UNIVERSITY OF MICHIGAN
Claude D. Pepper Older Americans Independence Center

Principal Investigator    Raymond Yung, M.D.  734-647-9746  ryung@umich.edu
Program Administrator    Stephanie Gatica, B.A.  734-763-1118  sgatica@umich.edu
       
CENTER DESCRIPTION

Funded by the NIA as the nations first Geriatric Research and Training Center in 1989, the University of Michigan (UM) Pepper Center has evolved to meet the objectives of the OAIC program with successful competing renewals as an OAIC in 1994, 1999, 2004, 2009, 2015, and 2020. Thus, our Center is completing its 31st consecutive year of operation in 2020. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults.   Drawing on the large base of research currently underway in the fields of geriatrics and gerontology at UM, the UM Pepper Center fosters collaborative multidisciplinary research to integrate basic science, clinical science, and health services research relevant to the health care problems of older adults. The UM Pepper Center grant supports important research activities of the UM Geriatrics Center. Founded in 1987, the Geriatrics Center is the umbrella organization for geriatrics research, education, and patient care at the University of Michigan.

The specific goals of the UM Pepper Center are:

1.    To support research that will improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status.

2.    To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status.

3.    To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus.

4.    Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus.

5.    Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center’s research focus.

Faculty from the following UM Schools and Institutes are involved: the Institute of Gerontology, School of Public Health, Institute for Social Research, Medical School, College of Engineering, School of Nursing, School of Social Work, and College of Literature, Science, and the Arts. As of 2018 there were 89 active NIA grants at the UM with over $60 million/year of total costs. The UM OAIC’s faculty participant data base includes a total of 239 current UM faculty who have 221 current external grants relevant to the UM Pepper Center’s focus totaling over $57 million/year direct costs.


CORES
Leadership and Administrative Core (LAC)
Leader 1:    Raymond Yung, MD   ryung@med.umich.edu
Leader 2:    Lona Mody, MD, MSc   lonamody@umich.edu

A well-defined and effective Leadership Administrative Core (LAC) that supports the rich activities of the OAIC is already in place. The faculty and staff in the LAC have proven leadership and administrative skills. The LAC will foster critical interactions among the OAIC Program Director, the OAIC Core Directors/Co-Directors and the leadership structure of the Institution as a whole. These linkages are fostered by the proven administrative structure, which requires meetings of the OAIC leadership on a regular and ongoing basis, and of key advisory committees: the UM Geriatrics Center’s Research Operating Committee (ROC) and the OAIC External Advisory Board (EAB). The ROC, led by two fellowship-trained geriatricians/physician scientists (Yung, Mody) with complementary expertise and research interests, provides strategic planning, coordination and oversight for all OAIC activities. The membership of the ROC includes the LAC Leader and Co-Leader, the former OAIC Director, the ten other OAIC Core Directors/Co-Directors, and Geriatrics Center administrative leaders.



Research Education Component (REC)
Leader 1:    Neil B. Alexander, MD   nalexand@med.umich.edu
Leader 2:    Lillian Min, MD, MSHS   lmin@umich.edu
Leader 3:    Carrie Karvonen-Gutierrez   ckarvone@umich.edu
The REC is a component of the Claude D. Pepper Older Americans Independence Center, funded by the National Institute on Aging. The primary goal of the Research Education Core is to recruit, select, support, mentor, and train junior faculty to become independent investigators in aging-related research and academic leaders in geriatrics and gerontology within their respective disciplines. The REC focuses on stimulating the translation between basic and clinical research across the spectrum of its training activities, including the annual research education core retreat(link is external). To this end it serves a critical function in supporting the overall OAIC focus by training the next generation of investigators whose research will lead to an improved understanding of the predictors and modulators of the aging phenotype.

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Lona Mody, MD   lonamody@med.umich.edu
Leader 2:    Daniel R. Goldstein, MD   drgolds@umich.edu

The goal of the Pilot and Exploratory Studies Core is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme:

“To improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status”

The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research.



Biomechanics
Leader 1:    James Ashton-Miller, PhD   jaam@umich.edu
Leader 2:    Neil Alexander, MD   nalexand@umich.edu

The Biomechanics Core provides an array of techniques and equipment for the precise experimental quantification of physical functioning of healthy and frail elders in order to investigate attributes of the aging phenotype. It also supplies support for theoretical investigations in the form of computer simulation models to analyze the elements of those functional abilities and to establish the major determinants of abilities to perform motor acts in an effective manner. The Core is physically based in the Biomechanics Research Laboratory(link is external) (directed by Dr. Ashton-Miller) and the Mobility Research Center(link is external) (directed by Dr. Alexander).

Physical disabilities are epidemic in the elderly. Whatever the underlying pathologies, these disabilities express themselves in biomechanical terms: reduced muscular strengths and rates of developing strengths, limited ranges and speeds of motion, reduced afferent feedback, inappropriate body segment coordination patterns, difficulty with balance and fall arrests, and even impaired pelvic floor and continence system function.

The Biomechanics Core will contribute to the development of academic leaders in geriatrics by helping interested faculty and their fellows to analyze a range of geriatric problems through biomechanical research techniques. Thus, it will train them through directed study involving background reviews, hypothesis generation, interdisciplinary pilot research projects, and data analysis and interpretation to examine issues adversely affecting the physical abilities of the elderly.



Core Facility for Aged Rodents (CFAR)
Leader 1:    Richard Miller, MD, PhD   millerr@umich.edu

The Core Facility for Aged Rodents, CFAR, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR serves the needs of Pepper Center investigators through four Specific Aims.

  1. CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease.
  2. CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock; (b) calorically restricted UM-HET3 mice; and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pit1 dw mutation. Mice from these colonies will be provided to faculty members working on Pilot Studies Exploratory Core (PESC) and Research Career Development Core (RCDC) research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds.
  3. CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new four-way cross suitable for studies of late-life hearing loss.


Design, Data, and Biostatistics Core (DDBC)
Leader 1:    Andrzej Galecki, PhD, MD   agalecki@umich.edu
Leader 2:    Julie Bynum, M.D., M.Ph.   bynumju@umich.edu
The Design, Data, and Biostatistics Core (DDBC) will provide technical support and training of investigators developing or performing intervention and other geriatric research projects examining the aging phenotype and outcomes research. It will also develop new instruments, methodologies, and data archives to enable future studies. Thus the DDBC will both address techniques for appropriate design and execution of current experiments and set the foundation for future research studies. Building on our experience with the UM Pepper Center, the DDBC will address the needs of OAIC investigators, and especially junior investigators, for assistance in the design of intervention experiments, and the collection, maintenance, analysis, and interpretation of their data.

Human Subjects and Assessment (HSAC)
Leader 1:    Raymond Yung, MD   ryung@med.umich.edu
Leader 2:    Kenneth Langa, MD, PhD   klanga@umich.edu

The Human Subjects and Assessment Core (HSAC) supports activities involving human subjects at the University of Michigan Claude D. Pepper Center.  It has four specific aims:

  • HSAC will establish, maintain, and facilitate access to human subjects and related data sets.
  • HSAC will expand, promote and facilitate access to minority human subjects through collaborative linkages with the Wayne State University Institute of Gerontology (WSU IoG).
  • HSAC aims to provide selected efficient physical health measures, which will complement our existing collection of self-reported health, health care utilization, and psychosocial measures in subject selection.
  • HSAC will provide training and consultation to investigators on issues related to (a) recruitment and retention of human subjects, and (b) measurement of quality of life and psychosocial factors closely linked with aging phenotype.


CAREER DEVELOPMENT
REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications
 
Jiha Lee, MD, MHS
Assistant Professor / University of Michigan
Assistant Professor
2019-2021  0 (0 1st/Sr)
Xiaoling Xiang
Assistant Professor / University of Michigan School of Social Work
Acceptability of home care worker-supported, technology-based treatment for late-life depression in non-skilled home care
  • Blue Cross Blue Shield of Michigan Foundation (#02748.II) Happy@Home: Training personal care aides to administer online therapy for depression in homecare seniors Role: Principal Investigator Direct cost: $65,000 Dates: 04/01/2019-09/30/2020
  • Michigan-HHS/DHHS-Medicare/Medicaid (E20202768-00) MIP: Implementation of technology-assisted psychotherapy in non-skilled home care. Role: Principal Investigator Direct cost: $36,872 Dates: 10/01/2019-09/30/2020
  • Michigan-HHS/DHHS-Medicare/Medicaid (E20193400-00) MIP: Implementation of technology-assisted psychotherapy in non-skilled home care. Role: Principal Investigator Direct cost: $28,128 Dates: 04/01/2019-09/30/2019
  • University of Michigan Mcubed Diamond Cube (#9501) Improving Quality of Care for Memory Loss Patients Role: Co-Investigator (PI: D. Maust) Direct cost: $60,000 Dates: 06/01/2019-05/31/2020

2019-2021  57 (31 1st/Sr)

Past Scholars
Marco Cassone, MD, PhD, University of Michigan, Geriatrics & Palliative Medicine (2018-2020)
Jaclynn Hawkins, University of Michigan School of Social Work (2019-2020)

PILOT/EXPLORATORY PROJECTS (12 Pilot Projects Listed)
1. Project Title: Type 2 Diabetes Self-Management in Older African American Men: A Peer Leader Pilot Intervention
  Leader: Jaclyn Hawkins
 

PESC Year 16 (7/1/20-6/30/21)

The overall objectives of the proposed study are to: (1) systematically adapt and preliminarily validate a peer leader type 2 diabetes (T2D) self-management support intervention designed to improve diabetes-related lifestyle and self-management behaviors in older Black men with T2D and (2) to evaluate the relevance and acceptability of the adapted intervention in preparation for subsequent trials.

 
2. Project Title: De-escalation of bDMARDS in Rheumatoid Arthritis in Older Adults with RA
  Leader: Jiha Lee
 

PESC Year 16 (7/1/20-6/30/21)

The overarching goal of this project is to test the feasibility of identifying de-escalation of bDMARDs using Medicare claims data necessary for me to study drivers of variation in de-escalation of bDMARDs among older adults with RA.  

 
3. Project Title: Home-delivered Meals to Prevent Recurrent Hepatic Encephalopathy in Older Adults
  Leader: Elliot Tapper
 

PESC Year 16 (7/1/20-6/30/21)

The goal is to determine if home delivered meal programs reduce the recurrent risk of hepatic encephalophaty

 
4. Project Title: Pathway to De-escalation: Characterizing antibiotic prescribing cascades in older adults
  Leader: Valerie Vaughn
 

PESC Year 16 (7/1/20-6/30/21)

The goal is to describe the full phenotype of non-specific signs and symptoms in older adults entering into the antibiotic prescribing cascade and identify risk factors associated with such symptoms.

 
5. Project Title: Probing the relationship of the neuromuscular junction on muscle stem cells in aging
  Leader: Carlos Aguilar
 

PESC Year 15 (7/1/19-6/30/20)

 
6. Project Title: Exploring the impact of neuronal vulnerability to aging-related disorders on spatial learning in C. elegans model organism
  Leader: Daniela Ponce-Balbuena
 

PESC Year 15 (7/1/19-6/30/20)

 
7. Project Title: Ectonucleotidase modulation of age determined vascular calcification and fibrosis
  Leader: Nadia Sutton
 

PESC Year 15 (7/1/19-6/30/20)

 
8. Project Title: Diet-induced cellular senescence and thermogenic fat function
  Leader: Jun Wu
 

PESC Year 15 (7/1/19-6/30/20)

 
9. Project Title: Exploring the impact of neuronal vulnerability to aging-related disorders on spatial learning in C. elegans model organism
  Leader: Eleni Gourgou
 

PESC Year 15 (7/1/19-6/30/20)

 
10. Project Title: Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR): Pilot Trial
  Leader: Phillip Vlisides
 

PESC Year 15 (7/1/19-6/30/20)

 
11. Project Title: Towards a Culturally Responsive Intervention for Black Caregivers of Persons with Dementia
  Leader: Sheria Robinson-Lane
 

PESC Year 15 (7/1/19-6/30/20)

 
12. Project Title: How metabolic profiles change with aging and are affected by protein aggregation
  Leader: Matthias Truttman
 

PESC Year 15 (7/1/19-6/30/20)

 
DEVELOPMENT PROJECTS (2 Development Projects Listed)
1. Project Title: Design, Data and Biostatistics Core Development Project
  Leader: Andrzej Galecki; Julie Bynum
  Core(s):
 

Software tools for separable covariance models in multivariate longitudinal data/repeated measures analysis.

 
2. Project Title: Biomechanics Core Development Project
  Leader: James Ashton-Miller
  Core(s):
 

Develop a real time sensor to detect hyponatremia

 
RESEARCH (0 Projects Listed)
PUBLICATIONS
2021
 
2020
  1. The Relationship of Loneliness to End-of-Life Experience in Older Americans: A Cohort Study.
    Abedini NC, Choi H, Wei MY, Langa KM, Chopra V
    J Am Geriatr Soc, 2020 Mar 3, 68(5): 1064-1071
    https://doi.org/10.1111/jgs.16354 | PMID: 32128789 | PMCID: PMC7234919
    Citations: 1 | AltScore: 46.95
  2. Vision impairment and depression among older adults in low- and middle-income countries.
    Abou-Hanna JJ, Leggett AN, Andrews CA, Ehrlich JR
    Int J Geriatr Psychiatry, 2020 Aug 4, 36(1): 64-75
    https://doi.org/10.1002/gps.5394 | PMID: 32749746
    Citations: | AltScore: NA
  3. Comparison of anorectal function measured using wearable digital manometry and a high resolution manometry system.
    Attari A, Chey WD, Baker JR, Ashton-Miller JA
    PLoS One, 2020, 15(9): e0228761
    https://doi.org/10.1371/journal.pone.0228761 | PMID: 32991595 | PMCID: PMC7523952
    Citations: | AltScore: NA
  4. Improvement in trunk kinematics after treadmill-based reactive balance training among older adults is strongly associated with trunk kinematics before training.
    Aviles J, Wright DL, Allin LJ, Alexander NB, Madigan ML
    J Biomech, 2020 Dec 2, 113: 110112
    https://doi.org/10.1016/j.jbiomech.2020.110112 | PMID: 33190053 | PMCID: PMC7736255
    Citations: | AltScore: NA
  5. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.
    Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P, STRIDE Trial Investigators.
    N Engl J Med, 2020 Jul 9, 383(2): 129-140
    https://doi.org/10.1056/NEJMoa2002183 | PMID: 32640131 | PMCID: PMC7421468
    Citations: 1 | AltScore: 272.596
  6. So Close and Yet So Irritating: Negative Relations and Implications for Well-being by Age and Closeness.
    Birditt KS, Sherman CW, Polenick CA, Becker L, Webster NJ, Ajrouch KJ, Antonucci TC
    J Gerontol B Psychol Sci Soc Sci, 2020 Jan 14, 75(2): 327-337
    https://doi.org/10.1093/geronb/gby038 | PMID: 29596623 | PMCID: PMC7179808
    Citations: 2 | AltScore: 9.08
  7. Age-associated arterial calcification: the current pursuit of aggravating and mitigating factors.
    Chakrabarti A, Goldstein DR, Sutton NR
    Curr Opin Lipidol, 2020 Oct, 31(5): 265-272
    https://doi.org/10.1097/MOL.0000000000000703 | PMID: 32773466
    Citations: | AltScore: 3.85
  8. Identifying predictors of upper extremity muscle elasticity with healthy aging.
    Chodock E, Hahn J, Setlock CA, Lipps DB
    J Biomech, 2020 Apr 16, 103: 109687
    https://doi.org/10.1016/j.jbiomech.2020.109687 | PMID: 32147243 | PMCID: PMC7168868
    Citations: 1 | AltScore: 4.45
  9. Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
    Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, Parsa A, Rossing P, Sigal RJ, Afkarian M, Aronson R, Caramori ML, Crandall JP, de Boer IH, Elliott TG, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Maahs DM, McGill JB, Molitch ME, Perkins BA, Polsky S, Pragnell M, Robiner WN, Rosas SE, Senior P, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, PERL Study Group.
    N Engl J Med, 2020 Jun 25, 382(26): 2493-2503
    https://doi.org/10.1056/NEJMoa1916624 | PMID: 32579810 | PMCID: PMC7375708
    Citations: 4 | AltScore: 313.41
  10. Several Roads Lead to Rome: Operationalizing Antibiotic Stewardship Programs in Nursing Homes.
    Furuno JP, Mody L
    J Am Geriatr Soc, 2020 Jan, 68(1): 11-14
    https://doi.org/10.1111/jgs.16279 | PMID: 31825520
    Citations: | AltScore: 8.8
  11. Trends in Antipsychotic and Mood Stabilizer Prescribing in Long-Term Care in the U.S.: 2011-2014.
    Gerlach LB, Kales HC, Kim HM, Bynum JPW, Chiang C, Strominger J, Maust DT
    J Am Med Dir Assoc, 2020 Nov, 21(11): 1629-1635.e8
    https://doi.org/10.1016/j.jamda.2020.05.039 | PMID: 32693995 | PMCID: PMC7641905
    Citations: | AltScore: 0.25
  12. Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.
    Gill TM, Bhasin S, Reuben DB, Latham NK, Araujo K, Ganz DA, Boult C, Wu AW, Magaziner J, Alexander N, Wallace RB, Miller ME, Travison TG, Greenspan SL, Gurwitz JH, Rich J, Volpi E, Waring SC, Manini TM, Min LC, Teresi J, Dykes PC, McMahon S, McGloin JM, Skokos EA, Charpentier P, Basaria S, Duncan PW, Storer TW, Gazarian P, Allore HG, Dziura J, Esserman D, Carnie MB, Hanson C, Ko F, Resnick NM, Wiggins J, Lu C, Meng C, Goehring L, Fagan M, Correa-de-Araujo R, Casteel C, Peduzzi P, Greene EJ
    J Am Geriatr Soc, 2020 Oct 9
    https://doi.org/10.1111/jgs.16854 | PMID: 33037632
    Citations: | AltScore: 3.6
  13. Optimizing Retention in a Pragmatic Trial of Community-Living Older Persons: The STRIDE Study.
    Gill TM, McGloin JM, Shelton A, Bianco LM, Skokos EA, Latham NK, Ganz DA, Nyquist LV, Wallace RB, Carnie MB, Dykes PC, Goehring LA, Doyle M, Charpentier PA, Greene EJ, Araujo KL
    J Am Geriatr Soc, 2020 Mar 25, 68(6): 1242-1249
    https://doi.org/10.1111/jgs.16356 | PMID: 32212395 | PMCID: PMC7707554
    Citations: 1 | AltScore: 6.2
  14. Contamination of Common Area and Rehabilitation Gym Environment with Multidrug-Resistant Organisms.
    Gontjes KJ, Gibson KE, Lansing B, Cassone M, Mody L
    J Am Geriatr Soc, 2020 Mar, 68(3): 478-485
    https://doi.org/10.1111/jgs.16284 | PMID: 31851386
    Citations: 1 | AltScore: 78.43
  15. Detection of Real-World Trips in At-Fall Risk Community Dwelling Older Adults Using Wearable Sensors.
    Handelzalts S, Alexander NB, Mastruserio N, Nyquist LV, Strasburg DM, Ojeda LV
    Front Med (Lausanne), 2020, 7: 514
    https://doi.org/10.3389/fmed.2020.00514 | PMID: 32984385 | PMCID: PMC7492551
    Citations: | AltScore: NA
  16. ResearchCOVID-19 Preparedness in Michigan Nursing Homes.
    Jones KM, Mantey J, Mills JP, Montoya A, Min L, Gibson K, Mody L
    J Am Geriatr Soc, 2020 May, 68(5): 937-939
    https://doi.org/10.1111/jgs.16490 | PMID: 32293023 | PMCID: PMC7262293
    Citations: 4 | AltScore: 96.45
  17. Sestrins are evolutionarily conserved mediators of exercise benefits.
    Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH
    Nat Commun, 2020 Jan 13, 11(1): 190
    https://doi.org/10.1038/s41467-019-13442-5 | PMID: 31929512 | PMCID: PMC6955242
    Citations: 8 | AltScore: 564.378
  18. Physical and Functional Impairment Among Older Adults With a History of Traumatic Brain Injury.
    Kornblith ES, Langa KM, Yaffe K, Gardner RC
    J Head Trauma Rehabil, 2020 Jul/Aug, 35(4): E320-E329
    https://doi.org/10.1097/HTR.0000000000000552 | PMID: 31996604 | PMCID: PMC7335322
    Citations: | AltScore: 5.55
  19. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
    Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH
    J Biol Chem, 2020 Feb 14, 295(7): 1769-1780
    https://doi.org/10.1074/jbc.RA119.010857 | PMID: 31915252 | PMCID: PMC7029113
    Citations: 1 | AltScore: 9.45
  20. Mild cognitive impairment and receipt of procedures for acute ischemic stroke in older adults.
    Levine DA, Galecki A, Kabeto M, Nallamothu BK, Zahuranec DB, Morgenstern LB, Lisabeth LD, Giordani B, Langa KM
    J Stroke Cerebrovasc Dis, 2020 Oct, 29(10): 105083
    https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.105083 | PMID: 32912555 | PMCID: PMC7490756
    Citations: | AltScore: NA
  21. Mild Cognitive Impairment and Receipt of Treatments for Acute Myocardial Infarction in Older Adults.
    Levine DA, Langa KM, Galecki A, Kabeto M, Morgenstern LB, Zahuranec DB, Giordani B, Lisabeth LD, Nallamothu BK
    J Gen Intern Med, 2020 Jan, 35(1): 28-35
    https://doi.org/10.1007/s11606-019-05155-8 | PMID: 31410812 | PMCID: PMC6957594
    Citations: 3 | AltScore: 78.03
  22. Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.
    Li X, Frazier JA, Spahiu E, McPherson M, Miller RA
    Aging (Albany NY), 2020 May 28, 12(10): 8766-8789
    https://doi.org/10.18632/aging.103380 | PMID: 32464603 | PMCID: PMC7288969
    Citations: | AltScore: 14.858
  23. Potentially Preventable Hospitalizations Among Older Adults: 2010-2014.
    Mahmoudi E, Kamdar N, Furgal A, Sen A, Zazove P, Bynum J
    Ann Fam Med, 2020 Nov, 18(6): 511-519
    https://doi.org/10.1370/afm.2605 | PMID: 33168679 | PMCID: PMC7708283
    Citations: | AltScore: 20.6
  24. Physical Activity and Falls Among a National Cohort of Older Veterans.
    Marciniak D, Alexander NB, Hoffman GJ
    J Appl Gerontol, 2020 Apr 10 733464820915807
    https://doi.org/10.1177/0733464820915807 | PMID: 32274955 | PMCID: PMC7554127
    Citations: | AltScore: 87.08
  25. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.
    Markworth JF, Brown LA, Lim E, Floyd C, Larouche J, Castor-Macias JA, Sugg KB, Sarver DC, Macpherson PC, Davis C, Aguilar CA, Maddipati KR, Brooks SV
    JCI Insight, 2020 Sep 17, 5(18):
    pii: 137713. https://doi.org/10.1172/jci.insight.137713 | PMID: 32750044 | PMCID: PMC7526543
    Citations: | AltScore: 18.05
  26. Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
    Mau T, O'Brien M, Ghosh AK, Miller RA, Yung R
    J Gerontol A Biol Sci Med Sci, 2020 Jan 1, 75(1): 89-98
    https://doi.org/10.1093/gerona/glz177 | PMID: 31353414 | PMCID: PMC6909899
    Citations: 2 | AltScore: 5.6
  27. Partnering with Local Hospitals and Public Health to Manage COVID-19 Outbreaks in Nursing Homes.
    Montoya A, Jenq G, Mills JP, Beal J, Diviney Chun E, Newton D, Gibson K, Mantey J, Hurst K, Jones K, Mody L
    J Am Geriatr Soc, 2020 Oct 9
    https://doi.org/10.1111/jgs.16869 | PMID: 33034039 | PMCID: PMC7675453
    Citations: | AltScore: 95.16
  28. Association of Physical Function With Driving Space and Crashes Among Older Adults.
    Ng LS, Guralnik JM, Man C, DiGuiseppi C, Strogatz D, Eby DW, Ryan LH, Molnar LJ, Betz ME, Hill L, Li G, Crowe CL, Mielenz TJ
    Gerontologist, 2020 Jan 24, 60(1): 69-79
    https://doi.org/10.1093/geront/gny178 | PMID: 30624694 | PMCID: PMC7317610
    Citations: 2 | AltScore: 2.35
  29. Evaluation of Racial Disparities in Hospice Use and End-of-Life Treatment Intensity in the REGARDS Cohort.
    Ornstein KA, Roth DL, Huang J, Levitan EB, Rhodes JD, Fabius CD, Safford MM, Sheehan OC
    JAMA Netw Open, 2020 Aug 3, 3(8): e2014639
    https://doi.org/10.1001/jamanetworkopen.2020.14639 | PMID: 32833020 | PMCID: PMC7445597
    Citations: | AltScore: 134
  30. Holistic Characterization of Single Hepatocyte Transcriptome Responses to High Fat Diet.
    Park SR, Cho CS, Xi J, Kang HM, Lee JH
    Am J Physiol Endocrinol Metab, 2020 Oct 26
    https://doi.org/10.1152/ajpendo.00391.2020 | PMID: 33103450
    Citations: 1 | AltScore: 10.25
  31. Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage.
    Park SR, Namkoong S, Friesen L, Cho CS, Zhang ZZ, Chen YC, Yoon E, Kim CH, Kwak H, Kang HM, Lee JH
    Cell Rep, 2020 Aug 25, 32(8): 108077
    https://doi.org/10.1016/j.celrep.2020.108077 | PMID: 32846134 | PMCID: PMC7486130
    Citations: 1 | AltScore: 79.946
  32. Multiple Chronic Conditions in Spousal Caregivers of Older Adults With Functional Disability: Associations With Caregiving Difficulties and Gains.
    Polenick CA, Leggett AN, Webster NJ, Han BH, Zarit SH, Piette JD
    J Gerontol B Psychol Sci Soc Sci, 2020 Jan 1, 75(1): 160-172
    https://doi.org/10.1093/geronb/gbx118 | PMID: 29029293 | PMCID: PMC6909432
    Citations: 7 | AltScore: 18.686
  33. A novel geriatric assessment tool that predicts postoperative complications in older adults with cancer.
    Pollock Y, Chan CL, Hall K, Englesbe M, Diehl KM, Min L
    J Geriatr Oncol, 2020 Jun, 11(5): 866-872
    https://doi.org/10.1016/j.jgo.2019.09.013 | PMID: 31699673 | PMCID: PMC7196495
    Citations: 1 | AltScore: 0.25
  34. Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin.
    Reid JJ, Linden MA, Peelor FF, Miller RA, Hamilton KL, Miller BF
    J Gerontol A Biol Sci Med Sci, 2020 Jan 1, 75(1): 40-49
    https://doi.org/10.1093/gerona/glz069 | PMID: 30864661 | PMCID: PMC7175973
    Citations: 3 | AltScore: 3.6
  35. Translational control in aging and neurodegeneration.
    Skariah G, Todd PK
    Wiley Interdiscip Rev RNA, 2020 Sep 20 e1628
    https://doi.org/10.1002/wrna.1628 | PMID: 32954679
    Citations: | AltScore: 27.4
  36. Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.
    Strong R, Miller RA, Bogue M, Fernandez E, Javors MA, Libert S, Marinez PA, Murphy MP, Musi N, Nelson JF, Petrascheck M, Reifsnyder P, Richardson A, Salmon AB, Macchiarini F, Harrison DE
    Aging Cell, 2020 Nov, 19(11): e13269
    https://doi.org/10.1111/acel.13269 | PMID: 33145977 | PMCID: PMC7681050
    Citations: | AltScore: 33.58
  37. Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity.
    Varghese M, Griffin C, McKernan K, Eter L, Abrishami S, Singer K
    Aging (Albany NY), 2020 Jan 26, 12(2): 1725-1746
    https://doi.org/10.18632/aging.102709 | PMID: 31983693 | PMCID: PMC7053605
    Citations: | AltScore: NA
  38. Investigating the birth-related caudal maternal pelvic floor muscle injury: The consequences of low cycle fatigue damage.
    Vila Pouca MCP, Parente MPL, Natal Jorge RM, Ashton-Miller JA
    J Mech Behav Biomed Mater, 2020 Oct, 110: 103956
    https://doi.org/10.1016/j.jmbbm.2020.103956 | PMID: 32957249
    Citations: | AltScore: NA
  39. Gut microbiota features on nursing home admission are associated with subsequent acquisition of antibiotic resistant organism colonization.
    Wang J, Cassone M, Gibson K, Lansing B, Mody L, Snitkin ES, Rao K
    Clin Infect Dis, 2020 Jun 1
    pii: ciaa662. https://doi.org/10.1093/cid/ciaa662 | PMID: 32478813
    Citations: | AltScore: 2.5
  40. Self-reported Vision Impairment and Subjective Well-being in Older Adults: A Longitudinal Mediation Analysis.
    Xiang X, Freedman VA, Shah K, Hu RX, Stagg BC, Ehrlich JR
    J Gerontol A Biol Sci Med Sci, 2020 Feb 14, 75(3): 589-595
    https://doi.org/10.1093/gerona/glz148 | PMID: 31169894 | PMCID: PMC7328199
    Citations: 2 | AltScore: 4.7
  41. Internet-delivered cognitive behavioral therapies for late-life depressive symptoms: a systematic review and meta-analysis.
    Xiang X, Wu S, Zuverink A, Tomasino KN, An R, Himle JA
    Aging Ment Health, 2020 Aug, 24(8): 1196-1206
    https://doi.org/10.1080/13607863.2019.1590309 | PMID: 30913898 | PMCID: PMC7529149
    Citations: 2 | AltScore: 3.75
  42. Is social capital protective against hospital readmissions?
    Zlotnick H, Hoffman GJ, Nuliyalu U, Engler TA, Langa KM, Ryan AM
    BMC Health Serv Res, 2020 Mar 24, 20(1): 248
    https://doi.org/10.1186/s12913-020-05092-x | PMID: 32209077 | PMCID: PMC7092426
    Citations: | AltScore: 8.5


EXTERNAL ADVISORY BOARD MEMBERS

Kenneth Schmader
Duke University
Serving since 2017 (4 years)

Nathan LaBrasseur
Mayo Clinic
Serving since 2017 (4 years)

Stephen Kritchevsky
Wake Forest University
Serving since 2017 (4 years)

Kenneth Covinsky
UCSF
Serving since 2020 (1 years)


RECOGNITION AND AWARDS (2020-2021)
Henry Paulson (2020)
  • 2016 elected Fellow in the American Association for the Advancement of Sciences
  • American Academy of Neurology Annual Movement Disorders Research Award, 2020
  • NINDS Landis 2020 Outstanding Mentor Award

MINORITY RESEARCH

General Brief Description of Minority Activities:

                                                                                                                                     

The following lists recent articles focusing on minority health and disparities authored by University of Michigan Pepper Center faculty and trainees.

 

1.    Akinyemi E, Watkins DC, Kavanagh J, Johnson-Lawrence V, Lynn S, Kales HC. A qualitative comparison of DSM depression criteria to language used by older church-going African-Americans. Aging Ment Health. 2018 Sep;22(9):1149-1155. doi: 10.1080/13607863.2017.1337717. Epub 2017 Jun 14. PMID: 28612654

2.    Allen JO, Watkins DC, Chatters L, Geronimus AT, Johnson-Lawrence V. Cortisol and Racial Health Disparities Affecting Black Men in Later Life: Evidence From MIDUS II. Am J Mens Health. 2019 Jul-Aug;13(4):1557988319870969. doi: 10.1177/1557988319870969. PMID: 31423887

3.    Allen JO, Watkins DC, Chatters L, Johnson-Lawrence V. Mechanisms of Racial Health Disparities: Evidence on Coping and Cortisol from MIDUS II. J Racial Ethn Health Disparities. 2020 Apr;7(2):207-216. doi: 10.1007/s40615-019-00648-y. Epub 2019 Nov 5. PMID: 31691170

4.    Briceño EM, Mehdipanah R, Gonzales X, Heeringa S, Levine DA, Langa KM, Garcia N, Longoria R, Morgenstern LB. Methods and Early Recruitment of a Community-Based Study of Cognitive Impairment Among Mexican Americans and Non-Hispanic Whites: The BASIC-Cognitive Study. J Alzheimers Dis. 2020;73(1):185-196. doi: 10.3233/JAD-190761. PMID: 31771059

5.    Briceño EM, Mehdipanah R, Gonzales XF, Langa KM, Levine DA, Garcia NM, Longoria R, Giordani BJ, Heeringa SG, Morgenstern LB. Culture and Diagnosis of MCI in Hispanics: A Literature Review. Arch Clin Neuropsych. 2019;34(7): 1239. doi:10.1093/arclin/acz029.06

6.    Briceño EM, Mehdipanah R, Gonzales XF, Langa KM, Levine DA, Garcia NM, Longoria R, Giordani BJ, Heeringa SG, Morgenstern LB. Neuropsychological assessment of mild cognitive impairment in Latinx adults: A scoping review. Neuropsychology. 2020 Jul;34(5):493-510. doi: 10.1037/neu0000628. Epub 2020 Apr 13. PMID: 32281811

7.    Choi H, Schoeni RF, Martin LG, Langa KM. Trends in the Prevalence and Disparity in Cognitive Limitations of Americans 55-69 Years Old. J Gerontol B Psychol Sci Soc Sci. 2018 Apr 16;73(suppl_1):S29-S37. PMCID: PMC6019031

8.    Davis MA, Guo C, Sol K, Langa KM, Nallamothu BK. Trends and Disparities in the Number of Self-reported Healthy Older Adults in the United States, 2000 to 2014. JAMA Intern Med. 2017 Nov 1;177(11):1683-1684. PMCID: PMC5753793

9.    Dean DAL, Griffith DM, McKissic SA, Cornish EK, Johnson-Lawrence V. Men on the Move-Nashville: Feasibility and Acceptability of a Technology-Enhanced Physical Activity Pilot Intervention for Overweight and Obese Middle and Older Age African American Men. Am J Mens Health. 2018 Jul;12(4):798-811. doi: 10.1177/1557988316644174. Epub 2016 Apr 19. PMID: 27099346

10.  Hawkins J, Mitchell J, Piatt G, Ellis D. Older African American Men's Perspectives on Factors That Influence Type 2 Diabetes Self-Management and Peer-Led Interventions. Geriatrics (Basel). 2018 Jul 6;3(3):38. doi: 10.3390/geriatrics3030038. PMID: 31011076 

11.  Hawkins J, Watkins D, Allen JO, Mitchell J. Identifying subgroups of Black, Hispanic and Asian men at increased risk for comorbid depression and overweight or obesity. Prev Med Rep. 2018 Oct 27;12:268-270. doi: 10.1016/j.pmedr.2018.10.022. eCollection 2018 Dec. PMID: 30406004 

12.  Hawkins JM. Type 2 Diabetes Self-Management in Non-Hispanic Black Men: A Current State of the Literature. Curr Diab Rep. 2019 Feb 11;19(3):10. doi: 10.1007/s11892-019-1131-8. PMID: 30741346

13.  Hazard Vallerand A, Hasenau SM, Robinson-Lane SG, Templin TN. Improving Functional Status in African Americans With Cancer Pain: A Randomized Clinical Trial. Oncol Nurs Forum. 2018 Mar 1;45(2):260-272. doi: 10.1188/18.ONF.260-272. PMID: 29466352

14.  Johnson-Lawrence V, Bailey S, Sanders PE, Sneed R, Angel-Vincent A, Brewer A, Key K, Lewis EY, Johnson JE. The Church Challenge: A community-based multilevel cluster randomized controlled trial to improve blood pressure and wellness in African American churches in Flint, Michigan. Contemp Clin Trials Commun. 2019 Feb 2;14:100329. doi: 10.1016/j.conctc.2019.100329. eCollection 2019 Jun. PMID: 30886933

15.  Johnson-Lawrence V, Scott JB, James SA. Education, perceived discrimination and risk for depression in a southern black cohort. Aging Ment Health. 2019 Aug 7:1-7. doi: 10.1080/13607863.2019.1647131. Online ahead of print. PMID: 31389255

16.  Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Cushman M, McClure LA, Safford MM, Wadley VG. Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans. Hypertension. 2019 Feb;73(2):310-318.  PMCID: PMC6450556

17.  Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Cushman M, McClure LA, Safford MM, Wadley VG. Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans. Hypertension. 2019 Feb;73(2):310-318. doi: 10.1161/HYPERTENSIONAHA.118.12062. PMID: 30624986

18.  Levine DA, Gross AL, Briceño EM, Tilton N, Kabeto MU, Hingtgen SM, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Elkind MSV, Manly JJ, Moran AE, Kulick ER, Gottesman RF, Walker KA, Yano Y, Gaskin DJ, Sidney S, Yaffe K, Sacco RL, Wright CB, Roger VL, Allen NB, Galecki AT. Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals. JAMA Neurol. 2020 Apr 13;77(7):1-10. doi: 10.1001/jamaneurol.2020.0568. Online ahead of print. PMID: 32282019

19.  Levine DA, Wadley VG, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Howard G, Howard VJ, Cushman M, Judd SE, Galecki AT. Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Stroke. 2018 Apr;49(4):987-994. Epub 2018 Mar 16. PMCID: PMC6419761.

20.  Levine DA, Wadley VG, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Howard G, Howard VJ, Cushman M, Judd SE, Galecki AT. Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke). Stroke. 2018 Apr;49(4):987-994. doi: 10.1161/STROKEAHA.117.018529. Epub 2018 Mar 16. PMID: 29581343

21.  McGrath R, Robinson-Lane SG, Peterson MD, Bailey RR, Vincent BM. Muscle Strength and Functional Limitations: Preserving Function in Older Mexican Americans. J Am Med Dir Assoc. 2018 May;19(5):391-398. doi: 10.1016/j.jamda.2017.12.011. Epub 2018 Jan 19. PMID: 29371128

22.  Mezuk B, Tarraf W, Johnson-Lawrence V, Ilardo J, Lichtenberg PA, Jackson JS. Analytic Training for Junior Investigators in Minority Aging Research: The Michigan Model. Gerontologist. 2020 Apr 30:gnaa001. doi: 10.1093/geront/gnaa001. Online ahead of print. PMID: 32352144

23.  Mitchell JA, Johnson-Lawrence V, Williams EG, Thorpe R Jr. Characterizing Mobility Limitations Among Older African American Men. J Natl Med Assoc. 2018 Apr;110(2):190-196. doi: 10.1016/j.jnma.2017.05.002. Epub 2017 Jun 7. PMID: 29580454

24.  Perry RG, Mitchell JA, Hawkins J, Johnson-Lawrence V. The Role of Age and Multimorbidity in Shaping Older African American Men's Experiences with Patient?Provider Communication. Geriatrics (Basel). 2018 Oct 24;3(4):74. doi: 10.3390/geriatrics3040074.PMID: 31011109 

25.  Perry RG, Mitchell JA, Hawkins J, Johnson-Lawrence V. The Role of Age and Multimorbidity in Shaping Older African American Men's Experiences with Patient?Provider Communication. Geriatrics (Basel). 2018 Oct 24;3(4):74. doi: 10.3390/geriatrics3040074. PMID: 31011109

26.  Robinson-Lane SG, Vallerand AH. Pain Treatment Practices of Community-Dwelling Black Older Adults. Pain Manag Nurs. 2018 Feb;19(1):46-53. doi: 10.1016/j.pmn.2017.10.009. Epub 2017 Dec 14. PMID: 29248605

27.  Robinson-Lane SG. Adapting to chronic pain: A focused ethnography of black older adults. Geriatr Nurs. 2019 Aug 31:S0197-4572(19)30188-0. doi: 10.1016/j.gerinurse.2019.08.001. Online ahead of print. PMID: 31481258

28.  Sneed RS, Key K, Bailey S, Johnson-Lawrence V. Social and psychological consequences of the COVID-19 pandemic in African-American communities: Lessons from Michigan. Psychol Trauma. 2020 Jul;12(5):446-448. doi: 10.1037/tra0000881. Epub 2020 Jun 11. PMID: 32525371

29.  Spencer MS, Kieffer EC, Sinco B, Piatt G, Palmisano G, Hawkins J, Lebron A, Espitia N, Tang T, Funnell M, Heisler M. Outcomes at 18 Months From a Community Health Worker and Peer Leader Diabetes Self-Management Program for Latino Adults. Diabetes Care. 2018 Jul;41(7):1414-1422. doi: 10.2337/dc17-0978. Epub 2018 Apr 27. PMID: 29703724 

30.  Tipirneni R, Ganguli I, Ayanian JZ, Langa KM. Reducing Disparities in Healthy Aging Through an Enhanced Medicare Annual Wellness Visit. Public Policy Aging Rep. 2019 Jan;29(1):26-32. PMCID: PMC6529776 [Available on 2019-12-18]




Minority Trainee(s):
  • Carlos Aguilar, Ph.D, Assistant Professor, University of Michigan Biomedical Engineering
    PESC 2019: Probing the relationship of the neuromuscular junction muscle stem cells in aging
  • Daniela Ponce-Balbuena, Ph.D, Research Investigator, University of Michigan Cardiovascular Medicine
    PESC 2019: Exploring the impact of neuronal vulnerability to aging-related disorders on spatial learning in C. elegans model organism
  • Jaclynn Hawkins, Ph.D. , Assistant Professor, University of Michigan School of Social Work, Associate Director of the Gender and Health Research Lab’
    REC & PESC Recipient 2020 Type 2 Diabetes Self-Management in Older African American Men: A Peer Leader Pilot Intervention
  • Sheria Robinson-Lane, Ph.D, Assistant Professor, University of Michigan School of Nursing
    PESC 2019: Towards a Culturally Responsive Intervention for Black Caregivers of Persons with Dementia

Minority Grant(s):