal defect. The funds requested in this application are necessary to test our hypothesis that circadian disruption and accelerated aging lead to kidney damage and reduced renal function. These funds are needed to provide supporting data for a larger, long-term project in which we will further test the hypothesis that circadian disruption and accelerated aging lead to chronic kidney disease with consequences for cardiovascular mortality.

 
3. Project Title: Exosomal Mediation of Exercise induced benefits in aging
  Leader: Brittney Yegla, PhD
 

The goal of this pilot study is to examine intercellular signaling, specifically exosomes and their miRNA content, in aging with exercised and non-exercised Fischer-344 rats. The study proposes to investigate age- and sex-related differences in exercise-induced exosome release following either an acute or sustained exercise regimen and how this relates to the changes in musculature, cognition, metabolism, inflammation, and redox state in multiple organs with exercise. Young and aged male and female rats will undergo treadmill running for a single bout of exercise (acute; Aim 1) or for two months on a progressive workload schedule (sustained; Aim 2) to produce a 70% VO2max. Following exercise rats will be evaluated for physical and cognitive capacity changes compared to sedentary controls. After   final bout of exercise, rats will be euthanized, and the blood, muscle, liver, kidney, brain, and fat tissue will be collected to examine the impact of age, sex, and exercise on exosome-derived miRNA expression and metabolic and inflammatory marker levels. Regular sustained exercise is expected to produce quantitative and qualitative changes in exosome-derived miRNA expression, correlating with cellular, cognitive, and physical changes. It is predicted that continued exercise will shift the aging secretome to resemble a younger profile. The findings from this study will not only establish the foundation for future NIH-funded experiments but also provide critical insight into age-related shifts in intercellular signaling and its sensitivity and responsiveness to exercise.

 
4. Project Title: Identification of novel circulating factors affecting skeletal muscle mass & function in advanced age
  Leader: Russell T. Hepple, PhD
 

This pilot study aims to identify novel circulating (blood-borne) factors that can promote physical function and maintenance of skeletal muscle mass and function in advanced age. We will capitalize on substantial pre-existing data, banked blood serum and banked myoblast cultures that we collected in recent studies examining world-class octogenarian track & field athletes as a model of very healthy aging. We will complement this with study of pre-frail/frail elderly individuals with the objective of identifying both positive circulating factors (e.g., those found in serum of world class octogenarian athletes) and negative circulating factors (e.g., those found in serum of pre-frail/frail elderly) by doing advanced proteomics screening of serum from these subjects. Additionally, we will conduct preliminary evaluation of promising candidate proteins enriched in high functioning (octogenarian athletes) versus low functioning (pre-frail/frail elderly) individuals by screening for muscle and neuromuscular junction impact using human myoblast cultures. These highly novel and exciting studies will directly address factors that likely contribute to mobility and disability with aging.

 
5. Project Title: Estrogen and Prevention of Hearing Loss
  Leader: Shinichi Someya, PhD
 

Numerous studies have reported gender differences in human auditory function. In general, the results of these studies show that women of virtually all ages demonstrate better hearing than men5-13. Considerable evidence also suggests that auditory function is diminished following menopause14-15, whereas estrogen therapy prevents decline of auditory function in postmenopausal women16-20. Estrogen also has neuroprotective and glutathione antioxidant defense actions21-24. However, the molecular mechanisms underlying these beneficial effects are largely unknown and prescribing estrogen therapy to women experiencing hearing problems remains controversial25-27. The central hypothesis of our research proposal is that estrogen protects hearing by enhancing glutathione transferase detoxification in the auditory system of females over the lifespan. The results of our proposed work will provide women, suffering from post-menopausal hearing loss, practical approaches to prevent decline of auditory function and disability associated with hearing loss.

 
DEVELOPMENT PROJECTS (1 Development Projects Listed)
1. Project Title: Development of Novel Measures to Assess Fuel Utilization and Circadian Rhythms in Overweight, Older Adults
  Leader: Stephen Anton, PhD, Karyn Esser, PhD, Christiaan Leeuwenburgh, PhD, Todd Manini, PhD, Marco Pahor, MD, Bhanuprasad Sandesara, MD, William Donahoo, MD, Peihua Qiu, PhD
  Core(s): Clinical Research Core (RC1)
Data Science and Applied Technology Core (RC 4) (Data Science)
Metabolism and Translational Science (RC2) (Metabolism and Translational Science)
 

The purpose of this development project is to develop and test the feasibility of relatively non-invasive new measures of fuel utilization and circadian health that can provide an index of both cellular and mitochondrial health. Hence, with this development project, we propose to investigate the feasibility of obtaining relatively non-invasive measures of fuel utilization and circadian health biomarkers in older adults. If these measures are found to be feasible, they may become useful measurement tools to be included in future clinical trials conducted within the University of Florida’s Pepper Center.

            In specific aim 1, we will test the feasibility of measuring fuel utilization within white blood cells through Seahorse XF Technology, a new measure that could detect shifts in fuel utilization at a cellular level. We will also measure 24-hour fluctuations in plasma glucose levels using a continuous glucose monitor.

            In specific aim 2, we will develop a new measure to detect the expression of circadian clock genes in whole blood. We will also test the feasibility of measuring systemic measure of circadian health using Wearable Technology (i.e., the Oura ring) that continuously tracks heart rate, body temperature, activity levels, as well as sleep patterns.

            The reliability and variability in the new measures of fuel utilization and circadian health markers will be compared to that of our standard Clinical Research Core measures of cognitive and physical function.  

 
RESEARCH (44 Projects Listed)
1. Project Title: Cardiac Dysfunction in Older Sepsis Survivors
  Leader(s): MANKOWSKI, ROBERT TOMASZ
    UNIVERSITY OF FLORIDA
    American Heart Association (AHA) 18CDA34080001 / (4192001-4451029)
  Core(s):
  As a result of sepsis, approximately 30% of older Americans (age >65 years) have elevated levels of systemic inflammation at discharge from the intensive care unit (ICU) and die from cardiovascular (CV) events, including congestive heart failure, within 12 months. Although recently improved implementation of evidence-based ICU care has resulted in decreased early hospital mortality in older adults...
 
2. Project Title: Calf Muscle Mitochondrial Dysfunction and Impaired Autophagy in Peripheral Artery Disease
  Leader(s): LEEUWENBURGH, CHRISTIAAN
    UNIVERSITY OF FLORIDA
    American Heart Association (AHA) 18SFRN33900136 / (4170475-4515845)
  Core(s):
  Lower-extremity peripheral artery disease (PAD) results in ischemia-reperfusion-induced oxidative stress in calf skeletal muscle and reduced skeletal muscle metabolic activity, but the specific mitochondrial defects and their association with functional impairment and decline in people with PAD are not established. In this basic-science research study of Northwestern Universitys Strategically Focu...
 
3. Project Title: Culturally sensitive, primary care clinic-based interventions by community health workers and trained physicians to promote and sustain weight loss among black women patients with obesity
  Leader(s): TUCKER, CAROLYN M
    UNIVERSITY OF FLORIDA
    PCORI AD-1609-36187 / (4105659-4537608)
  Core(s):
  Black women have the highest prevalence of obesity in the U.S. More than half (56.6%) of black women have obesity. This disease increases the likelihood of having diabetes and other chronic diseases, and decreases quality of life and life expectancy. The U.S. Preventive Services Task Force recommends that all adults who have obesity participate in an evidence-based, intensive, multicomponent behav...
 
4. Project Title: CEREBRAL NETWORKS OF LOCOMOTOR LEARNING AND RETENTION IN OLDER ADULTS
  Leader(s): CLARK, DAVID J
    VETERANS HEALTH ADMINISTRATION
    VA I01RX003115 / (4263914-4609284)
  Core(s):
  Aging often leads to substantial declines in walking function, especially for walking tasks that are more complex such as obstacle crossing. This is due in part to a lack of continued practice of complex walking (sedentary lifestyle) combined with age-related deficits of brain structure and the integrity of brain networks. Neurorehabilitation can contribute to recovery of lost walking function in ...
 
5. Project Title: PHARMACOLOGICAL MANAGEMENT OF PAIN IN ALZHEIMER'S DISEASE AND RELATED DEMENTIA
  Leader(s): WEI, YU-JUNG
    UNIVERSITY OF FLORIDA
    NIH K01AG054764 / (2017-2022)
  Core(s):
  Summary: My career goal is to become an independent geriatric pharmacoepidemiologist with expertise inpharmacotherapy quality measurement and outcomes evaluation in the fields of pain and aging. The clinicalfocus of my research has centered on the management of multi-morbidity in older adults and particularly, theinterplay of mental and physical disease and its treatment. One example of combinatio...
 
6. Project Title: INVESTIGATING MOVEMENT-EVOKED PAIN IN OSTEOARTHRITIC CONDITIONS (IMPACT): AN OBSERVATIONAL STUDY TO INFORM CULTURALLY-TAILORED INTERVENTION DEVELOPMENT
  Leader(s): BOOKER, STAJA
    UNIVERSITY OF FLORIDA
    NIH K23AR076463 / (2020-2023)
  Core(s):
  Knee osteoarthritis (OA) is one the most problematic sources of persistent musculoskeletal pain, impaired function and mobility, and reduced quality of life in older adults. Although these are common outcomes associated with OA, they are disproportionately worse in older African Americans. These threats to healthy aging demand further investigation into the most significant driver of OA pain and d...
 
7. Project Title: Natural language processing (NLP) to connect social determinants and clinical factors for outcomes research
  Leader(s): WU, YONGHUI
    UNIVERSITY OF FLORIDA
    PCORI ME-2018C3-14754 / (4328967-4674574)
  Core(s):
  People interact with the environment at different levels in a large social system. Individuals health outcomes are determined through a complex interplay of multilevel factors, including both social determinants of health (e.g., education, employment, social cohesion) and behavioral determinants of health (e.g., smoking). For example, cancer, the second leading cause of death in the U.S., presents...
 
8. Project Title: UNIVERSITY OF FLORIDA CLAUDE D. PEPPER OLDER AMERICANS INDEPENDENCE CENTER (OAIC)
  Leader(s): PAHOR, MARCO
    UNIVERSITY OF FLORIDA
    NIH P30AG028740 / (2007-2022)
  Core(s):
  PROJECT SUMMARYThe mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimizeolder persons' physical performance and mobility through interdisciplinary approaches; and 2) to train newinvestigators in aging and disability research while developing their leadership qualities. Our goal is to enhancelate-life health and independence, with a special focus...
 
9. Project Title: UNIVERSITY OF FLORIDA RESOURCE CENTER FOR MINORITY AGING RESEARCH
  Leader(s): FILLINGIM, ROGER B
    UNIVERSITY OF FLORIDA
    NIH P30AG059297 / (2018-2023)
  Core(s):
  PROJECT SUMMARYChronic pain conditions represent arguably the most prevalent and costly public health problem in the UnitedStates, and they are the leading cause of disability worldwide. While pain affects individuals throughout thelifespan, older adults are disproportionately impacted and are at particularly increased risk for chronic pain andpain-related disability. Surprisingly, knowledge regar...
 
10. Project Title: ADAPTABILITY AND RESILIENCE IN AGING ADULTS (ARIAA)
  Leader(s): BARTLEY, EMILY J.
    UNIVERSITY OF FLORIDA
    NIH R00AG052642 / (2016-2021)
  Core(s):
  Growing evidence supports the presence of dysregulated pain modulation in older adults, an effect which may heighten age-associated risk for chronic pain. While persistent pain is common in older adults, chronic low back pain is the leading cause of disability in this population and results in significant impairments in psychosocial and physical functioning. Given reports of suboptimal treatment o...
 
11. Project Title: ESTROGEN AND COGNITION OVER THE LIFESPAN
  Leader(s): FOSTER, THOMAS C; KUMAR, ASHOK ;
    UNIVERSITY OF FLORIDA
    NIH R01AG037984 / (2010-2023)
  Core(s):
  AbstractSex differences are evident in vulnerability to age-related cognitive decline and diseases of aging. Estradiol(E2) is protective against neurodegenerative diseases, including Alzheimer s disease, implicating sexhormone effects on sex differences in vulnerability. However, obstacles to sex steroid treatments includeclosing of the therapeutic window observed as decreased effectiveness of E2 ...
 
12. Project Title: HEALTH DISPARITIES IN OSTEOARTHRITIS: BIOLOGICAL AGING, STRESS, AND PAIN - MODULATION BY RESILIENCE FACTORS
  Leader(s): SIBILLE, KIMBERLY THERESA
    UNIVERSITY OF FLORIDA
    NIH R01AG054370 / (2016-2021)
  Core(s):
  Project Summary/AbstractOsteoarthritis (OA) is a prevalent and debilitating age-related health condition contributing toward physical andpsychosocial decline, reduced quality of life, and rising national expenses. Considerable evidencedemonstrates health disparities in the burdens of living with OA. Specifically, African Americans with knee OAexperience greater clinical pain, functional limitation...
 
13. Project Title: SENESCENCE AND GROWTH DIFFERENTIATION FACTORS AS MODIFIERS OF AGING
  Leader(s): LEBRASSEUR, NATHAN K
    MAYO CLINIC
    NIH R01AG055529 / (2018-2023)
  Core(s):
  PROJECT SUMMARY/ABSTRACTAging is the primary risk factor for the majority of chronic diseases. Studies in mice have implicated specificgrowth and differentiation factors (GDFs) and proteins secreted by senescent cells as potential modifiers ofaging. The objective of this proposal is to establish the rationale and provide robust clinical evidence for GDF8,GDF11, and senescence-related proteins eota...
 
14. Project Title: INTERMITTENT PNEUMATIC COMPRESSION FOR DISABILITY REVERSAL IN PAD: THE INTERCEDE TRIAL
  Leader(s): MCDERMOTT, MARY MCGRAE
    NORTHWESTERN UNIVERSITY AT CHICAGO
    NIH R01AG057693 / (2018-2023)
  Core(s):
  PROJECT SUMMARY Our work and that of others has established that people with lower extremity peripheral artery disease(PAD) have greater functional impairment and faster rates of functional decline than people without PAD.However, few therapies improve functioning or prevent functional decline in people with PAD. Intermittent pneumatic compression (IPC) is a non-invasive intervention, consisting o...
 
15. Project Title: MECHANISMS OF OXYTOCINS ANALGESIA IN OLDER ADULTS
  Leader(s): CRUZ-ALMEIDA, YENISEL; EBNER, NATALIE C ;
    UNIVERSITY OF FLORIDA
    NIH R01AG059809 / (2018-2023)
  Core(s):
  ABSTRACTOsteoarthritis (OA) represents a significant cause of disability worldwide in individuals aged 65 and older, arapidly growing segment of our population. The knee is the most commonly affected joint with pain being theprimary symptom, negatively impacting physical, cognitive, and emotional functioning. Symptomatic knee OAhas been traditionally attributed to peripheral mechanisms, but measur...
 
16. Project Title: ACTIVE ROLES OF GLIAL CELLS IN OLFACTION AND AGE-RELATED OLFACTORY DECLINE
  Leader(s): XIAO, RUI
    UNIVERSITY OF FLORIDA
    NIH R01AG063766 / (2019-2024)
  Core(s):
  Project SummaryAge-dependent olfactory decline (presbyosmia) is widely present in many species, including humans. At leastfifteen million Americans over 55 years old suffer from presbyosmia. By affecting the well-being, quality of life,and overall health, presbyosmia presents a significant challenge to public health. Patients with presbyosmiaoften show a decreased interest in food, can withdraw so...
 
17. Project Title: BIOBEHAVIORAL BASIS OF KNEE OSTEOARTHRITIS PAIN
  Leader(s): CRUZ-ALMEIDA, YENISEL
    UNIVERSITY OF FLORIDA
    NIH R01AG067757 / (2020-2025)
  Core(s):
  Discovery and validation of strong candidate biomarkers and clinical endpoints for pain is urgently needed that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials. Emerging research using a combination of biomarkers deliver individualized predictions about future brain and body health. Our own findings suggest that behavioral c...
 
18. Project Title: THE EFFECT OF INTERMITTENT HEMIDIAPHRAGM STIMULATION DURING SURGERY ON MITOCHONDRIAL FUNCTION, SINGLE FIBER CONTRACTILE FORCE AND CATABOLIC PATHWAYS IN HUMANS
  Leader(s): SMITH, BARBARA K; BEAVER, THOMAS M ;
    UNIVERSITY OF FLORIDA
    NIH R01AR072328 / (2017-2021)
  Core(s):
  Although mechanical ventilation (MV) is life-sustaining in patients with respiratory failure, it comes with a cost.MV dramatically reduces diaphragm contractility, induces ventilator-induced diaphragm dysfunction (VIDD) andsometimes leads to weaning failure. VIDD includes reduced mitochondrial respiration and increased oxidativestress, muscle fiber damage and decreased diaphragm force production. ...
 
19. Project Title: THE BENEFITS AND HARMS OF LUNG CANCER SCREENING IN FLORIDA
  Leader(s): BIAN, JIANG; GUO, YI ;
    UNIVERSITY OF FLORIDA
    NIH R01CA246418 / (2020-2023)
  Core(s):
  Lung cancer is the leading cause of cancer related death in both men and women in the United States. Currently, approximately 70% of lung cancer patients are diagnosed at advanced stages, and the 5-year survival rate of advanced stage lung cancer is very low, at only 16%. Investigators have been searching for effective screening modalities for the early detection of lung cancer so that patients ca...
 
20. Project Title: Evaluation of an Adaptive Intervention for Weight Loss Maintenance
  Leader(s): ROSS, KATHRYN MARIE
    UNIVERSITY OF FLORIDA
    NIH R01DK119244 / (4278344-4688767)
  Core(s):
  Obesity remains a substantial public health challenge in the United States. Behavioral weight management programs have demonstrated effectiveness for weight loss, but long-term maintenance of these weight losses after the end of treatment tends to be poor. Evidence has demonstrated that individuals who can maintain their changes in eating and activity can successfully maintain their weight loss; t...
 
21. Project Title: EVALUATION OF AN ADAPTIVE INTERVENTION FOR WEIGHT LOSS MAINTENANCE
  Leader(s): ROSS, MATHRYN MARIE
    UNIVERSITY OF FLORIDA
    NIH R01DK119244 / (4278344-4688767)
  Core(s):
  Obesity remains a substantial public health challenge in the United States. Behavioral weight management programs have demonstrated effectiveness for weight loss, but long-term maintenance of these weight losses after the end of treatment tends to be poor. Evidence has demonstrated that individuals who can maintain their changes in eating and activity can successfully maintain their weight loss; t...
 
22. Project Title: THE ROLE AND MECHANISMS OF LIPID AND LIPOPROTEIN DYSREGULATION IN SEPSIS
  Leader(s): GUIRGIS, FAHEEM W
    UNIVERSITY OF FLORIDA
    NIH R01GM133815 / (2020-2025)
  Core(s):
  Sepsis is a dysregulated response to infection that has both fatal and non-fatal morbid consequences. Unfortunately, initial survival does not provide relief from morbidity for most sepsis survivors. Initial clinical trajectories include rapid recovery, early in-hospital death, and progression to chronic critical illness (ICU stay = 14 days with organ dysfunction). Late complications include sepsi...
 
23. Project Title: IMPROVE PAD PERFORMANCE WITH METFORMIN. THE PERMET TRIAL
  Leader(s): MCDERMOTT, MARY MCGRAE
    NORTHWESTERN UNIVERSITY AT CHICAGO
    NIH R01HL131771 / (2016-2021)
  Core(s):
  PROJECT SUMMARY Improve PAD PERformance with METformin: The PERMET Trial. Our work and that of others has established that people with lower extremity peripheral artery disease(PAD) have greater functional impairment, faster functional decline, and increased rates of mobility losscompared to people without PAD. However, few therapies are available that improve functioning or preventfunctional decl...
 
24. Project Title: TRANSCRIPTIONAL REGULATION OF KCNH2
  Leader(s): DELISLE, BRIAN P
    UNIVERSITY OF KENTUCKY
    NIH R01HL141343 / (2019-2023)
  Core(s):
  SummaryCircadian rhythms help to match the optimal function of the cardiovascular system to the daily changes in theenvironment. Normal cardiovascular rhythms provide a physiological advantage to people. Unfortunately,normal circadian signaling can also unmask a time-of-day pattern in adverse events like heart attack, stroke,and sudden death in patients with underlying cardiovascular disease.Emerg...
 
25. Project Title: IMPAIRED MITOCHONDRIAL ENERGETICS IS A DRIVER OF HEMODIALYSIS ACCESS RELATED HAND DYSFUNCTION
  Leader(s): SCALI, SALVATORE T.
    UNIVERSITY OF FLORIDA
    NIH R01HL148597 / (2019-2024)
  Core(s):
  PROJECT SUMMARYCurrently, in the United States, there are ~425,000 patients receiving hemodialysis (HD) and it is estimated that30-60% of this population have some element of hand dysfunction after hemoaccess surgery. The underlyingpathophysiologic mechanisms responsible for this devastating problem are poorly understood. The renaldysfunction (RD) milieu causes a variety of physiologic derangement...
 
26. Project Title: MOLECULAR MECHANISMS REGULATING PERIPHERAL ARTERIAL DISEASE PATHOBIOLOGY IN CHRONIC KIDNEY DISEASE
  Leader(s): RYAN, TERENCE E
    UNIVERSITY OF FLORIDA
    NIH R01HL149704 / (2019-2024)
  Core(s):
  Peripheral artery disease (PAD) is caused by atherosclerosis in the lower extremities which leads to a spectrum of life-altering symptomatology, including claudication, ischemic rest pain, and gangrene requiring limb amputation. Complicating the etiology of PAD, patients typically present with comorbid conditions or risk factors that accelerate disease evolution and substantially worsen pathology ...
 
27. Project Title: CIRCADIAN CLOCK REGULATION OF MYOCARDIAL ION CHANNEL EXPRESSION AND FUNCTION
  Leader(s): ESSER, KARYN A; DELISLE, BRIAN P ;
    UNIVERSITY OF FLORIDA
    NIH R01HL153042 / (2020-2024)
  Core(s):
  The overall objectives of this proposal are to 1) define the genomic and transcriptomic mechanisms by which the cardiomyocyte clock regulates ion channels that contribute to cardiac excitability; and 2) disrupt the cardiomyocyte clock to link changes in circadian-ordered gene expression with electrophysiological properties of atrial and ventricular cardiomyocytes. The outcomes will address signifi...
 
28. Project Title: EMOTIONAL ENGAGEMENT DRIVEN BY COMPLEX VISUAL STIMULI: NEURAL DYNAMICS REVEALED BY MULTIMODAL IMAGING
  Leader(s): DING, MINGZHOU; KEIL, ANDREAS ;
    UNIVERSITY OF FLORIDA
    NIH R01MH112558 / (2017-2022)
  Core(s):
  Project Summary Emotional dysfunction is at the core of many psychiatric disorders, in particular fear, anxiety, post- traumatic, and mood disorders. Describing the neural mechanisms associated with emotional processing is therefore a critical issue in mental health care. Previous attempts to define the neurophysiology of human emotions in the cognitive neuroscience laboratory have been hamp...
 
29. Project Title: BIOBEHAVIORAL MECHANISMS UNDERLYING SYMPTOMS AND HEALING OUTCOMES IN OLDER INDIVIDUALS WITH CVLU
  Leader(s): STECHMILLER, JOYCE K.; LYON, DEBRA E ;
    UNIVERSITY OF FLORIDA
    NIH R01NR016986 / (2018-2023)
  Core(s):
  ABSTRACT Our long-term goal is to elucidate the complex biobehavioral mechanisms responsible for symptoms andhealing outcomes for older adults with venous leg ulcers (VLUs) for the development of targeted therapies thataddress both the patient-oriented outcomes and healing outcomes in this growing group of affected individuals.VLUs, which account for 70 90% of ulcers found in the lower leg, affec...
 
30. Project Title: OPTIMIZING AAV VECTORS FOR CENTRAL NERVOUS SYSTEM TRANSDUCTION
  Leader(s): HELDERMON, COY D
    UNIVERSITY OF FLORIDA
    NIH R01NS102624 / (2017-2022)
  Core(s):
  Project SummaryMucopolysaccharidosis (MPS) IIIB is a neurodegenerative lysosomal storage disease (LSD) caused by deficientdegradation of heparan sulfate. Clinically this manifests as cognitive decline, developmental regression, impairedmobility and ultimately premature death. There are currently no effective therapies. Due to the neurodegenerativenature of this disease, optimal CNS transduction is...
 
31. Project Title: WEARABLE TECHNOLOGY INFRASTRUCTURE TO ENHANCE CAPACITY FOR REAL-TIME, ONLINE ASSESSMENT AND MOBILITY (ROAMM) OF INTERVENING HEALTH EVENTS IN OLDER ADULTS
  Leader(s): MANINI, TODD; RANKA, SANJAY ;
    UNIVERSITY OF FLORIDA
    NIH R21AG059207 / (2019-2021)
  Core(s):
  ABSTRACTOlder Americans experience approximately 29 million falls and 13 million hospitalizations per year. Theseintervening health events (IHE - episodic falls, injuries, illnesses, and hospitalizations) are strong precipitants ofdisability in older adults. Because of their episodic nature, IHEs are extremely difficult to study. Continuous,long-term monitoring with remote capabilities using weara...
 
32. Project Title: SYSTEMATIC ANALYSIS OF CLINICAL STUDY GENERALIZABILITY ASSESSMENT METHODS WITH INFORMATICS
  Leader(s): HE, ZHE; BIAN, JIANG ;
    FLORIDA STATE UNIVERSITY
    NIH R21AG061431 / (2019-2021)
  Core(s):
  Clinical studies are often conducted under idealized and rigorously controlled conditions to improve their internal validity and success rates, but compromise their external validity (i.e., generalizability to the target populations). These idealized conditions are sometimes exaggerated and reflected as overly restrictive eligibility criteria. Certain population subgroups are often excluded with u...
 
33. Project Title: ADVANCING INTERDISCIPLINARY SCIENCE OF AGING THROUGH IDENTIFICATION OF IATROGENIC COMPLICATIONS: THE UF EHR CLINICAL DATA INFRASTRUCTURE FOR ENHANCED PATIENT SAFETY AMONG THE ELDERLY (UF-ECLIPSE)
  Leader(s): INGIBJARGARDOTTIR BJARNADOTTIR, RAGNHILDUR; LUCERO, ROBERT J ;
    UNIVERSITY OF FLORIDA
    NIH R21AG062884 / (2019-2021)
  Core(s):
  Iatrogenic conditions are a continuing public health concern, causing death among an estimated two hundred and fifty thousand older adults annually in United States (US) hospitals. Hospital-acquired falls and hospital- induced delirium are among the most common and costly iatrogenic conditions, and their occurrences are linked to each other. Advances in computing technology and availability of ele...
 
34. Project Title: NICOTINAMIDE RIBOSIDE AS AN ENHANCER OF EXERCISE THERAPY IN HYPERTENSIVE OLDER ADULTS: THE NEET TRIAL
  Leader(s): MANKOWSKI, ROBERT
    UNIVERSITY OF FLORIDA
    NIH R21AG064282 / (2019-2021)
  Core(s): - Research Education Component (REC)
- Clinical Research Core (RC1)
- Biostatistics Core (RC 3) (Biostats)
- Metabolism and Translational Science (RC2) (Metabolism and Translational Science)
  ABSTRACTMore than 80% of older adults have hypertension, with higher prevalence of high systolic blood pressure (SBP)putting them at high risk for cardiovascular (CV) disease and death. Because drug therapy that lowers SBP isassociated with side effects such as hypotension, syncope, and kidney dysfunction, there is a great need foreffective lifestyle SBP-lowering interventions for the older popula...
 
35. Project Title: THE UNIVERSITY OF FLORIDA JACKSONVILLE AGING STUDIES CENTER (JAX-ASCENT)
  Leader(s): PAHOR, MARCO; ANTON, STEPHEN D ;
    UNIVERSITY OF FLORIDA
    NIH R33AG056540 / (2017-2022)
  Core(s):
  SummaryOlder adults of racial minorities and low socioeconomic (SES) status represent particularly high riskpopulations who are underserved and are significantly underrepresented in clinical research. This has led to agap in knowledge regarding the appropriate and/or optimal prevention and treatment approaches for this highrisk group. Within the state of Florida, the city of Jacksonville (JAX) has...
 
36. Project Title: ETHNIC DIFFERENCES IN RESPONSES TO PAINFUL STIMULI
  Leader(s): FILLINGIM, ROGER B
    UNIVERSITY OF FLORIDA
    NIH R37AG033906 / (2009-2024)
  Core(s):
  No abstract provided...
 
37. Project Title: THE INTEGRATIVE AND MULTIDISCIPLINARY PAIN AND AGING RESEARCH TRAINING (IMPART) PROGRAM
  Leader(s): FILLINGIM, ROGER B
    UNIVERSITY OF FLORIDA
    NIH T32AG049673 / (2015-2025)
  Core(s):
  DESCRIPTION (provided by applicant): As detailed in a recent Institute of Medicine (IOM) report, chronic pain represents a major public health concern, affecting 100 million U.S. adults and costing more than $500 billion annually. Aging confers increased risk for chronic pain, with half of older adults reporting persistent or recurring pain, and aging is associated with greater pain-rel...
 
38. Project Title: TRANSLATIONAL RESEARCH TRAINING ON AGING AND MOBILITY (TRAM)
  Leader(s): MANINI, TODD
    UNIVERSITY OF FLORIDA
    NIH T32AG062728 / (2020-2025)
  Core(s):
  Preserved mobility is one of hallmarks of geriatric care, gerontology and geroscience. The loss of mobility with aging is progressive, caused by multiple factors and does not have a simple cure. Unfortunately, mobility loss continues to lack clinical attention, robust biomedical targets, objectively-measured surveillance systems, and effective treatments. As a result, mobility difficulties have re...
 
39. Project Title: MOLECULAR BIOLOGY IN BURNS AND TRAUMA
  Leader(s): MOLDAWER, LYLE L
    UNIVERSITY OF FLORIDA
    NIH T32GM008721 / (1999-2024)
  Core(s):
  This Ruth Kirschstein NRSA training Program proposes to take primarily surgeons and other critical caremedicine physicians during the second or third year of their general residency programs, and expose them totwo, three and even four years of mentored research in inflammation biology with highly productive basic sciencementors focused on inflammation-related topics. Four training positions are re...
 
40. Project Title: UF PASS: REGULATION OF EXERCISE TRANSDUCERS
  Leader(s): ESSER, KARYN A
    UNIVERSITY OF FLORIDA
    NIH U01AG055137 / (2016-2022)
  Core(s):
  Abstract Exercise is a powerful and pleiotropic physiological stimulus that helps prevent many chronicdiseases and is used as a therapeutic for disease. While the beneficial effects of exercise are extensivelyacknowledged there is still very little understood about the molecular transducers of the systems-wide effects.The goal of this University of Florida Molecular Transducers of Physical Activit...
 
41. Project Title: MULTIMODAL IMAGING OF BRAIN ACTIVITY TO INVESTIGATE WALKING AND MOBILITY DECLINE IN OLDER ADULTS
  Leader(s): MANINI, TODD; CLARK, DAVID J. ; SEIDLER, RACHAEL D ;
    UNIVERSITY OF FLORIDA
    NIH U01AG061389 / (2018-2023)
  Core(s):
  Project Description: Mobility impairments in older adults decrease quality of life and are associated with highsocietal and economic burden. NIH RFA-AG-18-019 solicits applications to investigate the central neuralcontrol of mobility in older adults using innovative and cutting-edge methods. Current approaches to studythe neural control of walking are limited by either the inability to measure ...
 
42. Project Title: PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
  Leader(s): ALEXANDER, KAREN; AMBROSIUS, WALTER T; HERNANDEZ, ADRIAN; WILLIAMSON, JEFF DOUGLAS
    DUKE UNIVERSITY
    NIH U19AG065188 / (4299870-4983988)
  Core(s):
  There is an urgent need for evidence to guide clinical care of older adults due to demographic shifts, including longer life expectancy and a recent doubling of the older adult population. Statins reduce recurrent CVD events and prevent initial events in patients younger than 75 years. However, clinical research has often excluded persons older than 75 years due to a higher prevalence of comorbidi...
 
43. Project Title: MOTRPAC CONSORTIUM COORDINATING CENTER
  Leader(s): PAHOR, MARCO; MILLER, MICHAEL E. ; REJESKI, WALTER JOHN ; TRACY, RUSSELL P ;
    UNIVERSITY OF FLORIDA
    NIH U24AR071113 / (2016-2022)
  Core(s):
  SummaryPhysical inactivity is a major public health challenge underlying a broad range of health problems at all ages.While physical activity (PA) has shown to produce relevant health benefits, the underlying molecularmechanisms are poorly known. The coordinated effort of clinical and animal studies supported bybioinformatics and chemical analyses will achieve the Molecular Transducers of Physical...
 
44. Project Title: TOGETHER: TRANSFORMING AND TRANSLATING DISCOVERY TO IMPROVE HEALTH
  Leader(s): MITCHELL, DUANE A.
    UNIVERSITY OF FLORIDA
    NIH UL1TR001427 / (2015-2024)
  Core(s):
  Florida is a demographically and geographically diverse state. The University of Florida (UF) and Florida StateUniversity (FSU) CTSA hub will work within this environment to further the mission to improve human health byaccelerating the translation of scientific discoveries and the implementation of evidence-based best practicesfor the diagnosis, treatment, prevention and cure of human diseases ac...
 
PUBLICATIONS
2021
  1. Cannabidiol as prophylaxis for SARS-CoV-2 and COVID-19? Unfounded claims versus potential risks of medications during the pandemic.
    Brown JD
    Res Social Adm Pharm, 2021 Jan, 17(1): 2053
    https://doi.org/10.1016/j.sapharm.2020.03.020 | PMID: 32273254 | PMCID: PMC7269703
    Citations: 9 | AltScore: 13.75
  2. Three-Year, Postintervention, Follow-up Comparison of Health Care Resource Utilization and Costs in the Lifestyle Interventions and Independence for Elders (LIFE) Study.
    Brown JD, Wang CY, Groessl EJ, Pahor M, Manini TM
    J Gerontol A Biol Sci Med Sci, 2021 Jan 18, 76(2): 272-276
    https://doi.org/10.1093/gerona/glaa088 | PMID: 32270182 | PMCID: PMC7812479
    Citations: 1 | AltScore: 3.35
  3. Preliminary investigation of interactive associations of sleep and pain with cognition in sedentary middle-aged and older adults.
    Curtis AF, Dzierzewski JM, Buman MP, Giacobbi PR, Roberts BL, Aiken-Morgan AT, Marsiske M, McCrae CS
    J Clin Sleep Med, 2021 Feb 1, 17(2): 233-242
    https://doi.org/10.5664/jcsm.8856 | PMID: 33006311 | PMCID: PMC7853205
    Citations: | AltScore: 6.3
  4. The Effect of Sensor Placement and Number on Physical Activity Recognition and Energy Expenditure Estimation in Older Adults: Validation Study.
    Davoudi A, Mardini MT, Nelson D, Albinali F, Ranka S, Rashidi P, Manini TM
    JMIR Mhealth Uhealth, 2021 May 3, 9(5): e23681
    https://doi.org/10.2196/23681 | PMID: 33938809 | PMCID: PMC8129874
    Citations: | AltScore: NA
  5. A Role for Exercise to Counter Skeletal Muscle Clock Disruption.
    Erickson ML, Esser KA, Kraus WE, Buford TW, Redman LM
    Exerc Sport Sci Rev, 2021 Jan, 49(1): 35-41
    https://doi.org/10.1249/JES.0000000000000235 | PMID: 33044328 | PMCID: PMC7773215
    Citations: | AltScore: 68
  6. Age and intranasal oxytocin effects on trust-related decisions after breach of trust: Behavioral and brain evidence.
    Frazier I, Lin T, Liu P, Skarsten S, Feifel D, Ebner NC
    Psychol Aging, 2021 Feb, 36(1): 10-21
    https://doi.org/10.1037/pag0000545 | PMID: 33705182 | PMCID: PMC8202094
    Citations: | AltScore: 0.5
  7. Elevated lymphotoxin-a (TNF?) is associated with intervertebral disc degeneration.
    Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
    BMC Musculoskelet Disord, 2021 Jan 13, 22(1): 77
    https://doi.org/10.1186/s12891-020-03934-7 | PMID: 33441130 | PMCID: PMC7807514
    Citations: | AltScore: NA
  8. Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.
    Harper SA, Bassler JR, Peramsetty S, Yang Y, Roberts LM, Drummer D, Mankowski RT, Leeuwenburgh C, Ricart K, Patel RP, Bamman MM, Anton SD, Jaeger BC, Buford TW
    Exp Gerontol, 2021 Jan, 143: 111111
    https://doi.org/10.1016/j.exger.2020.111111 | PMID: 33068691 | PMCID: PMC7855904
    Citations: | AltScore: 150.55
  9. An external exposome-wide association study of COVID-19 mortality in the United States.
    Hu H, Zheng Y, Wen X, Smith SS, Nizomov J, Fishe J, Hogan WR, Shenkman EA, Bian J
    Sci Total Environ, 2021 May 10, 768: 144832
    https://doi.org/10.1016/j.scitotenv.2020.144832 | PMID: 33450687 | PMCID: PMC7788319
    Citations: 2 | AltScore: 3.25
  10. Vascular dysfunction as a potential culprit of sarcopenia.
    Jeon YK, Shin MJ, Saini SK, Custodero C, Aggarwal M, Anton SD, Leeuwenburgh C, Mankowski RT
    Exp Gerontol, 2021 Mar, 145: 111220
    https://doi.org/10.1016/j.exger.2020.111220 | PMID: 33373710 | PMCID: PMC8168450
    Citations: | AltScore: 11.65
  11. Multi-ethnic GWAS and meta-analysis of sleep quality identify MPP6 as a novel gene that functions in sleep center neurons.
    Khoury S, Wang QP, Parisien M, Gris P, Bortsov AV, Linnstaedt SD, McLean SA, Tungate AS, Sofer T, Lee J, Louie T, Redline S, Kaunisto MA, Kalso EA, Munter HM, Nackley AG, Slade GD, Smith SB, Zaykin DV, Fillingim RB, Ohrbach R, Greenspan JD, Maixner W, Neely GG, Diatchenko L
    Sleep, 2021 Mar 12, 44(3):
    pii: zsaa211. https://doi.org/10.1093/sleep/zsaa211 | PMID: 33034629 | PMCID: PMC7953222
    Citations: | AltScore: 4.75
  12. Older adults demonstrate biomarker evidence of the persistent inflammation, immunosuppression and catabolism syndrome (PICS) after sepsis.
    Mankowski RT, Anton SD, Ghita GL, Brumback B, Darden DB, Bihorac A, Moldawer LL, Efron PA, Brakenridge SC, Moore FA
    J Gerontol A Biol Sci Med Sci, 2021 Mar 15
    pii: glab080. https://doi.org/10.1093/gerona/glab080 | PMID: 33721883
    Citations: 1 | AltScore: 5.45
  13. Age Differences in Estimating Physical Activity by Wrist Accelerometry Using Machine Learning.
    Mardini MT, Bai C, Wanigatunga AA, Saldana S, Casanova R, Manini TM
    Sensors (Basel), 2021 May 12, 21(10):
    pii: 3352. https://doi.org/10.3390/s21103352 | PMID: 34065906 | PMCID: PMC8150764
    Citations: | AltScore: NA
  14. The Temporal Relationship Between Ecological Pain and Life-Space Mobility in Older Adults With Knee Osteoarthritis: A Smartwatch-Based Demonstration Study.
    Mardini MT, Nerella S, Kheirkhahan M, Ranka S, Fillingim RB, Hu Y, Corbett DB, Cenko E, Weber E, Rashidi P, Manini TM
    JMIR Mhealth Uhealth, 2021 Jan 13, 9(1): e19609
    https://doi.org/10.2196/19609 | PMID: 33439135 | PMCID: PMC7840291
    Citations: | AltScore: NA
  15. Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.
    McQuail JA, Dunn AR, Stern Y, Barnes CA, Kempermann G, Rapp PR, Kaczorowski CC, Foster TC
    Front Aging Neurosci, 2020, 12: 607685
    https://doi.org/10.3389/fnagi.2020.607685 | PMID: 33551788 | PMCID: PMC7859530
    Citations: | AltScore: 15.15
  16. Sesquiterpene Alcohol Cedrol Chemosensitizes Human Cancer Cells and Suppresses Cell Proliferation by Destabilizing Plasma Membrane Lipid Rafts.
    Mishra SK, Bae YS, Lee YM, Kim JS, Oh SH, Kim HM
    Front Cell Dev Biol, 2020, 8: 571676
    https://doi.org/10.3389/fcell.2020.571676 | PMID: 33585438 | PMCID: PMC7874189
    Citations: | AltScore: 0.5
  17. Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.
    Morris EJ, Brown JD, Manini TM, Vouri SM
    Drugs Aging, 2021 Jun 7
    https://doi.org/10.1007/s40266-021-00868-0 | PMID: 34095980
    Citations: | AltScore: 3.85
  18. Safety and tolerability of chronic intranasal oxytocin in older men: results from a randomized controlled trial.
    Rung JM, Horta M, Tammi EM, Perez E, Ojeda MC, Lin T, Harris G, Somerville J, Salmeron D, Beltz SE, Sandesara B, Feifel D, Ebner NC
    Psychopharmacology (Berl), 2021 May 12
    https://doi.org/10.1007/s00213-021-05862-3 | PMID: 33982141 | PMCID: PMC8115997
    Citations: | AltScore: 0.5
  19. Exercise mitigates sleep-loss-induced changes in glucose tolerance, mitochondrial function, sarcoplasmic protein synthesis, and diurnal rhythms.
    Saner NJ, Lee MJ, Kuang J, Pitchford NW, Roach GD, Garnham A, Genders AJ, Stokes T, Schroder EA, Huo Z, Esser KA, Phillips SM, Bishop DJ, Bartlett JD
    Mol Metab, 2021 Jan, 43: 101110
    https://doi.org/10.1016/j.molmet.2020.101110 | PMID: 33137489 | PMCID: PMC7704425
    Citations: 1 | AltScore: 190.15
  20. Safety signals for QT prolongation or Torsades de Pointes associated with azithromycin with or without chloroquine or hydroxychloroquine.
    Sarayani A, Cicali B, Henriksen CH, Brown JD
    Res Social Adm Pharm, 2021 Feb, 17(2): 483-486
    https://doi.org/10.1016/j.sapharm.2020.04.016 | PMID: 32327397 | PMCID: PMC7166303
    Citations: 22 | AltScore: 26.55
  21. A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response.
    Sheng Y, Yang G, Casey K, Curry S, Oliver M, Han SM, Leeuwenburgh C, Xiao R
    Geroscience, 2021 Feb 1, 43(2): 691-707
    https://doi.org/10.1007/s11357-021-00327-z | PMID: 33527323 | PMCID: PMC8110660
    Citations: | AltScore: 0.75
  22. Distinct temporal actions of different types of unfolded protein responses during aging.
    Sheng Y, Yang G, Markovich Z, Han SM, Xiao R
    J Cell Physiol, 2021 Jul, 236(7): 5069-5079
    https://doi.org/10.1002/jcp.30215 | PMID: 33345326 | PMCID: PMC8026671
    Citations: | AltScore: 6.25
  23. An evaluation of co-use of chloroquine or hydroxychloroquine plus azithromycin on cardiac outcomes: A pharmacoepidemiological study to inform use during the COVID19 pandemic.
    Vouri SM, Thai TN, Winterstein AG
    Res Social Adm Pharm, 2021 Jan, 17(1): 2012-2017
    https://doi.org/10.1016/j.sapharm.2020.04.031 | PMID: 32409150 | PMCID: PMC7190482
    Citations: 9 | AltScore: 112.8
  24. Temperature Sensation: From Molecular Thermosensors to Neural Circuits and Coding Principles.
    Xiao R, Xu XZS
    Annu Rev Physiol, 2021 Feb 10, 83: 205-230
    https://doi.org/10.1146/annurev-physiol-031220-095215 | PMID: 33085927 | PMCID: PMC7932759
    Citations: 1 | AltScore: 3.75
  25. Partial microglial depletion is associated with impaired hippocampal synaptic and cognitive function in young and aged rats.
    Yegla B, Boles J, Kumar A, Foster TC
    Glia, 2021 Jun, 69(6): 1494-1514
    https://doi.org/10.1002/glia.23975 | PMID: 33586813
    Citations: 1 | AltScore: 1
 
2020
  1. AAAPT Diagnostic Criteria for Acute Knee Arthroplasty Pain.
    Abdallah FW, Gilron I, Fillingim RB, Tighe P, Parvataneni HK, Ghasemlou N, Sawhney M, McCartney CJL
    Pain Med, 2020 May 1, 21(5): 1049-1060
    https://doi.org/10.1093/pm/pnz355 | PMID: 32022891
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  2. A Novel Approach to Characterizing Readmission Patterns Following Hospitalization for Ambulatory Care-Sensitive Conditions.
    Agana DFG, Striley CW, Cook RL, Cruz-Almeida Y, Carek PJ, Salemi JL
    J Gen Intern Med, 2020 Apr, 35(4): 1060-1068
    https://doi.org/10.1007/s11606-020-05643-2 | PMID: 31993948 | PMCID: PMC7174498
    Citations: 2 | AltScore: 0.25
  3. Feasibility and efficacy of remotely supervised cranial electrical stimulation for pain in older adults with knee osteoarthritis: A randomized controlled pilot study.
    Ahn H, Galle K, Mathis KB, Miao H, Montero-Hernandez S, Jackson N, Ju HH, McCrackin H, Goodwin C, Hargraves A, Jain B, Dinh H, Abdul-Mooti S, Park L, Pollonini L
    J Clin Neurosci, 2020 Jul, 77: 128-133
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  4. A Simulated Graphical Interface for Integrating Patient-Generated Health Data From Smartwatches With Electronic Health Records: Usability Study.
    Alpert JM, Kota NSP, Ranka S, Mendoza TV, Solberg LM, Rashidi P, Manini TM
    JMIR Hum Factors, 2020 Oct 30, 7(4): e19769
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  5. Secondary care provider attitudes towards patient generated health data from smartwatches.
    Alpert JM, Manini T, Roberts M, Kota NSP, Mendoza TV, Solberg LM, Rashidi P
    NPJ Digit Med, 2020, 3: 27
    https://doi.org/10.1038/s41746-020-0236-4 | PMID: 32140569 | PMCID: PMC7054258
    Citations: 3 | AltScore: 6.8
  6. Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging.
    Anagnostou ME, Hepple RT
    Cells, 2020 Jan 13, 9(1):
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    Citations: 6 | AltScore: 12.4
  7. Innovations in Geroscience to enhance mobility in older adults.
    Anton SD, Cruz-Almeida Y, Singh A, Alpert J, Bensadon B, Cabrera M, Clark DJ, Ebner NC, Esser KA, Fillingim RB, Goicolea SM, Han SM, Kallas H, Johnson A, Leeuwenburgh C, Liu AC, Manini TM, Marsiske M, Moore F, Qiu P, Mankowski RT, Mardini M, McLaren C, Ranka S, Rashidi P, Saini S, Sibille KT, Someya S, Wohlgemuth S, Tucker C, Xiao R, Pahor M
    Exp Gerontol, 2020 Dec, 142: 111123
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  8. Impact of Injury Severity on the Inflammatory State and Severe Anemia.
    Apple CG, Miller ES, Loftus TJ, Kannan KB, Parvataneni HK, Hagen JE, Efron PA, Mohr AM
    J Surg Res, 2020 Apr, 248: 109-116
    https://doi.org/10.1016/j.jss.2019.10.046 | PMID: 31881381 | PMCID: PMC7054167
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  9. Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
    Balachandran A, Gundermann DM, Walkup MP, King AC, Ambrosius WT, Kritchevsky SB, Pahor M, Newman AB, Manini TM
    Med Sci Sports Exerc, 2020 Apr, 52(4): 859-867
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  10. Discovery and Validation of Urinary Molecular Signature of Early Sepsis.
    Bandyopadhyay S, Lysak N, Adhikari L, Velez LM, Sautina L, Mohandas R, Lopez MC, Ungaro R, Peng YC, Kadri F, Efron P, Brakenridge S, Moldawer L, Moore F, Baker HV, Segal MS, Ozrazgat-Baslanti T, Rashidi P, Bihorac A
    Crit Care Explor, 2020 Oct, 2(10): e0195
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  11. American Heart Association Vascular Disease Strategically Focused Research Network.
    Barnett JV, Beckman JA, Bonaca MP, Carnethon MR, Cassis LA, Creager MA, Daugherty A, Feinberg MW, Freiberg MS, Goodney PP, Greenland P, Leeuwenburgh C, LeMaire SA, McDermott MM, Sabatine MS, Shen YH, Wasserman DH, Webb NR, Wells QS
    Arterioscler Thromb Vasc Biol, 2020 Mar, 40(3): e47-e54
    https://doi.org/10.1161/ATVBAHA.120.313967 | PMID: 31969016 | PMCID: PMC7047580
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  12. Assessing the practice of data quality evaluation in a national clinical data research network through a systematic scoping review in the era of real-world data.
    Bian J, Lyu T, Loiacono A, Viramontes TM, Lipori G, Guo Y, Wu Y, Prosperi M, George TJ, Harle CA, Shenkman EA, Hogan W
    J Am Med Inform Assoc, 2020 Dec 9, 27(12): 1999-2010
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  13. Psychological Predictors of Perceived Age and Chronic Pain Impact in Individuals With and Without Knee Osteoarthritis.
    Booker SQ, Sibille KT, Terry EL, Cardoso JS, Goodin BR, Sotolongo A, Staud R, Redden DT, Bradley LA, Fillingim RB, Bartley EJ
    Clin J Pain, 2020 Aug, 36(8): 569-577
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  14. Antihypertensive drugs and risk of COVID-19?
    Brown JD
    Lancet Respir Med, 2020 May, 8(5): e28
    https://doi.org/10.1016/S2213-2600(20)30158-2 | PMID: 32222168 | PMCID: PMC7194728
    Citations: 20 | AltScore: 14.58
  15. Potential Adverse Drug Events with Tetrahydrocannabinol (THC) Due to Drug-Drug Interactions.
    Brown JD
    J Clin Med, 2020 Mar 27, 9(4):
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    Citations: 4 | AltScore: 22.6
  16. Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study.
    Brown JD, Alipour-Haris G, Pahor M, Manini TM
    J Clin Med, 2020 Nov 22, 9(11):
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    Citations: 2 | AltScore: 1.85
  17. Characteristics of Older Adults Who Were Early Adopters of Medical Cannabis in the Florida Medical Marijuana Use Registry.
    Brown JD, Costales B, van Boemmel-Wegmann S, Goodin AJ, Segal R, Winterstein AG
    J Clin Med, 2020 Apr 18, 9(4):
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    Citations: 2 | AltScore: NA
  18. Trajectories of Short Physical Performance Battery Are Strongly Associated with Future Major Mobility Disability: Results from the LIFE Study.
    Brown JD, Lo-Ciganic WH, Shao H, Pahor M, Manini TM
    J Clin Med, 2020 Jul 22, 9(8):
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  19. Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic.
    Brown JD, Vouri SM, Manini TM
    Res Social Adm Pharm, 2020 Nov 12
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    Citations: 4 | AltScore: 13.53
  20. Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.
    Clark DJ, Chatterjee SA, Skinner JW, Lysne PE, Sumonthee C, Wu SS, Cohen RA, Rose DK, Woods AJ
    Neuromodulation, 2020 Aug 18
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  21. Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging.
    Correa-de-Araujo R, Addison O, Miljkovic I, Goodpaster BH, Bergman BC, Clark RV, Elena JW, Esser KA, Ferrucci L, Harris-Love MO, Kritchevsky SB, Lorbergs A, Shepherd JA, Shulman GI, Rosen CJ
    Front Physiol, 2020, 11: 963
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    Citations: 9 | AltScore: 9.5
  22. Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
    Cox MC, Brakenridge SC, Stortz JA, Hawkins RB, Darden DB, Ghita GL, Mohr AM, Moldawer LL, Efron PA, Moore FA
    Am J Surg, 2020 Dec, 220(6): 1467-1474
    https://doi.org/10.1016/j.amjsurg.2020.07.016 | PMID: 32807383 | PMCID: PMC7731616
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  23. Pain, aging, and the brain: new pieces to a complex puzzle.
    Cruz-Almeida Y, Cole J
    Pain, 2020 Mar, 161(3): 461-463
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  24. Pain Severity and Interference in Different Parkinson's Disease Cognitive Phenotypes.
    Cruz-Almeida Y, Crowley SJ, Tanner J, Price CC
    J Pain Res, 2020, 13: 3493-3497
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  25. The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study.
    Custodero C, Anton SD, Beavers DP, Mankowski RT, Lee SA, McDermott MM, Fielding RA, Newman AB, Tracy RP, Kritchevsky SB, Ambrosius WT, Pahor M, Manini TM, ENRGISE study investigators.
    Arch Gerontol Geriatr, 2020 Sep - Oct, 90: 104131
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    Citations: 1 | AltScore: 0.5
  26. The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019.
    Darden DB, Hawkins RB, Larson SD, Iovine NM, Prough DS, Efron PA
    Crit Care Explor, 2020 Apr, 2(4): e0109
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    Citations: 5 | AltScore: 15.3
  27. Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
    Darden DB, Stortz JA, Hollen MK, Cox MC, Apple CG, Hawkins RB, Rincon JC, Lopez MC, Wang Z, Navarro E, Hagen JE, Parvataneni HK, Brusko MA, Kladde M, Bacher R, Brumback BA, Brakenridge SC, Baker HV, Cogle CR, Mohr AM, Efron PA
    Front Immunol, 2020, 11: 1289
    https://doi.org/10.3389/fimmu.2020.01289 | PMID: 32670283 | PMCID: PMC7326804
    Citations: 1 | AltScore: 0.75
  28. Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
    Douma LG, Crislip GR, Cheng KY, Barral D, Masten S, Holzworth M, Roig E, Glasford K, Beguiristain K, Li W, Bratanatawira P, Lynch IJ, Cain BD, Wingo CS, Gumz ML
    Can J Physiol Pharmacol, 2020 Sep, 98(9): 579-586
    https://doi.org/10.1139/cjpp-2019-0688 | PMID: 32437627 | PMCID: PMC7605171
    Citations: 2 | AltScore: NA
  29. EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells.
    Douma LG, Solocinski K, Masten SH, Barral DH, Barilovits SJ, Jeffers LA, Alder KD, Patel R, Wingo CS, Brown KD, Cain BD, Gumz ML
    Front Physiol, 2020, 11: 209
    https://doi.org/10.3389/fphys.2020.00209 | PMID: 32231591 | PMCID: PMC7082230
    Citations: 1 | AltScore: 5.1
  30. A QST-based Pain Phenotype in Adults With Sickle Cell Disease: Sensitivity and Specificity of Quality Descriptors.
    Dyal BW, Ezenwa MO, Yoon SL, Fillingim RB, Yao Y, Schlaeger JM, Suarez ML, Wang ZJ, Molokie RE, Wilkie DJ
    Pain Pract, 2020 Feb, 20(2): 168-178
    https://doi.org/10.1111/papr.12841 | PMID: 31553824 | PMCID: PMC7018539
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  31. Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.
    Febo M, Rani A, Yegla B, Barter J, Kumar A, Wolff CA, Esser K, Foster TC
    Front Aging Neurosci, 2020, 12: 34
    https://doi.org/10.3389/fnagi.2020.00034 | PMID: 32153384 | PMCID: PMC7044155
    Citations: 2 | AltScore: 4
  32. Incident Instrumental Activities of Daily Living Difficulty in Older Adults: Which Comes First? Findings From the Advanced Cognitive Training for Independent and Vital Elderly Study.
    Feger DM, Willis SL, Thomas KR, Marsiske M, Rebok GW, Felix C, Gross AL
    Front Neurol, 2020, 11: 550577
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    Citations: 1 | AltScore: NA
  33. Pain relief for osteoarthritis through combined treatment (PROACT): Protocol for a randomized controlled trial of mindfulness meditation combined with transcranial direct current stimulation in non-Hispanic black and white adults with knee osteoarthritis.
    Fillingim RB, Woods AJ, Ahn H, Wu SS, Redden DT, Lai S, Deshpande H, Deutsch G, Sibille KT, Staud R, Zeidan F, Goodin BR
    Contemp Clin Trials, 2020 Nov, 98: 106159
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  34. Relationship Between Nicotine Intake and Reward Function in Rats With Intermittent Short Versus Long Access to Nicotine.
    Geste JR, Levin B, Wilks I, Pompilus M, Zhang X, Esser KA, Febo M, O'Dell L, Bruijnzeel AW
    Nicotine Tob Res, 2020 Feb 6, 22(2): 213-223
    https://doi.org/10.1093/ntr/ntz052 | PMID: 30958557 | PMCID: PMC7297112
    Citations: 2 | AltScore: 1
  35. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
    Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB, Lifestyle Interventions and Independence for Elders Study Group.
    J Am Geriatr Soc, 2020 Mar, 68(3): 619-624
    https://doi.org/10.1111/jgs.16274 | PMID: 31867713 | PMCID: PMC8061638
    Citations: | AltScore: 22.45
  36. Associations of Peripheral Artery Disease With Calf Skeletal Muscle Mitochondrial DNA Heteroplasmy.
    Gonzalez-Freire M, Moore AZ, Peterson CA, Kosmac K, McDermott MM, Sufit RL, Guralnik JM, Polonsky T, Tian L, Kibbe MR, Criqui MH, Li L, Leeuwenburgh C, Ferrucci L
    J Am Heart Assoc, 2020 Apr 7, 9(7): e015197
    https://doi.org/10.1161/JAHA.119.015197 | PMID: 32200714 | PMCID: PMC7428597
    Citations: 3 | AltScore: 1.5
  37. Auditory Processing Deficits Are Selectively Associated with Medial Temporal Lobe Mnemonic Function and White Matter Integrity in Aging Macaques.
    Gray DT, Umapathy L, De La Pe?a NM, Burke SN, Engle JR, Trouard TP, Barnes CA
    Cereb Cortex, 2020 May 14, 30(5): 2789-2803
    https://doi.org/10.1093/cercor/bhz275 | PMID: 31833551 | PMCID: PMC7197075
    Citations: 1 | AltScore: 2.25
  38. MicroRNA predicts cognitive performance in healthy older adults.
    Gullett JM, Chen Z, O'Shea A, Akbar M, Bian J, Rani A, Porges EC, Foster TC, Woods AJ, Modave F, Cohen RA
    Neurobiol Aging, 2020 Nov, 95: 186-194
    https://doi.org/10.1016/j.neurobiolaging.2020.07.023 | PMID: 32846274 | PMCID: PMC7606424
    Citations: 2 | AltScore: NA
  39. International Classification of Diseases, Tenth Revision, Clinical Modification social determinants of health codes are poorly used in electronic health records.
    Guo Y, Chen Z, Xu K, George TJ, Wu Y, Hogan W, Shenkman EA, Bian J
    Medicine (Baltimore), 2020 Dec 24, 99(52): e23818
    https://doi.org/10.1097/MD.0000000000023818 | PMID: 33350768 | PMCID: PMC7769291
    Citations: | AltScore: 1
  40. Ticking for Metabolic Health: The Skeletal-Muscle Clocks.
    Gutierrez-Monreal MA, Harmsen JF, Schrauwen P, Esser KA
    Obesity (Silver Spring), 2020 Jul, 28 Suppl 1: S46-S54
    https://doi.org/10.1002/oby.22826 | PMID: 32468732 | PMCID: PMC7381376
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  41. Contributions of Hippocampal Volume to Cognition in Healthy Older Adults.
    Hardcastle C, O'Shea A, Kraft JN, Albizu A, Evangelista ND, Hausman HK, Boutzoukas EM, Van Etten EJ, Bharadwaj PK, Song H, Smith SG, Porges EC, Dekosky S, Hishaw GA, Wu SS, Marsiske M, Cohen R, Alexander GE, Woods AJ
    Front Aging Neurosci, 2020, 12: 593833
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  42. The Role of Resting-State Network Functional Connectivity in Cognitive Aging.
    Hausman HK, O'Shea A, Kraft JN, Boutzoukas EM, Evangelista ND, Van Etten EJ, Bharadwaj PK, Smith SG, Porges E, Hishaw GA, Wu S, DeKosky S, Alexander GE, Marsiske M, Cohen R, Woods AJ
    Front Aging Neurosci, 2020, 12: 177
    https://doi.org/10.3389/fnagi.2020.00177 | PMID: 32595490 | PMCID: PMC7304333
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  43. Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness.
    Hawkins RB, Stortz JA, Holden DC, Wang Z, Raymond SL, Cox MC, Brakenridge SC, Moore FA, Moldawer LL, Efron PA
    Surgery, 2020 Mar, 167(3): 646-652
    https://doi.org/10.1016/j.surg.2019.11.018 | PMID: 31898953 | PMCID: PMC7028489
    Citations: 3 | AltScore: 2
  44. Clinical Trial Generalizability Assessment in the Big Data Era: A Review.
    He Z, Tang X, Yang X, Guo Y, George TJ, Charness N, Quan Hem KB, Hogan W, Bian J
    Clin Transl Sci, 2020 Jul, 13(4): 675-684
    https://doi.org/10.1111/cts.12764 | PMID: 32058639 | PMCID: PMC7359942
    Citations: 8 | AltScore: 0.75
  45. Plasma Concentrations of Select Inflammatory Cytokines Predicts Pain Intensity 48 Hours Post-Shoulder Muscle Injury.
    Hedderson WC, Borsa PA, Fillingim RB, Coombes SA, Hass CJ, George SZ
    Clin J Pain, 2020 Oct, 36(10): 775-781
    https://doi.org/10.1097/AJP.0000000000000861 | PMID: 32675582 | PMCID: PMC7484373
    Citations: | AltScore: 2
  46. Sex differences in age-related impairments vary across cognitive and physical assessments in rats.
    Hernandez AR, Truckenbrod LM, Campos KT, Williams SA, Burke SN
    Behav Neurosci, 2020 Apr, 134(2): 69-81
    https://doi.org/10.1037/bne0000352 | PMID: 31886694 | PMCID: PMC7078049
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  47. A Cross-species Model of Dual-Task Walking in Young and Older Humans and Rats.
    Hernandez AR, Winesett SP, Federico QP, Williams SA, Burke SN, Clark DJ
    Front Aging Neurosci, 2020, 12: 276
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  48. Changes in Opioid Use After Florida's Restriction Law for Acute Pain Prescriptions.
    Hincapie-Castillo JM, Goodin A, Possinger MC, Usmani SA, Vouri SM
    JAMA Netw Open, 2020 Feb 5, 3(2): e200234
    https://doi.org/10.1001/jamanetworkopen.2020.0234 | PMID: 32108887 | PMCID: PMC7049083
    Citations: 6 | AltScore: 116.948
  49. OPRM1, OPRK1, and COMT genetic polymorphisms associated with opioid effects on experimental pain: a randomized, double-blind, placebo-controlled study.
    Ho KWD, Wallace MR, Staud R, Fillingim RB
    Pharmacogenomics J, 2020 Jun, 20(3): 471-481
    https://doi.org/10.1038/s41397-019-0131-z | PMID: 31806881 | PMCID: PMC7260086
    Citations: 1 | AltScore: 23.2
  50. The Role of Intranasal Oxytocin on Social Cognition: An Integrative Human Lifespan Approach.
    Horta M, Pehlivanoglu D, Ebner NC
    Curr Behav Neurosci Rep, 2020 Dec, 7(4): 175-192
    https://doi.org/10.1007/s40473-020-00214-5 | PMID: 33717829 | PMCID: PMC7951958
    Citations: 1 | AltScore: 8.35
  51. The Hematopoietic Stem/Progenitor Cell Response to Hemorrhage, Injury and Sepsis: A Review of Pathophysiology.
    Kelly LS, Darden DB, Fenner BP, Efron PA, Mohr AM
    Shock, 2020 Nov 23
    https://doi.org/10.1097/SHK.0000000000001699 | PMID: 33234838 | PMCID: PMC8141062
    Citations: 1 | AltScore: 0.5
  52. Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.
    Kelly MN, Smith DN, Sunshine MD, Ross A, Zhang X, Gumz ML, Esser KA, Mitchell GS
    Am J Physiol Regul Integr Comp Physiol, 2020 Jun 1, 318(6): R1058-R1067
    https://doi.org/10.1152/ajpregu.00010.2020 | PMID: 32348679 | PMCID: PMC7311680
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  53. Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock.
    Kemler D, Wolff CA, Esser KA
    J Physiol, 2020 Sep, 598(17): 3631-3644
    https://doi.org/10.1113/JP279779 | PMID: 32537739 | PMCID: PMC7479806
    Citations: 6 | AltScore: 126.31
  54. Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan.
    Kim MJ, Han C, White K, Park HJ, Ding D, Boyd K, Rothenberger C, Bose U, Carmichael P, Linser PJ, Tanokura M, Salvi R, Someya S
    Exp Gerontol, 2020 Nov, 141: 111078
    https://doi.org/10.1016/j.exger.2020.111078 | PMID: 32866605 | PMCID: PMC7680416
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  55. Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease.
    Kosmac K, Gonzalez-Freire M, McDermott MM, White SH, Walton RG, Sufit RL, Tian L, Li L, Kibbe MR, Criqui MH, Guralnik JM, S Polonsky T, Leeuwenburgh C, Ferrucci L, Peterson CA
    J Am Heart Assoc, 2020 May 18, 9(10): e015929
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    Citations: 2 | AltScore: 3.25
  56. G Protein-Coupled Estrogen Receptor: Rapid Effects on Hippocampal-Dependent Spatial Memory and Synaptic Plasticity.
    Kumar A, Foster TC
    Front Endocrinol (Lausanne), 2020, 11: 385
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  57. Determinants of Adherence in Time-Restricted Feeding in Older Adults: Lessons from a Pilot Study.
    Lee SA, Sypniewski C, Bensadon BA, McLaren C, Donahoo WT, Sibille KT, Anton S
    Nutrients, 2020 Mar 24, 12(3):
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    Citations: 4 | AltScore: 1
  58. Postdischarge Intervention for Stroke Caregivers: Protocol for a Randomized Controlled Trial.
    LeLaurin JH, Lamba AH, Eliazar-Macke ND, Schmitzberger MK, Freytes IM, Dang S, Vogel WB, Levy CE, Klanchar SA, Beyth RJ, Shorr RI, Uphold CR
    JMIR Res Protoc, 2020 Nov 11, 9(11): e21799
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    Citations: | AltScore: NA
  59. Clinical Reasoning: A 45-year-old man with progressive insomnia and psychiatric and motor symptoms.
    Lima JEE, Youn TS, Robinson C, Gilmore EJ, Schrag M, Sanamandra S, Maciel CB
    Neurology, 2020 Mar 17, 94(11): e1213-e1218
    https://doi.org/10.1212/WNL.0000000000009098 | PMID: 32107325 | PMCID: PMC7220232
    Citations: 1 | AltScore: 8.95
  60. Predicting Weight Loss Using Psychological and Behavioral Factors: The POUNDS LOST Trial.
    Liu X, Hanseman DJ, Champagne CM, Bray GA, Qi L, Williamson DA, Anton SD, Sacks FM, Tong J
    J Clin Endocrinol Metab, 2020 Apr 1, 105(4):
    pii: dgz236. https://doi.org/10.1210/clinem/dgz236 | PMID: 31802116 | PMCID: PMC7067534
    Citations: | AltScore: 12.1
  61. Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
    Loftus TJ, Kannan KB, Mira JC, Brakenridge SC, Efron PA, Mohr AM
    Shock, 2020 Oct, 54(4): 482-487
    https://doi.org/10.1097/SHK.0000000000001506 | PMID: 31904616 | PMCID: PMC7332401
    Citations: 1 | AltScore: 1
  62. Delayed interhospital transfer of critically ill patients with surgical sepsis.
    Loftus TJ, Wu Q, Wang Z, Lysak N, Moore FA, Bihorac A, Efron PA, Mohr AM, Brakenridge SC
    J Trauma Acute Care Surg, 2020 Jan, 88(1): 169-175
    https://doi.org/10.1097/TA.0000000000002476 | PMID: 31856021 | PMCID: PMC6927529
    Citations: 1 | AltScore: 17.2
  63. BTBD9 and dopaminergic dysfunction in the pathogenesis of restless legs syndrome.
    Lyu S, Doroodchi A, Xing H, Sheng Y, DeAndrade MP, Yang Y, Johnson TL, Clemens S, Yokoi F, Miller MA, Xiao R, Li Y
    Brain Struct Funct, 2020 Jul, 225(6): 1743-1760
    https://doi.org/10.1007/s00429-020-02090-x | PMID: 32468214 | PMCID: PMC7429108
    Citations: 3 | AltScore: 1.25
  64. Nursing Care for Hospitalized Older Adults With and Without Cognitive Impairment.
    Macieira TGR, Yao Y, Smith MB, Bian J, Wilkie DJ, Keenan GM
    Nurs Res, 2020 Mar/Apr, 69(2): 116-126
    https://doi.org/10.1097/NNR.0000000000000402 | PMID: 31972847 | PMCID: PMC7050380
    Citations: | AltScore: 2.35
  65. Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
    Mankowski RT, Anton SD, Ghita GL, Brumback B, Cox MC, Mohr AM, Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA
    J Am Geriatr Soc, 2020 Apr 15, 68(9): 1962-1969
    https://doi.org/10.1111/jgs.16435 | PMID: 32294254 | PMCID: PMC7654284
    Citations: 8 | AltScore: 7.85
  66. Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults - A pilot study.
    Mankowski RT, You L, Buford TW, Leeuwenburgh C, Manini TM, Schneider S, Qiu P, Anton SD
    Exp Gerontol, 2020 Mar, 131: 110821
    https://doi.org/10.1016/j.exger.2019.110821 | PMID: 31891746 | PMCID: PMC8168448
    Citations: 5 | AltScore: 11.3
  67. Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial.
    McDermott MM, Criqui MH, Domanchuk K, Ferrucci L, Guralnik JM, Kibbe MR, Kosmac K, Kramer CM, Leeuwenburgh C, Li L, Lloyd-Jones D, Peterson CA, Polonsky TS, Stein JH, Sufit R, Van Horn L, Villarreal F, Zhang D, Zhao L, Tian L
    Circ Res, 2020 Feb 28, 126(5): 589-599
    https://doi.org/10.1161/CIRCRESAHA.119.315600 | PMID: 32078436 | PMCID: PMC7141749
    Citations: 4 | AltScore: 212.65
  68. Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease.
    McDermott MM, Guralnik JM, Tian L, Zhao L, Polonsky TS, Kibbe MR, Criqui MH, Zhang D, Conte MS, Domanchuk K, Li L, Sufit R, Leeuwenburgh C, Ferrucci L
    J Vasc Surg, 2020 Mar, 71(3): 988-1001
    https://doi.org/10.1016/j.jvs.2019.05.058 | PMID: 31870756 | PMCID: PMC7141750
    Citations: 2 | AltScore: 3.2
  69. Optimizing identification of resistant hypertension: Computable phenotype development and validation.
    McDonough CW, Babcock K, Chucri K, Crawford DC, Bian J, Modave F, Cooper-DeHoff RM, Hogan WR
    Pharmacoepidemiol Drug Saf, 2020 Nov, 29(11): 1393-1401
    https://doi.org/10.1002/pds.5095 | PMID: 32844549 | PMCID: PMC7754782
    Citations: | AltScore: 2.7
  70. Understanding the relationship between features associated with pain-related disability in people with painful temporomandibular disorder: an exploratory structural equation modeling approach.
    Miller VE, Chen DG, Barrett D, Poole C, Golightly YM, Sanders AE, Ohrbach R, Greenspan JD, Fillingim RB, Slade GD
    Pain, 2020 Dec, 161(12): 2710-2719
    https://doi.org/10.1097/j.pain.0000000000001976 | PMID: 32639367 | PMCID: PMC7669591
    Citations: | AltScore: 5.8
  71. Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults.
    Montesino-Goicolea S, Valdes-Hernandez PA, Hoyos L, Woods AJ, Cohen R, Huo Z, Riley JL 3rd, Porges EC, Fillingim RB, Cruz-Almeida Y
    J Pain Res, 2020, 13: 2389-2400
    https://doi.org/10.2147/JPR.S260611 | PMID: 33061554 | PMCID: PMC7522519
    Citations: 1 | AltScore: NA
  72. Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.
    Motwani K, Peters LD, Vliegen WH, El-Sayed AG, Seay HR, Lopez MC, Baker HV, Posgai AL, Brusko MA, Perry DJ, Bacher R, Larkin J, Haller MJ, Brusko TM
    Front Immunol, 2020, 11: 611
    https://doi.org/10.3389/fimmu.2020.00611 | PMID: 32351504 | PMCID: PMC7174770
    Citations: 2 | AltScore: 16.4
  73. Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
    Ozrazgat-Baslanti T, Loftus TJ, Mohandas R, Wu Q, Brakenridge S, Brumback B, Efron PA, Anton S, Moore FA, Moldawer LL, Segal MS, Bihorac A, Sepsis and Critical Illness Research Center Investigators.
    Ann Surg, 2020 Nov 13
    https://doi.org/10.1097/SLA.0000000000004360 | PMID: 33196489 | PMCID: PMC8116352
    Citations: 1 | AltScore: 14.05
  74. Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.
    Pahor M, Guralnik JM, Anton SD, Ambrosius WT, Blair SN, Church TS, Espeland MA, Fielding RA, Gill TM, Glynn NW, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Williamson JD
    J Am Geriatr Soc, 2020 Apr, 68(4): 872-881
    https://doi.org/10.1111/jgs.16365 | PMID: 32105353 | PMCID: PMC7187344
    Citations: 5 | AltScore: 13.35
  75. Pain resilience moderates the influence of negative pain beliefs on movement-evoked pain in older adults.
    Palit S, Fillingim RB, Bartley EJ
    J Behav Med, 2020 Oct, 43(5): 754-763
    https://doi.org/10.1007/s10865-019-00110-8 | PMID: 31620973 | PMCID: PMC7160029
    Citations: 2 | AltScore: NA
  76. Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
    Park HJ, Kim MJ, Han C, White K, Ding D, Boyd K, Salvi R, Someya S
    Exp Gerontol, 2020 May, 133: 110872
    https://doi.org/10.1016/j.exger.2020.110872 | PMID: 32044382 | PMCID: PMC7062562
    Citations: 1 | AltScore: NA
  77. Explainable artificial intelligence models using real-world electronic health?record data: a systematic scoping review.
    Payrovnaziri SN, Chen Z, Rengifo-Moreno P, Miller T, Bian J, Chen JH, Liu X, He Z
    J Am Med Inform Assoc, 2020 Jul 1, 27(7): 1173-1185
    https://doi.org/10.1093/jamia/ocaa053 | PMID: 32417928 | PMCID: PMC7647281
    Citations: 4 | AltScore: 6
  78. Tri-Phasic Model ofOxytocin (TRIO): A systematic conceptual review of oxytocin-related ERP research.
    Pehlivanoglu D, Myers E, Ebner NC
    Biol Psychol, 2020 Jul, 154: 107917
    https://doi.org/10.1016/j.biopsycho.2020.107917 | PMID: 32512020 | PMCID: PMC7556712
    Citations: 1 | AltScore: 1.6
  79. Anxiety and executive functions in mid-to-late life: the moderating role of sleep.
    Perez E, Dzierzewski JM, Aiken-Morgan AT, McCrae CS, Buman MP, Giacobbi PR, Roberts BL, Marsiske M
    Aging Ment Health, 2020 Sep, 24(9): 1459-1465
    https://doi.org/10.1080/13607863.2019.1663492 | PMID: 31512489 | PMCID: PMC7065938
    Citations: 1 | AltScore: NA
  80. Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.
    Pham P, Schmidt S, Lesko L, Lip GYH, Brown JD
    JAMA Netw Open, 2020 Apr 1, 3(4): e203593
    https://doi.org/10.1001/jamanetworkopen.2020.3593 | PMID: 32329770 | PMCID: PMC7182798
    Citations: 1 | AltScore: 57.8
  81. Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.
    Picca A, Saini SK, Mankowski RT, Kamenov G, Anton SD, Manini TM, Buford TW, Wohlgemuth SE, Xiao R, Calvani R, Coelho-J?nior HJ, Landi F, Bernabei R, Hood DA, Marzetti E, Leeuwenburgh C
    Cells, 2020 Dec 2, 9(12):
    pii: E2579. https://doi.org/10.3390/cells9122579 | PMID: 33276460 | PMCID: PMC7760001
    Citations: 1 | AltScore: 0.75
  82. Longitudinal effect of transcranial direct current stimulation on knee osteoarthritis patients measured by functional infrared spectroscopy: a pilot study.
    Pollonini L, Miao H, Ahn H
    Neurophotonics, 2020 Apr, 7(2): 025004
    https://doi.org/10.1117/1.NPh.7.2.025004 | PMID: 32411812 | PMCID: PMC7203445
    Citations: 2 | AltScore: 0.25
  83. Artificial intelligence approaches to improve kidney care.
    Rashidi P, Bihorac A
    Nat Rev Nephrol, 2020 Feb, 16(2): 71-72
    https://doi.org/10.1038/s41581-019-0243-3 | PMID: 31873197 | PMCID: PMC7591106
    Citations: 5 | AltScore: 41.8
  84. Prospective Validation of a Transcriptomic Metric in Severe Trauma.
    Raymond SL, Hawkins RB, Wang Z, Mira JC, Stortz JA, Han F, Lanz JD, Hennessy LV, Brumback BA, Baker HV, Efron PA, Brakenridge SC, Xiao W, Tompkins RG, Cuschieri J, Moore FA, Maier RV, Moldawer LL
    Ann Surg, 2020 May, 271(5): 802-810
    https://doi.org/10.1097/SLA.0000000000003204 | PMID: 30688688 | PMCID: PMC6656642
    Citations: 8 | AltScore: 2.25
  85. Immunotherapies for COVID-19: lessons learned from sepsis.
    Remy KE, Brakenridge SC, Francois B, Daix T, Deutschman CS, Monneret G, Jeannet R, Laterre PF, Hotchkiss RS, Moldawer LL
    Lancet Respir Med, 2020 Oct, 8(10): 946-949
    https://doi.org/10.1016/S2213-2600(20)30217-4 | PMID: 32444269 | PMCID: PMC7195015
    Citations: 39 | AltScore: 60.2
  86. Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli.
    Riley JL 3rd, Cruz-Almeida Y, Staud R, Fillingim RB
    Pain Rep, 2020 Jan-Feb, 5(1): e796
    https://doi.org/10.1097/PR9.0000000000000796 | PMID: 32072094 | PMCID: PMC7004505
    Citations: | AltScore: 3.1
  87. Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease.
    Saini SK, Li L, Peek CB, Kosmac K, Polonsky TS, Tian L, Criqui MH, Ferrucci L, Guralnik JM, Kibbe M, Sufit RL, Leeuwenburgh C, McDermott MM
    Exp Gerontol, 2020 Oct 15, 140: 111048
    https://doi.org/10.1016/j.exger.2020.111048 | PMID: 32755612
    Citations: 1 | AltScore: NA
  88. Reproducibility across single-cell RNA-seq protocols for spatial ordering analysis.
    Seirup M, Chu LF, Sengupta S, Leng N, Browder H, Kapadia K, Shafer CM, Duffin B, Elwell AL, Bolin JM, Swanson S, Stewart R, Kendziorski C, Thomson JA, Bacher R
    PLoS One, 2020, 15(9): e0239711
    https://doi.org/10.1371/journal.pone.0239711 | PMID: 32986734 | PMCID: PMC7521718
    Citations: | AltScore: NA
  89. Reliability and Validity of the Short-Form 12 Item Version 2 (SF-12v2) Health-Related Quality of Life Survey and Disutilities Associated with Relevant Conditions in the U.S. Older Adult Population.
    Shah CH, Brown JD
    J Clin Med, 2020 Feb 29, 9(3):
    pii: E661. https://doi.org/10.3390/jcm9030661 | PMID: 32121371 | PMCID: PMC7141358
    Citations: 2 | AltScore: 1.85
  90. Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension.
    Sharma RK, Oliveira AC, Yang T, Karas MM, Li J, Lobaton GO, Aquino VP, Robles-Vera I, de Kloet AD, Krause EG, Bryant AJ, Verma A, Li Q, Richards EM, Raizada MK
    Hypertension, 2020 Jul, 76(1): 206-216
    https://doi.org/10.1161/HYPERTENSIONAHA.120.14931 | PMID: 32418496 | PMCID: PMC7505091
    Citations: 8 | AltScore: 9.2
  91. Which Spreading Depolarizations Are Deleterious To Brain Tissue?
    Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, Jones SC, Kirov SA, Lindquist BE, Maciel CB, Okonkwo D, Reinhart KM, Robertson RM, Rosenthal ES, Watanabe T, Hartings JA
    Neurocrit Care, 2020 Feb, 32(1): 317-322
    https://doi.org/10.1007/s12028-019-00776-7 | PMID: 31388871 | PMCID: PMC7002178
    Citations: 8 | AltScore: NA
  92. Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
    Smith G, Rani A, Kumar A, Barter J, Foster TC
    J Neurosci, 2020 Jun 17, 40(25): 4888-4899
    https://doi.org/10.1523/JNEUROSCI.2944-19.2020 | PMID: 32376783 | PMCID: PMC7326352
    Citations: 1 | AltScore: 20.35
  93. Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging.
    Someya S, Kim MJ
    Hear Res, 2020 May 28, 402: 108002
    https://doi.org/10.1016/j.heares.2020.108002 | PMID: 32600853 | PMCID: PMC7704621
    Citations: | AltScore: NA
  94. Improving natural product research translation: From source to clinical trial.
    Sorkin BC, Kuszak AJ, Bloss G, Fukagawa NK, Hoffman FA, Jafari M, Barrett B, Brown PN, Bushman FD, Casper SJ, Chilton FH, Coffey CS, Ferruzzi MG, Hopp DC, Kiely M, Lakens D, MacMillan JB, Meltzer DO, Pahor M, Paul J, Pritchett-Corning K, Quinney SK, Rehermann B, Setchell KDR, Sipes NS, Stephens JM, Taylor DL, Tiriac H, Walters MA, Xi D, Zappal? G, Pauli GF
    FASEB J, 2020 Jan, 34(1): 41-65
    https://doi.org/10.1096/fj.201902143R | PMID: 31914647 | PMCID: PMC7470648
    Citations: 6 | AltScore: 7.2
  95. Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study.
    Squires P, Pahor M, Manini TM, Vouri S, Brown JD
    J Clin Med, 2020 Sep 16, 9(9):
    pii: E2989. https://doi.org/10.3390/jcm9092989 | PMID: 32947839 | PMCID: PMC7564216
    Citations: | AltScore: NA
  96. Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study.
    Stortz JA, Cox MC, Hawkins RB, Ghita GL, Brumback BA, Mohr AM, Moldawer LL, Efron PA, Brakenridge SC, Moore FA
    Crit Care, 2020 May 7, 24(1): 203
    https://doi.org/10.1186/s13054-020-02917-3 | PMID: 32381107 | PMCID: PMC7206740
    Citations: 2 | AltScore: 4.1
  97. Efficacy and safety of propranolol for treatment of temporomandibular disorder pain: a randomized, placebo-controlled clinical trial.
    Tchivileva IE, Hadgraft H, Lim PF, Di Giosia M, Ribeiro-Dasilva M, Campbell JH, Willis J, James R, Herman-Giddens M, Fillingim RB, Ohrbach R, Arbes SJ Jr, Slade GD
    Pain, 2020 Aug, 161(8): 1755-1767
    https://doi.org/10.1097/j.pain.0000000000001882 | PMID: 32701836 | PMCID: PMC7390887
    Citations: 3 | AltScore: NA
  98. Neuropathic-Like Pain Symptoms in a Community-Dwelling Sample with or at Risk for Knee Osteoarthritis.
    Terry EL, Booker SQ, Cardoso JS, Sibille KT, Bartley EJ, Glover TL, Vaughn IA, Thompson KA, Bulls HW, Addison AS, Staud R, Hughes LB, Edberg JC, Redden DT, Bradley LA, Goodin BR, Fillingim RB
    Pain Med, 2020 Jan 1, 21(1): 125-137
    https://doi.org/10.1093/pm/pnz112 | PMID: 31150093 | PMCID: PMC6953341
    Citations: 2 | AltScore: 4.35
  99. Everyday Discrimination in Adults with Knee Pain: The Role of Perceived Stress and Pain Catastrophizing.
    Terry EL, Fullwood MD, Booker SQ, Cardoso JS, Sibille KT, Glover TL, Thompson KA, Addison AS, Goodin BR, Staud R, Hughes LB, Bradley LA, Redden DT, Bartley EJ, Fillingim RB
    J Pain Res, 2020, 13: 883-895
    https://doi.org/10.2147/JPR.S235632 | PMID: 32431537 | PMCID: PMC7200232
    Citations: 1 | AltScore: 1.5
  100. Geospatial Analyses of Pain Intensity and Opioid Unit Doses Prescribed on the Day of Discharge Following Orthopedic Surgery.
    Tighe P, Modave F, Horodyski M, Marsik M, Lipori G, Fillingim R, Hu H, Hagen J
    Pain Med, 2020 Aug 1, 21(8): 1644-1662
    https://doi.org/10.1093/pm/pnz311 | PMID: 31800063 | PMCID: PMC7530566
    Citations: | AltScore: 1.5
  101. Forty-two Million Ways to Describe Pain: Topic Modeling of 200,000 PubMed Pain-Related Abstracts Using Natural Language Processing and Deep Learning-Based Text Generation.
    Tighe PJ, Sannapaneni B, Fillingim RB, Doyle C, Kent M, Shickel B, Rashidi P
    Pain Med, 2020 Nov 1, 21(11): 3133-3160
    https://doi.org/10.1093/pm/pnaa061 | PMID: 32249306 | PMCID: PMC7685694
    Citations: | AltScore: 4.35
  102. Relative contribution of muscle strength, lean mass, and lower extremity motor function in explaining between-person variance in mobility in older adults.
    Wages NP, Simon JE, Clark LA, Amano S, Russ DW, Manini TM, Clark BC
    BMC Geriatr, 2020 Jul 28, 20(1): 255
    https://doi.org/10.1186/s12877-020-01656-y | PMID: 32723298 | PMCID: PMC7385889
    Citations: | AltScore: 1.5
  103. Detecting associations between dietary supplement intake and sentiments within mental disorder tweets.
    Wang Y, Zhao Y, Zhang J, Bian J, Zhang R
    Health Informatics J, 2020 Jun, 26(2): 803-815
    https://doi.org/10.1177/1460458219867231 | PMID: 31566452 | PMCID: PMC7103532
    Citations: 1 | AltScore: 0.25
  104. Agreement of Minimum Data Set 3.0 depression and behavioral symptoms with clinical diagnosis in a nursing home.
    Wei YJ, Solberg L, Chen C, Fillingim RB, Pahor M, DeKosky S, Winterstein AG
    Aging Ment Health, 2020 May 25 1-6
    https://doi.org/10.1080/13607863.2020.1758921 | PMID: 32447973 | PMCID: PMC7686050
    Citations: | AltScore: 2.1
  105. Exercise sets the muscle clock with a calcium assist.
    Wolff CA, Esser KA
    J Physiol, 2020 Dec, 598(24): 5591-5592
    https://doi.org/10.1113/JP280783 | PMID: 32949163 | PMCID: PMC7774824
    Citations: | AltScore: 11.15
  106. Federated Learning for Healthcare Informatics.
    Xu J, Glicksberg BS, Su C, Walker P, Bian J, Wang F
    J Healthc Inform Res, 2020 Nov 12 1-19
    https://doi.org/10.1007/s41666-020-00082-4 | PMID: 33204939 | PMCID: PMC7659898
    Citations: 1 | AltScore: NA
  107. Identifying relations of medications with adverse drug events using recurrent convolutional neural networks and gradient boosting.
    Yang X, Bian J, Fang R, Bjarnadottir RI, Hogan WR, Wu Y
    J Am Med Inform Assoc, 2020 Jan 1, 27(1): 65-72
    https://doi.org/10.1093/jamia/ocz144 | PMID: 31504605 | PMCID: PMC7489076
    Citations: 6 | AltScore: 0.25
  108. Clinical concept extraction using transformers.
    Yang X, Bian J, Hogan WR, Wu Y
    J Am Med Inform Assoc, 2020 Dec 9, 27(12): 1935-1942
    https://doi.org/10.1093/jamia/ocaa189 | PMID: 33120431 | PMCID: PMC7727351
    Citations: | AltScore: 1
  109. Measurement of Semantic Textual Similarity in Clinical Texts: Comparison of Transformer-Based Models.
    Yang X, He X, Zhang H, Ma Y, Bian J, Wu Y
    JMIR Med Inform, 2020 Nov 23, 8(11): e19735
    https://doi.org/10.2196/19735 | PMID: 33226350 | PMCID: PMC7721552
    Citations: | AltScore: 1
  110. Extracting Family History of Patients From Clinical Narratives: Exploring an End-to-End Solution With Deep Learning Models.
    Yang X, Zhang H, He X, Bian J, Wu Y
    JMIR Med Inform, 2020 Dec 15, 8(12): e22982
    https://doi.org/10.2196/22982 | PMID: 33320104 | PMCID: PMC7772072
    Citations: | AltScore: 2
  111. Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial.
    Yoon SL, Grundmann O, Williams JJ, Wu SS, Leeuwenburgh C, Huo Z, George TJ Jr
    Acupunct Med, 2020 Feb, 38(1): 53-60
    https://doi.org/10.1177/0964528419873670 | PMID: 31544469 | PMCID: PMC7724768
    Citations: | AltScore: NA
  112. Mining Twitter to Assess the Determinants of Health Behavior towards Palliative Care in the United States.
    Zhao Y, Zhang H, Huo J, Guo Y, Wu Y, Prosperi M, Bian J
    AMIA Jt Summits Transl Sci Proc, 2020, 2020: 730-739
    PMID: 32477696 | PMCID: PMC7233059
    Citations: | AltScore: NA
  113. Exploring Eating Disorder Topics on Twitter: Machine Learning Approach.
    Zhou S, Zhao Y, Bian J, Haynos AF, Zhang R
    JMIR Med Inform, 2020 Oct 30, 8(10): e18273
    https://doi.org/10.2196/18273 | PMID: 33124997 | PMCID: PMC7665945
    Citations: | AltScore: 2.35


EXTERNAL ADVISORY BOARD MEMBERS

Mary McDermott
Northwestern University
Serving since 2013 (8 years)

Roger Fielding, PhD
Tufts University
Serving since 2013 (8 years)

Barb Nicklas
Wake Forest University
Serving since 2019 (2 years)

Carlos Moraes
University of Miami
Serving since 2019 (2 years)


RECOGNITION AND AWARDS (2020-2021)
Carolyn Tucker, PhD (2021)
  • Member, Academy of Science, Engineering and Medicine of Florida (ASEMFL), 2021
Marco Pahor, MD (2021)
  • Fellow, Gerontological Society of America, 2021
  • Editorial Board, Journal of Gerontology: Medical Sciences, 2004-present
  • Consulting Editor, Aging Clinical and Experimental Research, 2000-present
  • Editorial Board, Journal of Nutrition, Health and Aging, 2002-present
  • Editorial Board, Journal of Frailty and Aging, 2016-present
Michael Marsiske, PhD (2020)
  • Recipient, Audrey Schumacher Classroom Teaching Award, University of Florida, 2020
Robert Mankowski, PhD (2020)
  • Recipient, Exemplary Teacher Award, College of Medicine, University of Florida, 2020-2021
Sanjay Ranka, PhD (2020)
  • Impact Award, IEEE Technical Committee on Cloud Computing, 2020
  • Top 50 Technical Visionaries Award, Intercon International Conference, 2020
Thomas Foster, PhD (2020)
  • Editorial Board, Aging Brain, 2020
Todd Manini, PhD (2020)
  • Associate Editor, Journals of Gerontology: Medical Sciences, 2020

MINORITY RESEARCH

General Brief Description of Minority Activities:

Steve Anton, PhD

·         Co-PI R33 AG056540: “The University of Florida Jacksonville Aging Studies Center (JAXASCENT)

·         Mentor for minority junior faculty member, Latoya O’Neal, Ph.D. (2017)

 

Yenisel Cruz-Almeida, MSPH, PhD

·         Pedro Valdes Hernandez, PhD- T32 Mentor

·         Soamy Montesino Goicolea, MD- Mentor

·         Carolina Maciel, MD- Junior Pepper Scholar Mentor

·         Desiree Lussier, PhD- Mentor

·         Keesha Roach, BSN, PhD- T32 Mentor

·         Sophia McCray- Honors Thesis Mentor

·         Vanessa Davila- Honors Thesis Mentor

·         Lorraine Hoyos- Medical Student, UCF, Research Mentor

 

Roger Fillingim, PhD

P30AG059297: “University of Florida Resource Center for Minority Aging Research

 

Todd Manini, PhD, Mentor 

·         Dottington Fullwood, PhD

 

Marco Pahor, MD

·         Co-PI R33 AG056540: “The University of Florida Jacksonville Aging Studies Center (JAXASCENT)

 

Carolyn Tucker, PhD

·         Human Foundation: “Health-Smart, Holistic Health and Wellness Centers Program to Promote Social Connection and Food Security among Minority, Underserved, and/or Low- Income Jacksonville Seniors”

 

·         PCORI: “Culturally Sensitive Primary Care Clinic-Based Interventions”




Minority Trainee(s):
  • M. Dottington Fullwood, PhD, Postdoctoral Fellow
    Dr. Fullwood is a rising scientist who is enthusiastic to expand his research focus to include aging, specifically understanding the connection between multidimensional impacts of chronic low back pain and mobility decline using mobile health technology in older minority adults. His research plan to assess the extent to assessment of behavioral interventions delivered to underserved older adult populations explains low back pain and mobility decline that leads to better ways to maintain and restore physical function to older adults. These objectives are directly aligned with the objective of the our JAX-ASCENT, which will provide excellent resources for him to pursue and achieve his research and training goals. Most importantly, he will work closely with JAX-ASCENT investigators who are invested in promoting an interdisciplinary academic environment by building lasting collaborations with clinical, behavioral and epidemiology scientists. His primary mentor—Dr. Anton—exemplifies this characteristic through his many collaborative research initiatives (see Biosketch). Moreover, Dr. Fullwood has assembled a mentoring team that contains experts in behavioral interventions to promote healthy aging, mobile health technology and multidimensional aspects of pain. His advisement from each mentor will vary in activities ranging from one-on-one individual meetings to directed readings and group discussion with his dream team of expert mentors. Dr. Fullwood will also participate in the many activities offered through the Claude D. Pepper Older Americans Independence Center (OAIC: P30AG028740) and Research Career Development Core (RCDC). He will follow specific training plans outlined by the RCDC co-leaders that will provide him clear benchmarks for meeting his career and research goals. He will attend weekly seminars focused on pain and aging and round table meetings with other more senior scholars.
  • Pedro Valdes Hernandez , PhD, Postdoctoral Fellow
    Over the 22-months of the supplement, the research and career development plan for Pedro is designed to promote his transition to independence as a researcher at the intersection of the fields of pain and aging. Results from a recent paper submitted by Dr. Valdes Hernandez revealed that chronic musculoskeletal pain in older adults may negatively impact specific cerebral circuits related to memory, language, motor planning, mobility and physical function (see Figure 1). These findings fueled Pedro’s avidity to delve into the fields of pain and aging, specifically investigating the mechanisms mediating the impact of pain on mobility and physical function in older adults. This critical gap in knowledge aligns quite well with the scientific theme of the UF OAIC. Pedro came to UF 18 months ago with no previous background in pain or aging research. His preliminary research training experiences have provided a foundation of knowledge and skills in these areas, enabling him to develop and implement innovative mechanism-based research protocols investigating pain in older adults. This Administrative Supplement would provide the opportunity for Pedro to pursue advanced training in pain, aging and mobility research in a more structured manner, allowing him the time to develop research interests and expertise, expediting his transition to research independence. His mid-term goal is to submit a K01 award by February 2021. His long-term goals are to: 1) excel in an academic institution as an independent translational neuroscientist with expertise in the fields of pain and aging; and 2) to contribute to the biomedical research community through scholarship and education with the ultimate goal of improving the life of older populations. The proposed research and career development plan is designed to help him achieve these career goals. Specifically, we propose a combination of experiential, training, pain and aging dedicated research and grant-writing activities. This will provide Pedro with hands-on research experience and increased knowledge in aging and pain. As a result of this training program, Pedro will be prepared to continue pain and geriatric research as a faculty member to greatly enhance his ability to pursue his long-term goal of an independent academic research career.

Minority Grant(s):