Claude D. Pepper Older Americans Independence Center

  Principal Investigator    Raymond Yung, M.D.  734-647-9746
  Program Administrator    Stephanie Gatica, B.A.  734-763-1118

Funded by the NIA as the nations first Geriatric Research and Training Center in 1989, the University of Michigan (UM) Pepper Center has evolved to meet the objectives of the OAIC program with successful competing renewals as an OAIC in 1994, 1999, 2004, 2009 and 2015. Thus, our Center is completing its 26th consecutive year of operation in 2015. The overall goal of the UM Pepper Center is to enhance the ability of older people to live independently by maintaining activities of daily living (ADLs) and to function well by maintaining mobility and levels of physical activity. Impairments of these factors predict poor health outcomes, poor quality of life, and mortality. Drawing on the large base of research currently underway in the fields of geriatrics and gerontology at UM, the UM Pepper Center fosters collaborative multidisciplinary research to integrate basic science, clinical science, and health services research relevant to the health care problems of older adults. The UM Pepper Center grant supports important research activities of the UM Geriatrics Center. Founded in 1987, the Geriatrics Center is the umbrella organization for geriatrics research, education, and patient care at the University of Michigan.

The specific goals of the UM Pepper Center are:

  1. To support research that will improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status.
  2. To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve this aim, the UM Pepper Center will work closely with other UM programs including the NIH funded Michigan Institute for Clinical and Health Research (MICHR), the home of the UM’s Clinical and Translational Science Award (CTSA).
  3. To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus.
  4. Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus.
  5. Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center’s research focus.

Faculty from the following UM Schools and Institutes are involved: the Institute of Gerontology, School of Public Health, Institute for Social Research, Medical School, College of Engineering, School of Nursing, School of Social Work, and College of Literature, Science, and the Arts. As of April 2014 there were 100 active NIA grants at the UM (29 of which are subawards for collaborative studies) with over $32 million/year of direct costs. The UM OAIC’s faculty participant data base includes a total of 239 current UM faculty who have 221 current external grants relevant to the UM Pepper Center’s focus totaling over $57 million/year direct costs.

  Aged Rodents
Leader 1:    Richard Miller, MD, PhD
CFAR, the Core Facility for Aged Rodents, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR will continue to serve the needs of Pepper Center investigators through four Specific Aims. Aim 1: We will continue work initiated in the previous five years on four varieties of mice: (a) Mice lacking PAPP-A, a protease that controls IGF-1 availability; (b) Mice overexpressing Syntaxin-4, a modulator of insulin sensitivity; (c) Mice in which p16-positive (senescent) cells can be pharmacologically deleted at adult ages; and (d) Mice treated by linagliptin, a modulator of post-prandial glucose spikes. Aim 2: We will develop new mouse models based on amino acid restriction, which follows our previous demonstration of slow aging and delayed disease in mice given limiting amounts of dietary methionine. Aim 3: We will explore the role of juvenile, adult, and liver-specific growth hormone responses to four drugs that extend mouse lifespan, specifically the TOR inhibitor rapamycin, the diabetic drug acarbose, the non-feminizing steroid 17-?-estradiol, and the anti-inflammatory agent NDGA. Aim 4: We will select one or two new mouse models per year, through collaboration with UM scientists, pilot project awardees, and colleagues at other research universities, for initial discovery research on questions related to the biology of aging, emphasizing interventions that alter metabolism and inflammation in ways that postpone late life illnesses and disabilities.

Leader 1:    James Ashton-Miller, PhD
The Biomechanics Core, (BC) enables its personnel to devote time to assist and train investigators in the conduct of new and expanded research on how metabolic disease and inflammation interact with age-related disease to determine key health outcomes related to mobility and functional status, the biomechanics of aging, and to the training of geriatric physicians and other clinicians in the biomechanics relevant to impaired mobility, falls and fall-related injuries, urinary incontinence and prolapse in the elderly. They also enable substantial use by Core-supported investigators of the equipment and facilities that exist in the Biomechanics Research Laboratory of the Department of Mechanical Engineering, as well as facilities in the Mobility Research Laboratory at the Geriatrics Center.

Design, Data, and Biostatistics Core (DDBC)
Leader 1:    Andrzej Galecki, PhD, MD
The primary goal of MDMAC is to provide methodological, data management, and analytical support to OAlC affiliated investigators, that address the focus of the OAlC - inflammation, metabolism, predictors and interventions for function of elderly people - as well as aging research in general. In collaboration with other OAIC Cores MDMAC will improve the quality of OAIC research studies, help foster development of junior researchers, will nurture forming interdisciplinary research groups, and ultimately enhance quality of research on late-life processes. MDMAC faculty will address the following four aims: 1. Advise and assist OAlC investigators in methodological design, data management, and analytical tasks in conducting projects; 2. Training and mentoring for OAlC investigators; 3. Facilitate the access of OAlC investigators to (large) archived survey and administrative secondary data sets describing elderly persons; 4. Undertake a limited number of internal efforts/projects to identify in existing literature or develop novel methodological approaches, and implement and disseminate them as software tools.

Human Subjects and Assessment
Leader 1:    Raymond Yung, MD
The University of Michigan Human Subjects and Assessment Core (HSAC) provides the infrastructure and resources critical to UM OAIC investigators performing clinical and translational research. The HSAC is closely aligned with the UM OAIC’s goal of integrating bench, clinical and outcome research with clinical practice. By working closely with the LAC, RCDC and the three other Resource Cores, the HSAC will assist OAIC-funded pilots and other externally funded projects (EPs) related the central research theme of the OAIC. Important priorities for the HSAC will be to support junior faculty new to aging research, the translation of basic research discoveries into human studies, and to support high impact clinical trials that have the promise of reducing disability and improving physical/cognitive function in older adults. The specific aims of the HSAC are 1) to facilitate access to human subjects and related data sets by investigators implementing research related to the central OAIC theme, 2) to provide training and consultation to OAIC researchers on issues related to experimental design (pre- and post-award), recruitment/retention of human subjects, translation from animal into human studies, techniques to compare national databases, 3) to expand and promote research on racial, ethnic, and cultural influences affecting the predisposing factors, metabolic/inflammatory mediators, and functional and health outcomes in older adults. In the present cycle, the HSAC has leveraged substantial institutional resources to expand the HSAC Registry of human volunteer subjects, and to provide longitudinal physical and functional assessment in a cohort of subjects within the HSAC registry who are at heightened risk of developing physical and cognitive impairment.

Leadership and Administrative Core (LAC)
Leader 1:    Raymond Yung, MD
A well-defined and effective Leadership Administrative Core (LAC) that supports the activities of the OAIC is already in place at the UM Geriatrics Center. The faculty and staff in the LAC have proven leadership and administrative skills. The LAC fosters interactions among the OAIC Program Director and Co-Program Director (who also serve as UM Geriatrics Center Director and Co-Director), the OAIC Core Directors and the leadership structure of the Institution as a whole. These interactions will be fostered by the administrative structure, which requires these interactions on a regular and ongoing basis, and by key advisory committees: the UM Geriatrics Center’s Research Operating Committee (ROC) and the OAIC External Advisory Board. The ROC provides coordination and oversight for all OAIC activities and an important advisory function for the OAIC Program Director and Co-Program Director. The membership of the ROC includes the Core Directors of the OAIC, four additional UM senior scientists, and Geriatrics Center administrative leaders

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Lona Mody, MD
The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center’s overall theme: improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status. The PESC will thus fund pilot research studies over a wide range of disciplines, from basic, pre-clinical, clinical patient-oriented research through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least three external reviewers and then be further evaluated by OAIC leaders for relevance to the Center objectives.

Research Education Component (REC)
Leader 1:    Neil B. Alexander, MD
The overarching goal of the UM OAIC Research Career Development Core (RCDC/KL2) is to recruit, select, support, mentor, and train junior faculty to become independent investigators in aging-related research and academic leaders in geriatrics and gerontology within their respective disciplines. A key additional objective is to train the next generation of investigators about the UM OAIC focus of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status. A substantial pool of UM junior faculty from a wide range of disciplines across the UM campus who are doing research relevant to the OAIC focus will be targeted to participate in the proposed RCDC training activities

  B. RESEARCH (0 Projects Listed)
  C. PILOT/EXPLORATORY PROJECTS (0 Pilot Projects Listed)
  No pilot/exploratory projects.
  D. DEVELOPMENT PROJECTS (0 Development Projects Listed)
  No development projects.
REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications

None specified.

  1. The Relationship of Loneliness to End-of-Life Experience in Older Americans: A Cohort Study.
    Abedini NC, Choi H, Wei MY, Langa KM, Chopra V
    J Am Geriatr Soc, 2020 Mar 3, 68(5): 1064-1071 | PMID: 32128789 | PMCID: PMC7234919
    Citations: 1 | AltScore: 46.6
  2. So Close and Yet So Irritating: Negative Relations and Implications for Well-being by Age and Closeness.
    Birditt KS, Sherman CW, Polenick CA, Becker L, Webster NJ, Ajrouch KJ, Antonucci TC
    J Gerontol B Psychol Sci Soc Sci, 2020 Jan 14, 75(2): 327-337 | PMID: 29596623 | PMCID: PMC7179808
    Citations: 2 | AltScore: 9.08
  3. Identifying predictors of upper extremity muscle elasticity with healthy aging.
    Chodock E, Hahn J, Setlock CA, Lipps DB
    J Biomech, 2020 Apr 16, 103: 109687 | PMID: 32147243 | PMCID: PMC7168868
    Citations: | AltScore: NA
  4. Optimizing Retention in a Pragmatic Trial of Community-Living Older Persons: The STRIDE Study.
    Gill TM, McGloin JM, Shelton A, Bianco LM, Skokos EA, Latham NK, Ganz DA, Nyquist LV, Wallace RB, Carnie MB, Dykes PC, Goehring LA, Doyle M, Charpentier PA, Greene EJ, Araujo KL
    J Am Geriatr Soc, 2020 Mar 25 | PMID: 32212395
    Citations: | AltScore: 2.85
  5. ResearchCOVID-19 Preparedness in Michigan Nursing Homes.
    Jones KM, Mantey J, Mills JP, Montoya A, Min L, Gibson K, Mody L
    J Am Geriatr Soc, 2020 May, 68(5): 937-939 | PMID: 32293023 | PMCID: PMC7262293
    Citations: | AltScore: 96.45
  6. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
    Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH
    J Biol Chem, 2020 Feb 14, 295(7): 1769-1780 | PMID: 31915252 | PMCID: PMC7029113
    Citations: | AltScore: 9.45
  7. Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
    Mau T, O'Brien M, Ghosh AK, Miller RA, Yung R
    J Gerontol A Biol Sci Med Sci, 2020 Jan 1, 75(1): 89-98 | PMID: 31353414 | PMCID: PMC6909899
    Citations: 1 | AltScore: 5.35
  8. Association of Physical Function With Driving Space and Crashes Among Older Adults.
    Ng LS, Guralnik JM, Man C, DiGuiseppi C, Strogatz D, Eby DW, Ryan LH, Molnar LJ, Betz ME, Hill L, Li G, Crowe CL, Mielenz TJ
    Gerontologist, 2020 Jan 24, 60(1): 69-79 | PMID: 30624694
    Citations: 1 | AltScore: 2.35
  9. Multiple Chronic Conditions in Spousal Caregivers of Older Adults With Functional Disability: Associations With Caregiving Difficulties and Gains.
    Polenick CA, Leggett AN, Webster NJ, Han BH, Zarit SH, Piette JD
    J Gerontol B Psychol Sci Soc Sci, 2020 Jan 1, 75(1): 160-172 | PMID: 29029293 | PMCID: PMC6909432
    Citations: 4 | AltScore: 18.686
  10. A novel geriatric assessment tool that predicts postoperative complications in older adults with cancer.
    Pollock Y, Chan CL, Hall K, Englesbe M, Diehl KM, Min L
    J Geriatr Oncol, 2020 Jun, 11(5): 866-872 | PMID: 31699673 | PMCID: PMC7196495
    Citations: | AltScore: 0.25
  11. Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin.
    Reid JJ, Linden MA, Peelor FF, Miller RA, Hamilton KL, Miller BF
    J Gerontol A Biol Sci Med Sci, 2020 Jan 1, 75(1): 40-49 | PMID: 30864661 | PMCID: PMC7175973
    Citations: 1 | AltScore: 3.6
  12. Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity.
    Varghese M, Griffin C, McKernan K, Eter L, Abrishami S, Singer K
    Aging (Albany NY), 2020 Jan 26, 12(2): 1725-1746 | PMID: 31983693 | PMCID: PMC7053605
    Citations: | AltScore: NA
  13. Is social capital protective against hospital readmissions?
    Zlotnick H, Hoffman GJ, Nuliyalu U, Engler TA, Langa KM, Ryan AM
    BMC Health Serv Res, 2020 Mar 24, 20(1): 248 | PMID: 32209077 | PMCID: PMC7092426
    Citations: | AltScore: 8.5
  1. Preventing Early Renal Loss in Diabetes (PERL) Study: A Randomized Double-Blinded Trial of Allopurinol-Rationale, Design, and Baseline Data.
    Afkarian M, Polsky S, Parsa A, Aronson R, Caramori ML, Cherney DZ, Crandall JP, de Boer IH, Elliott TG, Galecki AT, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Lingvay I, Maahs DM, McGill JB, Molitch ME, Perkins BA, Pop-Busui R, Pragnell M, Rosas SE, Rossing P, Senior P, Sigal RJ, Spino C, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, Doria A, PERL Study Group.
    Diabetes Care, 2019 Aug, 42(8): 1454-1463 | PMID: 31186299 | PMCID: PMC6647051
    Citations: 4 | AltScore: 13.75
  2. Comparison of Treadmill Trip-Like Training Versus Tai Chi to Improve Reactive Balance Among Independent Older Adult Residents of Senior Housing: A Pilot Controlled Trial.
    Aviles J, Allin LJ, Alexander NB, Van Mullekom J, Nussbaum MA, Madigan ML
    J Gerontol A Biol Sci Med Sci, 2019 Aug 16, 74(9): 1497-1503 | PMID: 30668636 | PMCID: PMC6696709
    Citations: 1 | AltScore: 3.6
  3. Vibrotactile display design: Quantifying the importance of age and various factors on reaction times.
    Bao T, Su L, Kinnaird C, Kabeto M, Shull PB, Sienko KH
    PLoS One, 2019, 14(8): e0219737 | PMID: 31398207 | PMCID: PMC6688825
    Citations: | AltScore: 1.25
  4. Chronic Stress and Negative Marital Quality Among Older Couples: Associations With Waist Circumference.
    Birditt KS, Newton NJ, Cranford JA, Webster NJ
    J Gerontol B Psychol Sci Soc Sci, 2019 Jan 10, 74(2): 318-328 | PMID: 27664418 | PMCID: PMC6327652
    Citations: 4 | AltScore: 108.05
  5. Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions.
    Carlozzi NE, Boileau NR, Murphy SL, Braley TJ, Kratz AL
    J Health Psychol, 2019 Sep 18 1359105319877448 | PMID: 31530191 | PMCID: PMC7078014
    Citations: | AltScore: 0.5
  6. Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury.
    Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, Lee JH
    Cell Discov, 2019, 5: 60 | PMID: 31754457 | PMCID: PMC6868011
    Citations: | AltScore: 0.25
  7. The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic ? cells and adipocytes.
    Corsa CAS, Pearson GL, Renberg A, Askar MM, Vozheiko T, MacDougald OA, Soleimanpour SA
    J Biol Chem, 2019 May 3, 294(18): 7296-7307 | PMID: 30877201 | PMCID: PMC6509499
    Citations: 3 | AltScore: 1.25
  8. Vision Impairment and Receipt of Eye Care Among Older Adults in Low- and Middle-Income Countries.
    Ehrlich JR, Stagg BC, Andrews C, Kumagai A, Musch DC
    JAMA Ophthalmol, 2019 Feb 1, 137(2): 146-158 | PMID: 30477016 | PMCID: PMC6440432
    Citations: 4 | AltScore: 9.45
  9. Naturally occurring osteoarthritis in male mice with an extended lifespan.
    Ewart D, Harper L, Gravely A, Miller RA, Carlson CS, Loeser RF
    Connect Tissue Res, 2020 Jan, 61(1): 95-103 | PMID: 31530037 | PMCID: PMC6884676
    Citations: | AltScore: 1
  10. Dual-Physician Households: Strategies for the 21st Century.
    Ferrante L, Mody L
    JAMA, 2019 Jun 11, 321(22): 2161-2162 | PMID: 31074762
    Citations: 2 | AltScore: 197
  11. Challenges of Dual-Physician Couples-Reply.
    Ferrante L, Mody L
    JAMA, 2019 Oct 15, 322(15): 1520 | PMID: 31613345
    Citations: | AltScore: NA
  12. 17-a estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males.
    Garratt M, Leander D, Pifer K, Bower B, Herrera JJ, Day SM, Fiehn O, Brooks SV, Miller RA
    Aging Cell, 2019 Apr, 18(2): e12920 | PMID: 30740872 | PMCID: PMC6413653
    Citations: 3 | AltScore: 6.7
  13. Adipose Tissue Senescence and Inflammation in Aging is Reversed by the Young Milieu.
    Ghosh AK, O'Brien M, Mau T, Qi N, Yung R
    J Gerontol A Biol Sci Med Sci, 2019 Oct 4, 74(11): 1709-1715 | PMID: 30590424 | PMCID: PMC6777079
    Citations: 4 | AltScore: 25.908
  14. Indwelling urethral versus suprapubic catheters in nursing home residents: determining the safest option for long-term use.
    Gibson KE, Neill S, Tuma E, Meddings J, Mody L
    J Hosp Infect, 2019 Jun, 102(2): 219-225 | PMID: 30056015 | PMCID: PMC6348043
    Citations: | AltScore: NA
  15. Acarbose improves health and lifespan in aging HET3 mice.
    Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA
    Aging Cell, 2019 Apr, 18(2): e12898 | PMID: 30688027 | PMCID: PMC6413665
    Citations: 6 | AltScore: 59.8
  16. Predictors of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci co-colonization among nursing facility patients.
    Heinze K, Kabeto M, Martin ET, Cassone M, Hicks L, Mody L
    Am J Infect Control, 2019 Apr, 47(4): 415-420 | PMID: 30502107 | PMCID: PMC6443432
    Citations: 2 | AltScore: 10.75
  17. Role of Post-Acute Care in Readmissions for Preexisting Healthcare-Associated Infections.
    Hoffman GJ, Min LC, Liu H, Marciniak DJ, Mody L
    J Am Geriatr Soc, 2020 Feb, 68(2): 370-378 | PMID: 31644835
    Citations: | AltScore: 123.55
  18. Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.
    Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R
    J Am Geriatr Soc, 2019 Mar, 67(3): 428-433 | PMID: 30693953 | PMCID: PMC6403012
    Citations: 1 | AltScore: 41.8
  19. The Church Challenge: A community-based multilevel cluster randomized controlled trial to improve blood pressure and wellness in African American churches in Flint, Michigan.
    Johnson-Lawrence V, Bailey S, Sanders PE, Sneed R, Angel-Vincent A, Brewer A, Key K, Lewis EY, Johnson JE
    Contemp Clin Trials Commun, 2019 Jun, 14: 100329 | PMID: 30886933 | PMCID: PMC6402374
    Citations: | AltScore: 2.75
  20. Probing short-latency cortical inhibition in the visual cortex with transcranial magnetic stimulation: A reliability study.
    Khammash D, Simmonite M, Polk TA, Taylor SF, Meehan SK
    Brain Stimul, 2019 May - Jun, 12(3): 702-704 | PMID: 30700394 | PMCID: PMC6486866
    Citations: 1 | AltScore: 0.5
  21. Characterising potential bone scan overuse amongst men treated with radical prostatectomy.
    Kirk PS, Borza T, Caram MEV, Shumway DA, Makarov DV, Burns JA, Shelton JB, Leppert JT, Chapman C, Chang M, Hollenbeck BK, Skolarus TA
    BJU Int, 2019 Jul, 124(1): 55-61 | PMID: 30246937 | PMCID: PMC6431565
    Citations: 1 | AltScore: NA
  22. Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans.
    Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Cushman M, McClure LA, Safford MM, Wadley VG
    Hypertension, 2019 Feb, 73(2): 310-318 | PMID: 30624986 | PMCID: PMC6450556
    Citations: 2 | AltScore: 48.4
  23. Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity.
    Li R, Huang Y, Semple I, Kim M, Zhang Z, Lee JH
    Am J Physiol Heart Circ Physiol, 2019 Jul 1, 317(1): H39-H48 | PMID: 31026186 | PMCID: PMC6692737
    Citations: 2 | AltScore: 1.25
  24. Bacteria Detected in both Urine and Open Wounds in Nursing Home Residents: a Pilot Study.
    Libertucci J, Bassis CM, Cassone M, Gibson K, Lansing B, Mody L, Young VB, Meddings J
    mSphere, 2019 Aug 28, 4(4):
    pii: e00463-19. | PMID: 31462413 | PMCID: PMC6714893
    Citations: | AltScore: 11.9
  25. Can Hearing Aids Delay Time to Diagnosis of Dementia, Depression, or Falls in Older Adults?
    Mahmoudi E, Basu T, Langa K, McKee MM, Zazove P, Alexander N, Kamdar N
    J Am Geriatr Soc, 2019 Nov, 67(11): 2362-2369 | PMID: 31486068
    Citations: 1 | AltScore: 320.92
  26. Technique development and measurement of cross-sectional area of the pubovisceral muscle on MRI scans of living women.
    Masteling M, Ashton-Miller JA, DeLancey JOL
    Int Urogynecol J, 2019 Aug, 30(8): 1305-1312 | PMID: 29974138 | PMCID: PMC6320718
    Citations: | AltScore: NA
  27. Predicting Risk of Potentially Preventable Hospitalization in Older Adults with Dementia.
    Maust DT, Kim HM, Chiang C, Langa KM, Kales HC
    J Am Geriatr Soc, 2019 Oct, 67(10): 2077-2084 | PMID: 31211418 | PMCID: PMC6896207
    Citations: | AltScore: 10.05
  28. Perception of Dementia Risk and Preventive Actions Among US Adults Aged 50 to 64 Years.
    Maust DT, Solway E, Langa KM, Kullgren JT, Kirch M, Singer DC, Malani P
    JAMA Neurol, 2019 Nov 15 | PMID: 31730178 | PMCID: PMC6865327
    Citations: | AltScore: 605.908
  29. Glycine supplementation extends lifespan of male and female mice.
    Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R
    Aging Cell, 2019 Jun, 18(3): e12953 | PMID: 30916479 | PMCID: PMC6516426
    Citations: 4 | AltScore: 35.108
  30. Measurement of Fall Injury With Health Care System Data and Assessment of Inclusiveness and Validity of Measurement Models.
    Min L, Tinetti M, Langa KM, Ha J, Alexander N, Hoffman GJ
    JAMA Netw Open, 2019 Aug 2, 2(8): e199679 | PMID: 31433480 | PMCID: PMC6707014
    Citations: 1 | AltScore: 8.7
  31. 11-Oxygenated C19 Steroids Do Not Decline With Age in Women.
    Nanba AT, Rege J, Ren J, Auchus RJ, Rainey WE, Turcu AF
    J Clin Endocrinol Metab, 2019 Jul 1, 104(7): 2615-2622 | PMID: 30753518 | PMCID: PMC6525564
    Citations: 6 | AltScore: 5.1
  32. The effects of five sessions of continuous theta burst stimulation over contralesional sensorimotor cortex paired with paretic skilled motor practice in people with chronic stroke.
    Neva JL, Brown KE, Wadden KP, Mang CS, Borich MR, Meehan SK, Boyd LA
    Restor Neurol Neurosci, 2019, 37(3): 273-290 | PMID: 31227676
    Citations: | AltScore: NA
  33. Cellular energetics and mitochondrial uncoupling in canine aging.
    Nicholatos JW, Robinette TM, Tata SVP, Yordy JD, Francisco AB, Platov M, Yeh TK, Ilkayeva OR, Huynh FK, Dokukin M, Volkov D, Weinstein MA, Boyko AR, Miller RA, Sokolov I, Hirschey MD, Libert S
    Geroscience, 2019 Apr, 41(2): 229-242 | PMID: 30937823 | PMCID: PMC6544733
    Citations: | AltScore: 25.9
  34. Reconstruction of body motion during self-reported losses of balance in community-dwelling older adults.
    Ojeda LV, Adamczyk PG, Rebula JR, Nyquist LV, Strasburg DM, Alexander NB
    Med Eng Phys, 2019 Feb, 64: 86-92 | PMID: 30581048 | PMCID: PMC6398340
    Citations: 1 | AltScore: NA
  35. Predictors of Secondary Role Strains Among Spousal Caregivers of Older Adults With Functional Disability.
    Polenick CA, DePasquale N
    Gerontologist, 2019 May 17, 59(3): 486-498 | PMID: 29325105 | PMCID: PMC6784276
    Citations: 2 | AltScore: 1
  36. Aging and Postintensive Care Syndrome- Family: A Critical Need for Geriatric Psychiatry.
    Serrano P, Kheir YNP, Wang S, Khan S, Scheunemann L, Khan B
    Am J Geriatr Psychiatry, 2019 Apr, 27(4): 446-454 | PMID: 30595492 | PMCID: PMC6431265
    Citations: | AltScore: 10.5
  37. Variations in Risk of End-Stage Renal Disease and Risk of Mortality in an International Study of Patients With Type 1 Diabetes and Advanced Nephropathy.
    Skupien J, Smiles AM, Valo E, Ahluwalia TS, Gyorgy B, Sandholm N, Croall S, Lajer M, McDonnell K, Forsblom C, Harjutsalo V, Marre M, Galecki AT, Tregouet DA, Wu CY, Mychaleckyj JC, Nickerson H, Pragnell M, Rich SS, Pezzolesi MG, Hadjadj S, Rossing P, Groop PH, Krolewski AS
    Diabetes Care, 2019 Jan, 42(1): 93-101 | PMID: 30455333 | PMCID: PMC6300701
    Citations: 1 | AltScore: 7.9
  38. Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice.
    Smith BJ, Miller RA, Ericsson AC, Harrison DC, Strong R, Schmidt TM
    BMC Microbiol, 2019 Jun 13, 19(1): 130 | PMID: 31195972 | PMCID: PMC6567620
    Citations: 5 | AltScore: 7.35
  39. Aging effects on pelvic floor support: a pilot study comparing young versus older nulliparous women.
    Swenson CW, Masteling M, DeLancey JO, Nandikanti L, Schmidt P, Chen L
    Int Urogynecol J, 2020 Mar, 31(3): 535-543 | PMID: 31388719
    Citations: | AltScore: 1.25
  40. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension.
    Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, Khaitovich P, Clish CB, Miller RA, Gladyshev VN
    Cell Metab, 2019 Sep 3, 30(3): 573-593.e8 | PMID: 31353263 | PMCID: PMC6907080
    Citations: 3 | AltScore: 158.544
  41. Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity.
    Varghese M, Griffin C, McKernan K, Eter L, Lanzetta N, Agarwal D, Abrishami S, Singer K
    Endocrinology, 2019 Feb 1, 160(2): 293-312 | PMID: 30544158 | PMCID: PMC6330175
    Citations: 7 | AltScore: 4.2
  42. Social Networks and Physical Activity in Senior Housing: A Pilot Feasibility Study.
    Webster NJ, Antonucci TC, Alexander NB
    Ethn Dis, 2019, 29(Suppl 1): 201-208 | PMID: 30906170 | PMCID: PMC6428167
    Citations: | AltScore: 0.25
  43. Physical Functioning Decline and Mortality in Older Adults With Multimorbidity: Joint Modeling of Longitudinal and Survival Data.
    Wei MY, Kabeto MU, Galecki AT, Langa KM
    J Gerontol A Biol Sci Med Sci, 2019 Jan 16, 74(2): 226-232 | PMID: 29529179 | PMCID: PMC6599282
    Citations: 6 | AltScore: 79.78
  44. The Association Between Differing Grip Strength Measures and Mortality and Cerebrovascular Event in Older Adults: National Health and Aging Trends Study.
    Whitney DG, Peterson MD
    Front Physiol, 2018, 9: 1871 | PMID: 30666214 | PMCID: PMC6330303
    Citations: 1 | AltScore: 2.85
  45. Trajectories of major depression in middle-aged and older adults: A population-based study.
    Xiang X, Cheng J
    Int J Geriatr Psychiatry, 2019 Oct, 34(10): 1506-1514 | PMID: 31179582 | PMCID: PMC6742519
    Citations: 1 | AltScore: 14
  46. Perceptions and practice behaviors regarding late-life depression among private duty home care workers: a mixed-methods study.
    Xiang X, Cheng J, Zuverink A, Wang X
    Aging Ment Health, 2019 Jul 4 1-8 | PMID: 31271041 | PMCID: PMC6942236
    Citations: | AltScore: NA

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