Claude D. Pepper Older Americans Independence Center

Principal Investigator    Raymond Yung, M.D.  734-647-9746
Program Administrator    Stephanie Gatica, B.A.  734-763-1118

Funded by the NIA as the nations first Geriatric Research and Training Center in 1989, the University of Michigan (UM) Pepper Center has evolved to meet the objectives of the OAIC program with successful competing renewals as an OAIC in 1994, 1999, 2004, 2009, 2015, and 2020. Thus, our Center is completing its 31st consecutive year of operation in 2020. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults.   Drawing on the large base of research currently underway in the fields of geriatrics and gerontology at UM, the UM Pepper Center fosters collaborative multidisciplinary research to integrate basic science, clinical science, and health services research relevant to the health care problems of older adults. The UM Pepper Center grant supports important research activities of the UM Geriatrics Center. Founded in 1987, the Geriatrics Center is the umbrella organization for geriatrics research, education, and patient care at the University of Michigan.

The specific goals of the UM Pepper Center are:

1.    To support research that will improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status.

2.    To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status.

3.    To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus.

4.    Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus.

5.    Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center’s research focus.

Faculty from the following UM Schools and Institutes are involved: the Institute of Gerontology, School of Public Health, Institute for Social Research, Medical School, College of Engineering, School of Nursing, School of Social Work, and College of Literature, Science, and the Arts. As of 2018 there were 89 active NIA grants at the UM with over $60 million/year of total costs. The UM OAIC’s faculty participant data base includes a total of 239 current UM faculty who have 221 current external grants relevant to the UM Pepper Center’s focus totaling over $57 million/year direct costs.

Leadership and Administrative Core (LAC)
Leader 1:    Raymond Yung, MD
Leader 2:    Lona Mody, MD, MSc

A well-defined and effective Leadership Administrative Core (LAC) that supports the rich activities of the OAIC is already in place. The faculty and staff in the LAC have proven leadership and administrative skills. The LAC will foster critical interactions among the OAIC Program Director, the OAIC Core Directors/Co-Directors and the leadership structure of the Institution as a whole. These linkages are fostered by the proven administrative structure, which requires meetings of the OAIC leadership on a regular and ongoing basis, and of key advisory committees: the UM Geriatrics Center’s Research Operating Committee (ROC) and the OAIC External Advisory Board (EAB). The ROC, led by two fellowship-trained geriatricians/physician scientists (Yung, Mody) with complementary expertise and research interests, provides strategic planning, coordination and oversight for all OAIC activities. The membership of the ROC includes the LAC Leader and Co-Leader, the former OAIC Director, the ten other OAIC Core Directors/Co-Directors, and Geriatrics Center administrative leaders.

Research Education Component (REC)
Leader 1:    Neil B. Alexander, MD
Leader 2:    Lillian Min, MD, MSHS
Leader 3:    Carrie Karvonen-Gutierrez
The REC is a component of the Claude D. Pepper Older Americans Independence Center, funded by the National Institute on Aging. The primary goal of the Research Education Core is to recruit, select, support, mentor, and train junior faculty to become independent investigators in aging-related research and academic leaders in geriatrics and gerontology within their respective disciplines. The REC focuses on stimulating the translation between basic and clinical research across the spectrum of its training activities, including the annual research education core retreat(link is external). To this end it serves a critical function in supporting the overall OAIC focus by training the next generation of investigators whose research will lead to an improved understanding of the predictors and modulators of the aging phenotype.

Pilot and Exploratory Studies Core (PESC)
Leader 1:    Lona Mody, MD
Leader 2:    Donovan Maust, MD

The goal of the Pilot and Exploratory Studies Core is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme:

“To improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status”

The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research.

Leader 1:    James Ashton-Miller, PhD
Leader 2:    Neil Alexander, MD

The Biomechanics Core provides an array of techniques and equipment for the precise experimental quantification of physical functioning of healthy and frail elders in order to investigate attributes of the aging phenotype. It also supplies support for theoretical investigations in the form of computer simulation models to analyze the elements of those functional abilities and to establish the major determinants of abilities to perform motor acts in an effective manner. The Core is physically based in the Biomechanics Research Laboratory(link is external) (directed by Dr. Ashton-Miller) and the Mobility Research Center(link is external) (directed by Dr. Alexander).

Physical disabilities are epidemic in the elderly. Whatever the underlying pathologies, these disabilities express themselves in biomechanical terms: reduced muscular strengths and rates of developing strengths, limited ranges and speeds of motion, reduced afferent feedback, inappropriate body segment coordination patterns, difficulty with balance and fall arrests, and even impaired pelvic floor and continence system function.

The Biomechanics Core will contribute to the development of academic leaders in geriatrics by helping interested faculty and their fellows to analyze a range of geriatric problems through biomechanical research techniques. Thus, it will train them through directed study involving background reviews, hypothesis generation, interdisciplinary pilot research projects, and data analysis and interpretation to examine issues adversely affecting the physical abilities of the elderly.

Core Facility for Aged Rodents (CFAR)
Leader 1:    Richard Miller, MD, PhD

The Core Facility for Aged Rodents, CFAR, has been a major feature of the University of Michigan Claude Pepper Center since its inception in 1989. CFAR serves the needs of Pepper Center investigators through four Specific Aims.

  1. CFAR will provide advice to all OAIC investigators, from student through faculty levels, in the use of rodents for research into the biology of aging and its role in late life disease.
  2. CFAR will support specialized colonies of mice particularly well suited for research on the biology of aging and its relationship to late-life disease. These include (a) genetically heterogeneous mice of the UM-HET3 stock; (b) calorically restricted UM-HET3 mice; and (c) mice of the long-lived Snell dwarf (dw/dw) stock, carrying the Pit1 dw mutation. Mice from these colonies will be provided to faculty members working on Pilot Studies Exploratory Core (PESC) and Research Career Development Core (RCDC) research projects, as well as to Geriatrics Center faculty members who wish to conduct pilot studies on mouse aging supported by other sources of NIA funds.
  3. CFAR funds will support the development of new animal models for specific purposes. In the first year, these will include a new four-way cross suitable for studies of late-life hearing loss.

Design, Data, and Biostatistics Core (DDBC)
Leader 1:    Andrzej Galecki, PhD, MD
Leader 2:    Julie Bynum, M.D., M.Ph.
The Design, Data, and Biostatistics Core (DDBC) will provide technical support and training of investigators developing or performing intervention and other geriatric research projects examining the aging phenotype and outcomes research. It will also develop new instruments, methodologies, and data archives to enable future studies. Thus the DDBC will both address techniques for appropriate design and execution of current experiments and set the foundation for future research studies. Building on our experience with the UM Pepper Center, the DDBC will address the needs of OAIC investigators, and especially junior investigators, for assistance in the design of intervention experiments, and the collection, maintenance, analysis, and interpretation of their data.

Human Subjects and Assessment (HSAC)
Leader 1:    Raymond Yung, MD
Leader 2:    Kenneth Langa, MD, PhD

The Human Subjects and Assessment Core (HSAC) supports activities involving human subjects at the University of Michigan Claude D. Pepper Center.  It has four specific aims:

  • HSAC will establish, maintain, and facilitate access to human subjects and related data sets.
  • HSAC will expand, promote and facilitate access to minority human subjects through collaborative linkages with the Wayne State University Institute of Gerontology (WSU IoG).
  • HSAC aims to provide selected efficient physical health measures, which will complement our existing collection of self-reported health, health care utilization, and psychosocial measures in subject selection.
  • HSAC will provide training and consultation to investigators on issues related to (a) recruitment and retention of human subjects, and (b) measurement of quality of life and psychosocial factors closely linked with aging phenotype.

REC Scholar, Research & Grants Funded During Pepper Supported Time Years Publications
Jiha Lee, MD, MHS
Assistant Professor / University of Michigan
Assistant Professor
2019-2021  0 (0 1st/Sr)
Xiaoling Xiang
Assistant Professor / University of Michigan School of Social Work
Acceptability of home care worker-supported, technology-based treatment for late-life depression in non-skilled home care
  • Blue Cross Blue Shield of Michigan Foundation (#02748.II) Happy@Home: Training personal care aides to administer online therapy for depression in homecare seniors Role: Principal Investigator Direct cost: $65,000 Dates: 04/01/2019-09/30/2020
  • Michigan-HHS/DHHS-Medicare/Medicaid (E20202768-00) MIP: Implementation of technology-assisted psychotherapy in non-skilled home care. Role: Principal Investigator Direct cost: $36,872 Dates: 10/01/2019-09/30/2020
  • Michigan-HHS/DHHS-Medicare/Medicaid (E20193400-00) MIP: Implementation of technology-assisted psychotherapy in non-skilled home care. Role: Principal Investigator Direct cost: $28,128 Dates: 04/01/2019-09/30/2019
  • University of Michigan Mcubed Diamond Cube (#9501) Improving Quality of Care for Memory Loss Patients Role: Co-Investigator (PI: D. Maust) Direct cost: $60,000 Dates: 06/01/2019-05/31/2020

2019-2021  57 (31 1st/Sr)
Emily Briceno, Ph.D.
Clinical Assistant Professor / Department of Physical Medicine & Rehabilitation, University of Michigan Medical School
Measurement of cognition across language and education among Mexican American and non-Hispanic white older adults
2020-2021  4 (2 1st/Sr)
Michael Smith, PharmD
Clinical Associate Professor of Pharmacy / University of Michigan College of Pharmacy
Understanding medication use in older adult cancer survivors with centralized pain, focusing on practice patterns
2021-2022  9 (5 1st/Sr)
Matthew Pianko, M.D.
Clinical Assistant Professor of Internal Medicine / Department of Internal Medicine, Michigan Medicine
Evaluating the impact of immunosenescence and inflammaging on vaccine-induced immunity in older adults with plasma cell neoplasms
2021-2022  4 (3 1st/Sr)

Past Scholars
Marco Cassone, MD, PhD, University of Michigan, Geriatrics & Palliative Medicine (2018-2020)
Jaclynn Hawkins, University of Michigan School of Social Work (2019-2020)

1. Project Title: Type 2 Diabetes Self-Management in Older African American Men: A Peer Leader Pilot Intervention
  Leader: Jaclyn Hawkins

PESC Year 16 (7/1/20-6/30/21)

The overall objectives of the proposed study are to: (1) systematically adapt and preliminarily validate a peer leader type 2 diabetes (T2D) self-management support intervention designed to improve diabetes-related lifestyle and self-management behaviors in older Black men with T2D and (2) to evaluate the relevance and acceptability of the adapted intervention in preparation for subsequent trials.

2. Project Title: De-escalation of bDMARDS in Rheumatoid Arthritis in Older Adults with RA
  Leader: Jiha Lee

PESC Year 16 (7/1/20-6/30/21)

The overarching goal of this project is to test the feasibility of identifying de-escalation of bDMARDs using Medicare claims data necessary for me to study drivers of variation in de-escalation of bDMARDs among older adults with RA.  

3. Project Title: Home-delivered Meals to Prevent Recurrent Hepatic Encephalopathy in Older Adults
  Leader: Elliot Tapper

PESC Year 16 (7/1/20-6/30/21)

The goal is to determine if home delivered meal programs reduce the recurrent risk of hepatic encephalophaty

4. Project Title: Pathway to De-escalation: Characterizing antibiotic prescribing cascades in older adults
  Leader: Valerie Vaughn

PESC Year 16 (7/1/20-6/30/21)

The goal is to describe the full phenotype of non-specific signs and symptoms in older adults entering into the antibiotic prescribing cascade and identify risk factors associated with such symptoms.

5. Project Title: Probing the relationship of the neuromuscular junction on muscle stem cells in aging
  Leader: Carlos Aguilar

PESC Year 15 (7/1/19-6/30/20)

6. Project Title: Exploring the impact of neuronal vulnerability to aging-related disorders on spatial learning in C. elegans model organism
  Leader: Daniela Ponce-Balbuena

PESC Year 15 (7/1/19-6/30/20)

7. Project Title: Ectonucleotidase modulation of age determined vascular calcification and fibrosis
  Leader: Nadia Sutton

PESC Year 15 (7/1/19-6/30/20)

8. Project Title: Diet-induced cellular senescence and thermogenic fat function
  Leader: Jun Wu

PESC Year 15 (7/1/19-6/30/20)

9. Project Title: Exploring the impact of neuronal vulnerability to aging-related disorders on spatial learning in C. elegans model organism
  Leader: Eleni Gourgou

PESC Year 15 (7/1/19-6/30/20)

10. Project Title: Recommendations and Alerting for Delirium Alleviation in Real-Time (RADAR): Pilot Trial
  Leader: Phillip Vlisides

PESC Year 15 (7/1/19-6/30/20)

11. Project Title: Towards a Culturally Responsive Intervention for Black Caregivers of Persons with Dementia
  Leader: Sheria Robinson-Lane

PESC Year 15 (7/1/19-6/30/20)

12. Project Title: How metabolic profiles change with aging and are affected by protein aggregation
  Leader: Matthias Truttman

PESC Year 15 (7/1/19-6/30/20)

13. Project Title: Viral Infection Burden and Immunosenescence
  Leader: Grace Noppert, Ph.D.

PESC Year 17 (7/1/21-6/30/22)

Adults aged 65+ years account for 45% of hospitalizations and 53% of intensive care admissions due to COVID-19 despite comprising 17% of the U.S. population. The systemic hyperinflammatory response is a key feature observed in many severe cases of COVID-19 and may signal an underlying immunopathology related to substantial T cell stimulation. This immunopathology is likely an indication of advanced immunological age, or immunosenescence. irhe mechanisms underlying the increased risk for severe outcomes, including mortality, from COVID-19 among older adults are still being elucidated. Emerging evidence suggests that viral infections may accelerate the pace of immunosenescence. However, significant questions remain With regards to the role of viral co-infections, differential immune control of viral infections, and the ??pecific changes in the immune compartment induced by viral infections.

Our long-term goal is to examine the role of viral infections in driving population-level patterns of immunosenescence. The overall obiective of the current application is to characterize the viral burden resulting from five herpesviruses by examining both seropositivity to each virus as well as antibody level with higher antibody levels reflecting worse immune control of the virus and thus a greater burden to the immune system.

Using previously collected human samples from the University of Michigan's Central Biorepository, we will first characterize the viral infection burden to five human herpesesviruses and describe differences by age, race/ethnicity, and gender (Aim 1 ). We will then estimate whether viral infection burden is associated with advanced immunosenescence in the T cell compartment (Aim 2). At its conclusion, these pilot data will shed further light on the immune parameters most likely to be affected by viral infections. Ultimately, the goal of this work to provide insights into future development of interventions that can address long-term immune consequences older adults are likely to continue to face due to viral infections.

14. Project Title: Aging and tryptophan immune metabolism in CKD associated cardiovascular disease
  Leader: Anna Mathew, M.B.B.S.

PESC Year 17 (7/1/21-6/30/22)

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD), reducing CKD patients' life expectancy. However, the accelerated CVD pathogenesis in CKD is not yet clearly understood, and no specific therapeutic strategies are currently available to attenuate this phenomenon. Our Jong-term goal is to understand the role of aging and immune-metabolic mechanisms underlying accelerated atherosclerosis to improve CKD patients' lifespan. Our overall objective is to define the role of aging and tryptophan catabolism via the kynurenine pathway (KP) in the pathophysiology of CKD atherosclerosis. Our central hypothesis is that the macrophage-derived tryptophan catabolite kynurenic acid (KA) causes CKD atherosclerosis in older CKD patients, whereas 3-hydroxy anthranilic acid (3-HAA) ameliorates this problem. Our rationale is that if KP metabolites play a causal role in CKD atherosclerosis in older adults, then we can develop new therapeutic strategies and biomarkers to attenuate the CVD burden in the CKD population.

We will test our central hypothesis by pursuing the following specific aims: 1) demonstrating the role of aging and macrophage-derived KP metabolites in the pathophysiology of CKD related CVD, and 2) delineating the mechanisms downstream of KP metabolites (namely KA and 3-HM) in the pathogenesis of CKD atherosclerosis. Under Aim 1, we will delineate the role of aging and peripheral blood mononuclear cell KP metabolism on CVD in CKD patients. Regarding Aim 2, we plan to demonstrate that KA causes CKD atherosclerosis by acting on macrophage cytosolic aryl hydrocarbon and cell-membrane G protein-coupled receptor 35 receptors, whereas 3-HM ameliorates CKD atherosclerosis by acting on the macrophage inflammasome using primary macrophage cultures. 

15. Project Title: Aging Associated Transcriptional Changes of Metabolic Pathways in the Kidney
  Leader: Jennifer Schaub, M.D.

PESC Year 16 (7/1/20-6/30/21)

Chronic Kidney Disease (CKD) is a global health epidemic, particularly among the elderly. Pathologic analysis of the aging kidney shows nephrosclerosis, which includes global glomerulosclerosis, interstitial fibrosis, tubular atrophy and atherosclerosis. Vascular changes are an integral part of nephrosclerosis and may be linked to tubular injury and atrophy, but this is understudied because it is difficult to assess the vasculature, which is often not sampled in kidney biopsy specimens. While interstitial fibrosis and tubular atrophy are the strongest known pathologic predictors of progression of CKD, we have limited understanding of how vascular disease and aging contributes to tubular cell atrophy and transcriptional changes in glycolysis and oxidative metabolism pathways. It is critical to better understand how transcriptional regulation of these metabolic pathways in tubular cells are altered with aging and vascular disease, as Prolyl Hydroxylase Inhibitors (PHI), novel therapeutic agents that increase the activity of Hypoxia Inducible Factors, are effective treatments for anemia of CKD. Mechanistic data shows that PHI may alter transcriptional regulation of metabolic pathways within the kidney and could alter the progression of kidney disease. The PRECISE cohort, a cohort of nephrectomy specimens, has abundant sampling of vasculature and is a unique opportunity to evaluate the relationship between aging, vascular disease, tubular atrophy and transcriptional regulation of metabolism.

The proposed studies will assess a) the relationship between tubular atrophy, vascular disease and aging from a morphometric perspective and b) the changes in the tubular cell specific expression of genes involved in glycolysis and oxidative metabolism in those with vascular disease and aging kidneys. We will then generate the transcriptional data from kidneys that have already been harvested from the Glenn Mouse Aging Study and align these results with the human data. In addition, we will use publically available gene expression data from animal models treated with PHI to assess how these agents impact transcriptional expression of metabolic pathways. Results from these studies can be used for potential future collaborations with the Core Facility for Slow Aging Mice. 

16. Project Title: Supporting older adults with cognitive impairment before elective surgery; Developing a measure of preoperative preparedness of patient-caregiver dyads
  Leader: Alexandra Norcott, M.D., M.Sc.

PESC Year 17 (7/1/21-6/30/22)

The proposed study has two specific aims:

1. Identify the core domains of transitional preparedness to address in the preoperative period: We will conduct pre and postoperative qualitative interviews of patients with cognitive impairment and their designated caregivers to identify core domains of transitional preparedness. We will also measure caregivers' perceived locus of control and caregiving contributions.

2.Develop a preoperative measure of dyad transitional preparedness: Using the HSAC volunteer pool, we will develop a measure of dyad transitional preparedness in older adults with cognitive impairment. We will then evaluate our measure's validity and reliability in 20 dyads before elective surgery.

Significance: Data from this study will serve as pilot data for a successful application for a career development award where this tool can be validated in a larger population of caregivers; and, the association between d ad re aredness and ost-o erative outcomes can be tested. 

17. Project Title: The Neural Mechanisms Linking Hearing Loss and Cognitive Decline in Aging
  Leader: Gideon Rothschild, Ph.D.

PESC Year 17 (7/1/21-6/30/22)

Mounting epidemiological studies in recent years suggest that hearing loss is associated with cognitive decline in both normal aging and dementia. However, whether these findings reflect a causal link, and if so- by what neural mechanisms, remains unknown. Determining whether hearing loss causally promotes cognitive decline and identifying the underlying neural mechanisms would have far-reaching clinical implications to benefit the aging population.

To address this goal, here we propose to combine cutting edge electrophysiological recording techniques with neural inactivation in mice models of aging. We will focus on a critical yet understudied communication pathway between the auditory cortex (AC) and the lateral entorhinal cortex (LEC).

This channel of communication links the auditory system with the hippocampal memory circuit, and is thus a major candidate pathway underlying the link between hearing loss and cognitive decline. While it is well-established that noise-induced hearing loss (NIHL) induces aberrant hyperactivity in the AC, the consequence on the LEC remains unknown. We will record neural activity across the AC and LEC in awake mice and examine how NIHL influences communication and neural information processing across these regions. We will then use chemogenetic neural inactivation to determine the causal influence of AC hyperactivity on the downstream LEC target. Finally, we will test the consequence of AC hyperactivity on behavioral memory performance. Together, our experiments will provide critical causal and mechanistic insight regarding the link between hearing loss and cognitive decline

18. Project Title: Age-specific biomechanical model of pelvic floor support
  Leader: Luyun Chen, M.S., M.A., Ph.D.

PESC Year 17 (7/1/21-6/30/22)

The goal of this pilot study is to quantify the age-related ICM and cardinal ligament (CL) length change per decade in living women (Aim 1) and create an age-specific pelvic floor biomechanical model to investigate the aging's contribution to the POP development (Aim 2).

Aim 1: Secondary MRI analysis for aging-related ICM shape change and its correlation with levator 'bowl‘ volume (LBV) and cardinal ligament (CL) length.: Develop MRI-based shape analysis strategy to quantify the age-related change on ICM among "young" (<40 y), "mid-age" (50-60 y) and "old" (;:=:70 y) nulliparous women. We expect that concaved ICM in "older" women contribute to the increase of levator "bowl" volume resulting longer CL length.

Aim 2: Age-specific pelvic floor biomechanical model: Create age-specific biomechanical model to investigate the contribution of age-specific change to the POP development using shape analysis to parameterize age-related ICM shape changes together with CL length change. An array of FEM models Mtith various degree age-related ICM changes loaded with increasing intra-abdominal pressure. The apical tension will be calculated as outcome variable. We expect age-related changes would greatly increasing the apical tension and increase the risk of POP development.

19. Project Title: The impact of frailty and immunosenescence on SARS-CoV-2 vaccination outcomes in older adults with plasma cell disorders
  Leader: Matthew Pianko, M.D.

PESC Year 16 (7/1/20-6/30/21)

The global pandemic infectious disease COVID-19 caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused worldwide devastation, and a strikingly high mortality rate of 30-55% in multiple myeloma (MM) patients aged 65 years or more. While the advent of effective and safe vaccines against SARS-CoV-2 provides hope, both MM patients and elderly adults are known to have suboptimal antibody responses to vaccines and the effectiveness of these novel vaccines in this population is unknown because immunocompromised persons were excluded from the phase Ill trials of SARS-CoV-2 vaccines. The long-term goal of this project is to gain deeper insight into the impacts of frailty and age-related immune dysfunction on immune response to vaccination in aged adults with plasma cell disorders in order to optimize vaccination strategies for these patients. The central hypothesis is that frailty can predict suboptimal immune responses to SARS-CoV-2 vaccinations in patients with plasma cell neoplasms. The rationale for this project is that frailty is predictive of clinical outcomes in MM and the aged immune system affects vaccine responses in frail and non-frail persons.

The central hypothesis will be tested by pursuing two Specific Aims: 1) To estimate the impact of frailty on immunogenicity of SARS-CoV-2 vaccines in older adults with plasma cell neoplasms in a prospective pilot-phase observational cohort study; and 2) Determine the impact of B cell immunosenescence on SARS-CoV-2 vaccination outcomes in older adults with plasma cell neoplasms.

Under the first Aim, a validated geriatric assessment will be performed, SARS-CoV-2 Spike antibodies will be quantified at 4-6 weeks after vaccination, and rates of suboptimal immune responses will be compared in frail and non-frail individuals stratified by clinical factors. Under the second Aim, functional assessment of antibody-binding affinity will be evaluated using a pseudo-typed virus neutralization assay. The research proposed in this application is innovative because it seeks to evaluate the impact of frailty on the immunogenicity of a novel vaccine type in a population at great need of protection from morbidity and mortality from severe COVID19. The proposed research is significant because it is expected to provide justification and preliminary data to prospectively evaluate methods to improve vaccination outcomes for individuals at high risk of lethal infectious diseases. This work will provide key support for career development and will fund generation of preliminary data to obtain external fundino support.
DEVELOPMENT PROJECTS (2 Development Projects Listed)
1. Project Title: Design, Data and Biostatistics Core Development Project
  Leader: Andrzej Galecki; Julie Bynum

Software tools for separable covariance models in multivariate longitudinal data/repeated measures analysis.

2. Project Title: Biomechanics Core Development Project
  Leader: James Ashton-Miller

Develop a real time sensor to detect hyponatremia

RESEARCH (8 Projects Listed)
    NIH K01AG054615 / (2017-2022)
  ABSTRACT Osteoarthritis (OA), a debilitating age-related disease associated with pain, stiffness and poor functioning is a major risk factor for mobility disability. Although early osteoarthritic changes within the joint commence during mid-life (40-65 years of age), early detection of disease is limited given the lack of robust and reliable OA biomarkers. Currently detection relies upon costly im...
    NIH K01AG054615 / (2017-2022)
  ABSTRACTOsteoarthritis (OA), a debilitating age-related disease associated with pain, stiffness and poor functioning is amajor risk factor for mobility disability. Although early osteoarthritic changes within the joint commence duringmid-life (40-65 years of age), early detection of disease is limited given the lack of robust and reliable OAbiomarkers. Currently detection relies upon costly imagin...
    NIH K01AG062754 / (2020-2024)
  This K01 application proposes career development and research activities customized to facilitate the candidates (Dr. Noah Webster) transition from conducting basic social science research to behavioral intervention research. The candidates long-term career goals include becoming an independent research scientist conducting research aimed at: a) improving the health and independence of older adult...
  Leader(s): WEI, MELISSA
    NIH K23AG056638 / (2017-2022)
  Project Summary / AbstractMultimorbidity, the coexistence of multiple chronic conditions, poses a major and growing challenge to agingadults, their families, and healthcare systems. Most older adults have multiple chronic conditions that interactto profoundly affect physical functioning and health-related quality of life. Despite this, critical gaps remain inthe measurement of multimorbidity. In p...
  Leader(s): LEE, JUN HEE
    NIH R01DK114131 / (2018-2021)
  PROJECT SUMMARY/ABSTRACTNon-alcoholic fatty liver disease (NAFLD), typically associated with overnutrition and obesity, is one of themost common liver diseases, both in the U.S. and worldwide, with a prevalence of 20-30%. During obesity andNAFLD, lipotoxic injuries to hepatocytes can induce the formation of protein inclusions consisting ofp62/SQSTM1 and ubiquitinated proteins. These inclusions can...
    AHRQ R01HS027431 / (2020-2024)
  Considered one of the most urgent microbial threats by the Centers for Disease Control and Prevention (CDC), estimates of the excess costs of C. difficile infection (CDI) to the healthcare system range from $897 million to over $4 billion. Our long-term goal is to develop tools to identify patients at risk for CDI that could reduce its incidence, decrease transmission, improve patient outcomes, an...
  Leader(s): CHOPRA, VINEET
    AHRQ R18HS025891 / (2018-2022)
  Use of peripherally inserted central catheters (PICCs) for intravenous antibiotics, infusion ofchemotherapy or invasive hemodynamic monitoring has grown substantially in hospitalizedpatients. Although such use reflects advantages of PICCs (such as safer insertion in veins ofthe arm compared to veins of the neck or chest for conventional central venous catheters), notall PICCs are placed for approp...
  Leader(s): FURR-HOLDEN, C. DEBRA M
    NIH U54MD011227 / (2016-2021)
  The proposed Flint Center for Health Equity Solutions will establish an NIMHD Transdisciplinary CollaborativeCenter (TCC) for health disparities research on chronic disease prevention to be based in Flint, Michigan. Thisproposal was developed in collaboration with community members from its inception, and evolved from aconversation between Flint community members and the Flint-based Michigan State...
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    Am J Kidney Dis, 2021 May, 77(5): 673-683.e1 | PMID: 33301877 | PMCID: PMC8102017
    Citations: | AltScore: 170.93
  7. Medicare beneficiary panel characteristics associated with high Part D biologic disease-modifying anti-rheumatic drug prescribing for older adults among rheumatologists.
    Lee J, Chang CH, Yung R, Bynum JPW
    Medicine (Baltimore), 2021 Apr 23, 100(16): e25644 | PMID: 33879745 | PMCID: PMC8078346
    Citations: | AltScore: NA
  8. Preexisting Mild Cognitive Impairment, Dementia, and Receipt of Treatments for Acute Ischemic Stroke.
    Levine DA, Galecki AT, Morgenstern LB, Zahuranec DB, Langa KM, Kabeto MU, Okullo D, Nallamothu BK, Giordani B, Reale BK, Campbell M, Lisabeth LD
    Stroke, 2021 Jun, 52(6): 2134-2142 | PMID: 33902296 | PMCID: PMC8154649
    Citations: | AltScore: 3.95
  9. Sex Differences in Cognitive Decline Among US Adults.
    Levine DA, Gross AL, Brice?o EM, Tilton N, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Hingtgen S, Elkind MSV, Manly JJ, Gottesman RF, Gaskin DJ, Sidney S, Sacco RL, Tom SE, Wright CB, Yaffe K, Galecki AT
    JAMA Netw Open, 2021 Feb 1, 4(2): e210169 | PMID: 33630089 | PMCID: PMC7907956
    Citations: 1 | AltScore: 131.43
  10. Effect of Aspirin on Cancer Incidence and Mortality in Older Adults.
    McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, Ford L, Haydon A, Kirpach B, Macrae F, McLean C, Millar J, Murray AM, Nelson MR, Polekhina G, Reid CM, Richmond E, Rodr?guez LM, Shah RC, Tie J, Umar A, Londen GJV, Ronaldson K, Wolfe R, Woods RL, Zalcberg J, Chan AT, ASPREE Investigator Group.
    J Natl Cancer Inst, 2021 Mar 1, 113(3): 258-265 | PMID: 32778876 | PMCID: PMC7936068
    Citations: 10 | AltScore: 388.96
  11. A Method to Quantify Mean Hypertension Treatment Daily Dose Intensity Using Health Care System Data.
    Min L, Ha JK, Aubert CE, Hofer TP, Sussman JB, Langa KM, Tinetti M, Kim HM, Maciejewski ML, Gillon L, Larkin A, Chan CL, Kerr EA, Bravata D, Cushman WC
    JAMA Netw Open, 2021 Jan 4, 4(1): e2034059 | PMID: 33449097 | PMCID: PMC7811181
    Citations: | AltScore: 56
  12. Financial Presentation of Alzheimer Disease and Related Dementias.
    Nicholas LH, Langa KM, Bynum JPW, Hsu JW
    JAMA Intern Med, 2021 Feb 1, 181(2): 220-227 | PMID: 33252621 | PMCID: PMC7851732
    Citations: 1 | AltScore: 1054.4
  13. Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19.
    Pitt B, Sutton NR, Wang Z, Goonewardena SN, Holinstat M
    Eur J Pharmacol, 2021 May 5, 898: 173988 | PMID: 33667455 | PMCID: PMC7923868
    Citations: 1 | AltScore: 13.55
  14. Unwelcome Companions: Loneliness Associates with the Cluster of Pain, Fatigue, and Depression in Older Adults.
    Powell VD, Abedini NC, Galecki AT, Kabeto M, Kumar N, Silveira MJ
    Gerontol Geriatr Med, 2021 Jan-Dec, 7: 2333721421997620 | PMID: 33709010 | PMCID: PMC7907946
    Citations: | AltScore: 9.3
  15. Coping and adaptation to dementia family caregiving: A pilot study.
    Robinson-Lane SG, Zhang X, Patel A
    Geriatr Nurs, 2021 Jan-Feb, 42(1): 256-261 | PMID: 32891443 | PMCID: PMC7921211
    Citations: | AltScore: NA
  16. Cap-independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17a-estradiol.
    Shen Z, Hinson A, Miller RA, Garcia GG
    Aging Cell, 2021 May, 20(5): e13345 | PMID: 33742521 | PMCID: PMC8135077
    Citations: | AltScore: 12.2
  17. Planning for Driving Retirement: The Effect of Driving Perceptions, Driving Events, and Assessment of Driving Alternatives.
    Vivoda JM, Cao J, Koumoutzis A, Harmon AC, Babulal GM
    Transp Res Part F Traffic Psychol Behav, 2021 Jan, 76: 193-201 | PMID: 33716551 | PMCID: PMC7945980
    Citations: | AltScore: NA
  18. Development, Validation, and Performance of a New Physical Functioning-Weighted Multimorbidity Index for Use in Administrative Data.
    Wei MY, Luster JE, Ratz D, Mukamal KJ, Langa KM
    J Gen Intern Med, 2021 Jan 19 | PMID: 33469748
    Citations: | AltScore: 0.75
  19. Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggests aspirin did not improve outcomes in older adults with chronic kidney disease.
    Wolfe R, Wetmore JB, Woods RL, McNeil JJ, Gallagher H, Roderick P, Walker R, Nelson MR, Reid CM, Shah RC, Ernst ME, Lockery JE, Tonkin AM, Abhayaratna WP, Gibbs P, Wood EM, Mahady SE, Williamson JD, Donnan GA, Cloud GC, Murray AM, Polkinghorne KR
    Kidney Int, 2021 Feb, 99(2): 466-474 | PMID: 32920022 | PMCID: PMC7957958
    Citations: | AltScore: 82
  20. Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents.
    Wu KH, Hornsby WE, Klunder B, Krause A, Driscoll A, Kulka J, Bickett-Hickok R, Fellows A, Graham S, Kaleba EO, Hayek SS, Shi X, Sutton NR, Douville N, Mukherjee B, Jamerson K, Brummett CM, Willer CJ
    PLoS One, 2021, 16(2): e0246447 | PMID: 33556117 | PMCID: PMC7870003
    Citations: | AltScore: NA
  21. Dual Trajectories of Social Isolation and Dementia in Older Adults: A Population-Based Longitudinal Study.
    Xiang X, Lai PHL, Bao L, Sun Y, Chen J, Dunkle RE, Maust D
    J Aging Health, 2021 Jan, 33(1-2): 63-74 | PMID: 32865104 | PMCID: PMC7855508
    Citations: | AltScore: 7
  22. Childhood adversity and major depression in later life: A competing-risks regression analysis.
    Xiang X, Wang X
    Int J Geriatr Psychiatry, 2021 Jan, 36(1): 215-223 | PMID: 32869351
    Citations: | AltScore: NA
  23. The Impact of Late-Life Disability Spectrum on Depressive Symptoms: A Fixed-Effects Analysis of Panel Data.
    Xiang X, Yang Y, Cheng J, An R
    J Gerontol B Psychol Sci Soc Sci, 2021 Mar 14, 76(4): 810-819 | PMID: 32357224 | PMCID: PMC7955956
    Citations: | AltScore: 1
  24. Engineered Tools to Study Intercellular Communication.
    Yang BA, Westerhof TM, Sabin K, Merajver SD, Aguilar CA
    Adv Sci (Weinh), 2021 Feb, 8(3): 2002825 | PMID: 33552865 | PMCID: PMC7856891
    Citations: | AltScore: NA
  25. Cardiac response to adrenergic stress differs by sex and across the lifespan.
    Yusifov A, Chhatre VE, Zumo JM, Cook RF, McNair BD, Schmitt EE, Woulfe KC, Bruns DR
    Geroscience, 2021 Mar 2 | PMID: 33651247
    Citations: | AltScore: 0.25
  1. The Relationship of Loneliness to End-of-Life Experience in Older Americans: A Cohort Study.
    Abedini NC, Choi H, Wei MY, Langa KM, Chopra V
    J Am Geriatr Soc, 2020 Mar 3, 68(5): 1064-1071 | PMID: 32128789 | PMCID: PMC7234919
    Citations: 1 | AltScore: 46.95
  2. Vision impairment and depression among older adults in low- and middle-income countries.
    Abou-Hanna JJ, Leggett AN, Andrews CA, Ehrlich JR
    Int J Geriatr Psychiatry, 2020 Aug 4, 36(1): 64-75 | PMID: 32749746 | PMCID: PMC8009049
    Citations: | AltScore: 1.5
  3. Caregiving, Recovery, and Death After Incident ADL/IADL Disability Among Older Adults in the United States.
    Ankuda CK, Levine DA, Langa KM, Ornstein KA, Kelley AS
    J Appl Gerontol, 2020 Apr, 39(4): 393-397 | PMID: 30741065 | PMCID: PMC7105395
    Citations: 2 | AltScore: 2.75
  4. Comparison of anorectal function measured using wearable digital manometry and a high resolution manometry system.
    Attari A, Chey WD, Baker JR, Ashton-Miller JA
    PLoS One, 2020, 15(9): e0228761 | PMID: 32991595 | PMCID: PMC7523952
    Citations: | AltScore: NA
  5. Improvement in trunk kinematics after treadmill-based reactive balance training among older adults is strongly associated with trunk kinematics before training.
    Aviles J, Wright DL, Allin LJ, Alexander NB, Madigan ML
    J Biomech, 2020 Dec 2, 113: 110112 | PMID: 33190053 | PMCID: PMC7736255
    Citations: | AltScore: NA
  6. Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial.
    Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald PB, Mazza C, Agustini B, McNeil JJ
    JAMA Psychiatry, 2020 Oct 1, 77(10): 1012-1020 | PMID: 32492080 | PMCID: PMC7271558
    Citations: 1 | AltScore: 142.63
  7. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.
    Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P, STRIDE Trial Investigators.
    N Engl J Med, 2020 Jul 9, 383(2): 129-140 | PMID: 32640131 | PMCID: PMC7421468
    Citations: 8 | AltScore: 274.196
  8. So Close and Yet So Irritating: Negative Relations and Implications for Well-being by Age and Closeness.
    Birditt KS, Sherman CW, Polenick CA, Becker L, Webster NJ, Ajrouch KJ, Antonucci TC
    J Gerontol B Psychol Sci Soc Sci, 2020 Jan 14, 75(2): 327-337 | PMID: 29596623 | PMCID: PMC7179808
    Citations: 4 | AltScore: 9.08
  9. Methods and Early Recruitment of a Community-Based Study of Cognitive Impairment Among Mexican Americans and Non-Hispanic Whites: The BASIC-Cognitive Study.
    Brice?o EM, Mehdipanah R, Gonzales X, Heeringa S, Levine DA, Langa KM, Garcia N, Longoria R, Morgenstern LB
    J Alzheimers Dis, 2020, 73(1): 185-196 | PMID: 31771059 | PMCID: PMC7282317
    Citations: | AltScore: 11.1
  10. Policies and practices of SHEA Research Network hospitals during the COVID-19 pandemic.
    Calderwood MS, Deloney VM, Anderson DJ, Cheng VC, Gohil S, Kwon JH, Mody L, Monsees E, Vaughn VM, Wiemken TL, Ziegler MJ, Lofgren E
    Infect Control Hosp Epidemiol, 2020 Oct, 41(10): 1127-1135 | PMID: 32571447 | PMCID: PMC7360941
    Citations: 2 | AltScore: 53.55
  11. Interplay Between Patient Colonization and Environmental Contamination With Vancomycin-Resistant Enterococci and Their Association With Patient Health Outcomes in Postacute Care.
    Cassone M, Zhu Z, Mantey J, Gibson KE, Perri MB, Zervos MJ, Snitkin ES, Foxman B, Mody L
    Open Forum Infect Dis, 2020 Jan, 7(1): ofz519 | PMID: 31988973 | PMCID: PMC6976341
    Citations: | AltScore: 3
  12. Age-associated arterial calcification: the current pursuit of aggravating and mitigating factors.
    Chakrabarti A, Goldstein DR, Sutton NR
    Curr Opin Lipidol, 2020 Oct, 31(5): 265-272 | PMID: 32773466 | PMCID: PMC7891872
    Citations: | AltScore: 3.85
  13. Identifying predictors of upper extremity muscle elasticity with healthy aging.
    Chodock E, Hahn J, Setlock CA, Lipps DB
    J Biomech, 2020 Apr 16, 103: 109687 | PMID: 32147243 | PMCID: PMC7168868
    Citations: 1 | AltScore: 4.7
  14. Associations of Frailty Status with Low-Mileage Driving and Driving Cessation in a Cohort of Older Drivers.
    Crowe CL, Kannoth S, Andrews H, Strogatz D, Li G, DiGuiseppi C, Hill L, Eby DW, Molnar LJ, Mielenz TJ
    Geriatrics (Basel), 2020 Mar 19, 5(1):
    pii: E19. | PMID: 32204350 | PMCID: PMC7151033
    Citations: 1 | AltScore: NA
  15. Epidemiology of Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis Colonization in Nursing Facilities.
    Davis E, Hicks L, Ali I, Salzman E, Wang J, Snitkin E, Gibson K, Cassone M, Mody L, Foxman B
    Open Forum Infect Dis, 2020 Jan, 7(1): ofz553 | PMID: 31993459 | PMCID: PMC6979485
    Citations: 3 | AltScore: 0.25
  16. Estrone Is a Strong Predictor of Circulating Estradiol in Women Age 70 Years and Older.
    Davis SR, Martinez-Garcia A, Robinson PJ, Handelsman DJ, Desai R, Wolfe R, Bell RJ, ASPREE Investigator Group.
    J Clin Endocrinol Metab, 2020 Sep 1, 105(9):
    pii: dgaa429. | PMID: 32614391 | PMCID: PMC7394338
    Citations: | AltScore: NA
  17. Uptake of Virtual Visits in A Geriatric Primary Care Clinic During the COVID-19 Pandemic.
    Dewar S, Lee PG, Suh TT, Min L
    J Am Geriatr Soc, 2020 Jul, 68(7): 1392-1394 | PMID: 32383773 | PMCID: PMC7267610
    Citations: 9 | AltScore: 25.75
  18. Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
    Doria A, Galecki AT, Spino C, Pop-Busui R, Cherney DZ, Lingvay I, Parsa A, Rossing P, Sigal RJ, Afkarian M, Aronson R, Caramori ML, Crandall JP, de Boer IH, Elliott TG, Goldfine AB, Haw JS, Hirsch IB, Karger AB, Maahs DM, McGill JB, Molitch ME, Perkins BA, Polsky S, Pragnell M, Robiner WN, Rosas SE, Senior P, Tuttle KR, Umpierrez GE, Wallia A, Weinstock RS, Wu C, Mauer M, PERL Study Group.
    N Engl J Med, 2020 Jun 25, 382(26): 2493-2503 | PMID: 32579810 | PMCID: PMC7375708
    Citations: 7 | AltScore: 319.61
  19. Inhibition of class I PI3K enhances chaperone-mediated autophagy.
    Endicott SJ, Ziemba ZJ, Beckmann LJ, Boynton DN, Miller RA
    J Cell Biol, 2020 Dec 7, 219(12):
    pii: e202001031. | PMID: 33048163 | PMCID: PMC7557678
    Citations: | AltScore: NA
  20. Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly.
    Ernst ME, Chowdhury EK, Beilin LJ, Margolis KL, Nelson MR, Wolfe R, Tonkin AM, Ryan J, Woods RL, McNeil JJ, Reid CM, ASPREE Investigator Group.
    Hypertension, 2020 Dec, 76(6): 1945-1952 | PMID: 33131315 | PMCID: PMC7666049
    Citations: | AltScore: 6.95
  21. Several Roads Lead to Rome: Operationalizing Antibiotic Stewardship Programs in Nursing Homes.
    Furuno JP, Mody L
    J Am Geriatr Soc, 2020 Jan, 68(1): 11-14 | PMID: 31825520
    Citations: | AltScore: 9.3
  22. Trends in Antipsychotic and Mood Stabilizer Prescribing in Long-Term Care in the U.S.: 2011-2014.
    Gerlach LB, Kales HC, Kim HM, Bynum JPW, Chiang C, Strominger J, Maust DT
    J Am Med Dir Assoc, 2020 Nov, 21(11): 1629-1635.e8 | PMID: 32693995 | PMCID: PMC7641905
    Citations: | AltScore: 0.25
  23. Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.
    Gill TM, Bhasin S, Reuben DB, Latham NK, Araujo K, Ganz DA, Boult C, Wu AW, Magaziner J, Alexander N, Wallace RB, Miller ME, Travison TG, Greenspan SL, Gurwitz JH, Rich J, Volpi E, Waring SC, Manini TM, Min LC, Teresi J, Dykes PC, McMahon S, McGloin JM, Skokos EA, Charpentier P, Basaria S, Duncan PW, Storer TW, Gazarian P, Allore HG, Dziura J, Esserman D, Carnie MB, Hanson C, Ko F, Resnick NM, Wiggins J, Lu C, Meng C, Goehring L, Fagan M, Correa-de-Araujo R, Casteel C, Peduzzi P, Greene EJ
    J Am Geriatr Soc, 2020 Oct 9, 69(1): 173-179 | PMID: 33037632 | PMCID: PMC8178516
    Citations: | AltScore: 6.6
  24. Optimizing Retention in a Pragmatic Trial of Community-Living Older Persons: The STRIDE Study.
    Gill TM, McGloin JM, Shelton A, Bianco LM, Skokos EA, Latham NK, Ganz DA, Nyquist LV, Wallace RB, Carnie MB, Dykes PC, Goehring LA, Doyle M, Charpentier PA, Greene EJ, Araujo KL
    J Am Geriatr Soc, 2020 Mar 25, 68(6): 1242-1249 | PMID: 32212395 | PMCID: PMC7707554
    Citations: 2 | AltScore: 7.05
  25. Contamination of Common Area and Rehabilitation Gym Environment with Multidrug-Resistant Organisms.
    Gontjes KJ, Gibson KE, Lansing B, Cassone M, Mody L
    J Am Geriatr Soc, 2020 Mar, 68(3): 478-485 | PMID: 31851386
    Citations: 1 | AltScore: 84.46
  26. Assessment of race and sex as risk factors for colonization with multidrug-resistant organisms in six nursing homes.
    Gontjes KJ, Gibson KE, Lansing BJ, Mody L, Cassone M
    Infect Control Hosp Epidemiol, 2020 Oct, 41(10): 1222-1224 | PMID: 32493534
    Citations: | AltScore: 6.2
  27. Detection of Real-World Trips in At-Fall Risk Community Dwelling Older Adults Using Wearable Sensors.
    Handelzalts S, Alexander NB, Mastruserio N, Nyquist LV, Strasburg DM, Ojeda LV
    Front Med (Lausanne), 2020, 7: 514 | PMID: 32984385 | PMCID: PMC7492551
    Citations: | AltScore: NA
  28. A Survey of Patient Perspectives on Approach to Health Care: Focus on Physician Competency and Compassion.
    Heinze K, Suwanabol PA, Vitous CA, Abrahamse P, Gibson K, Lansing B, Mody L
    J Patient Exp, 2020 Dec, 7(6): 1044-1053 | PMID: 33457544 | PMCID: PMC7786646
    Citations: | AltScore: 3.85
  29. Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology.
    Herrera JJ, Louzon S, Pifer K, Leander D, Merrihew GE, Park JH, Szczesniak K, Whitson J, Wilkinson JE, Fiehn O, MacCoss MJ, Day SM, Miller RA, Garratt M
    JCI Insight, 2020 Nov 5, 5(21):
    pii: 137474. | PMID: 32990683 | PMCID: PMC7710286
    Citations: | AltScore: 7.75
  30. Medication use and driving patterns in older drivers: preliminary findings from the LongROAD study.
    Hill LL, Andrews H, Li G, DiGuiseppi CG, Betz ME, Strogatz D, Pepa P, Eby DW, Merle D, Kelley-Baker T, Jones V, Pitts S
    Inj Epidemiol, 2020 Aug 3, 7(1): 38 | PMID: 32741358 | PMCID: PMC7397667
    Citations: 2 | AltScore: 1.85
  31. Prehospital and Posthospital Fall Injuries in Older US Adults.
    Hoffman GJ, Tinetti ME, Ha J, Alexander NB, Min LC
    JAMA Netw Open, 2020 Aug 3, 3(8): e2013243 | PMID: 32822491 | PMCID: PMC7439104
    Citations: | AltScore: 32
  32. Acceptability and Effects of Commercially Available Activity Trackers for Chronic Pain Management Among Older African American Adults.
    Janevic MR, Shute V, Murphy SL, Piette JD
    Pain Med, 2020 Feb 1, 21(2): e68-e78 | PMID: 31509196 | PMCID: PMC7049259
    Citations: 3 | AltScore: 6.05
  33. ResearchCOVID-19 Preparedness in Michigan Nursing Homes.
    Jones KM, Mantey J, Mills JP, Montoya A, Min L, Gibson K, Mody L
    J Am Geriatr Soc, 2020 May, 68(5): 937-939 | PMID: 32293023 | PMCID: PMC7262293
    Citations: 6 | AltScore: 96.45
  34. Exploring Representation of Diverse Samples in fMRI Studies Conducted in Patients With Cardiac-Related Chronic Illness: A Focused Systematic Review.
    Jones LM, Ginier E, Debbs J, Eaton JL, Renner C, Hawkins J, Rios-Spicer R, Tang E, Schertzing C, Giordani B
    Front Hum Neurosci, 2020, 14: 108 | PMID: 32477079 | PMCID: PMC7240043
    Citations: | AltScore: NA
  35. From molecular to macro: the key role of the apical?ligaments in uterovaginal support.
    Kieserman-Shmokler C, Swenson CW, Chen L, Desmond LM, Ashton-Miller JA, DeLancey JO
    Am J Obstet Gynecol, 2020 May, 222(5): 427-436 | PMID: 31639371 | PMCID: PMC7166152
    Citations: 1 | AltScore: 39.05
  36. Burden of perianal Staphylococcus aureus colonization in nursing home residents increases transmission to healthcare worker gowns and gloves.
    Kim JJ, Johnson JK, Stucke EM, Sorkin JD, Zhao L, Lydecker A, Mody L, Roghmann MC
    Infect Control Hosp Epidemiol, 2020 Dec, 41(12): 1396-1401 | PMID: 32762778
    Citations: | AltScore: 1
  37. Sestrins are evolutionarily conserved mediators of exercise benefits.
    Kim M, Sujkowski A, Namkoong S, Gu B, Cobb T, Kim B, Kowalsky AH, Cho CS, Semple I, Ro SH, Davis C, Brooks SV, Karin M, Wessells RJ, Lee JH
    Nat Commun, 2020 Jan 13, 11(1): 190 | PMID: 31929512 | PMCID: PMC6955242
    Citations: 9 | AltScore: 564.378
  38. Physical and Functional Impairment Among Older Adults With a History of Traumatic Brain Injury.
    Kornblith ES, Langa KM, Yaffe K, Gardner RC
    J Head Trauma Rehabil, 2020 Jul/Aug, 35(4): E320-E329 | PMID: 31996604 | PMCID: PMC7335322
    Citations: 1 | AltScore: 5.55
  39. Prevalence of Lifetime History of Traumatic Brain Injury among Older Male Veterans Compared with Civilians: A Nationally Representative Study.
    Kornblith ES, Yaffe K, Langa KM, Gardner RC
    J Neurotrauma, 2020 Dec 15, 37(24): 2680-2685 | PMID: 32762279 | PMCID: PMC7869884
    Citations: | AltScore: 5.3
  40. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
    Kowalsky AH, Namkoong S, Mettetal E, Park HW, Kazyken D, Fingar DC, Lee JH
    J Biol Chem, 2020 Feb 14, 295(7): 1769-1780 | PMID: 31915252 | PMCID: PMC7029113
    Citations: 4 | AltScore: 9.45
  41. Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals.
    Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, Thompson BA, Buchanan DD, Macrae FA, James PA, Abhayaratna WP, Lockett TJ, Gibbs P, Tonkin AM, Nelson MR, Reid CM, Woods RL, Murray AM, Winship I, McNeil JJ, Schadt E
    Genet Med, 2020 Nov, 22(11): 1883-1886 | PMID: 32606442 | PMCID: PMC7606791
    Citations: 1 | AltScore: 32.25
  42. Mild cognitive impairment and receipt of procedures for acute ischemic stroke in older adults.
    Levine DA, Galecki A, Kabeto M, Nallamothu BK, Zahuranec DB, Morgenstern LB, Lisabeth LD, Giordani B, Langa KM
    J Stroke Cerebrovasc Dis, 2020 Oct, 29(10): 105083 | PMID: 32912555 | PMCID: PMC7490756
    Citations: 1 | AltScore: NA
  43. Association of Blood Pressure and Cognition after Stroke.
    Levine DA, Galecki AT, Okullo D, Brice?o EM, Kabeto MU, Morgenstern LB, Langa KM, Giordani B, Brook R, Sanchez BN, Lisabeth LD
    J Stroke Cerebrovasc Dis, 2020 Jul, 29(7): 104754 | PMID: 32370925 | PMCID: PMC7934908
    Citations: | AltScore: NA
  44. Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals.
    Levine DA, Gross AL, Brice?o EM, Tilton N, Kabeto MU, Hingtgen SM, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Elkind MSV, Manly JJ, Moran AE, Kulick ER, Gottesman RF, Walker KA, Yano Y, Gaskin DJ, Sidney S, Yaffe K, Sacco RL, Wright CB, Roger VL, Allen NB, Galecki AT
    JAMA Neurol, 2020 Jul 1, 77(7): 810-819 | PMID: 32282019 | PMCID: PMC7154952
    Citations: 5 | AltScore: 222.798
  45. Physician decision-making and recommendations for stroke and myocardial infarction treatments in older adults with mild cognitive impairment.
    Levine DA, Langa KM, Fagerlin A, Morgenstern LB, Nallamothu BK, Forman J, Galecki A, Kabeto MU, Kollman CD, Olorode T, Giordani B, Lisabeth LD, Zahuranec DB
    PLoS One, 2020, 15(3): e0230446 | PMID: 32182264 | PMCID: PMC7077853
    Citations: 1 | AltScore: 2.75
  46. Mild Cognitive Impairment and Receipt of Treatments for Acute Myocardial Infarction in Older Adults.
    Levine DA, Langa KM, Galecki A, Kabeto M, Morgenstern LB, Zahuranec DB, Giordani B, Lisabeth LD, Nallamothu BK
    J Gen Intern Med, 2020 Jan, 35(1): 28-35 | PMID: 31410812 | PMCID: PMC6957594
    Citations: 7 | AltScore: 78.28
  47. Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.
    Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, Shuldiner AR, Lacaze P
    Clin Pharmacol Ther, 2020 Dec, 108(6): 1289-1298 | PMID: 32562573 | PMCID: PMC7959328
    Citations: | AltScore: 4
  48. Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.
    Li X, Frazier JA, Spahiu E, McPherson M, Miller RA
    Aging (Albany NY), 2020 May 28, 12(10): 8766-8789 | PMID: 32464603 | PMCID: PMC7288969
    Citations: | AltScore: 14.858
  49. Marital Status and Dementia: Evidence from the Health and Retirement Study.
    Liu H, Zhang Z, Choi SW, Langa KM
    J Gerontol B Psychol Sci Soc Sci, 2020 Sep 14, 75(8): 1783-1795 | PMID: 31251349 | PMCID: PMC7489107
    Citations: 8 | AltScore: 151.118
  50. Prescription Medication Use in Older Adults Without Major Cardiovascular Disease Enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) Clinical Trial.
    Lockery JE, Ernst ME, Broder JC, Orchard SG, Murray A, Nelson MR, Stocks NP, Wolfe R, Reid CM, Liew D, Woods RL, ASPREE Investigator Group.
    Pharmacotherapy, 2020 Oct, 40(10): 1042-1053 | PMID: 33078479 | PMCID: PMC7957955
    Citations: | AltScore: 2
  51. Potentially Preventable Hospitalizations Among Older Adults: 2010-2014.
    Mahmoudi E, Kamdar N, Furgal A, Sen A, Zazove P, Bynum J
    Ann Fam Med, 2020 Nov, 18(6): 511-519 | PMID: 33168679 | PMCID: PMC7708283
    Citations: | AltScore: 20.6
  52. Physical Activity and Falls Among a National Cohort of Older Veterans.
    Marciniak D, Alexander NB, Hoffman GJ
    J Appl Gerontol, 2020 Apr 10, 40(3): 310-319 | PMID: 32274955 | PMCID: PMC7554127
    Citations: | AltScore: 87.33
  53. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.
    Markworth JF, Brown LA, Lim E, Floyd C, Larouche J, Castor-Macias JA, Sugg KB, Sarver DC, Macpherson PC, Davis C, Aguilar CA, Maddipati KR, Brooks SV
    JCI Insight, 2020 Sep 17, 5(18):
    pii: 137713. | PMID: 32750044 | PMCID: PMC7526543
    Citations: 1 | AltScore: 18.05
  54. Feasibility and behavioral effects of prolonged static and dynamic standing as compared to sitting in older adults with type 2 diabetes mellitus.
    Marusic U, M?ller MLTM, Alexander NB, Bohnen NI
    BMC Geriatr, 2020 Jun 11, 20(1): 204 | PMID: 32527223 | PMCID: PMC7291508
    Citations: | AltScore: NA
  55. Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
    Mau T, O'Brien M, Ghosh AK, Miller RA, Yung R
    J Gerontol A Biol Sci Med Sci, 2020 Jan 1, 75(1): 89-98 | PMID: 31353414 | PMCID: PMC6909899
    Citations: 3 | AltScore: 5.85
  56. Prevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US.
    Maust DT, Strominger J, Bynum JPW, Langa KM, Gerlach LB, Zivin K, Marcus SC
    JAMA, 2020 Aug 18, 324(7): 706-708 | PMID: 32808997 | PMCID: PMC7435346
    Citations: 2 | AltScore: 294.14
  57. Canagliflozin extends life span in genetically heterogeneous male but not female mice.
    Miller RA, Harrison DE, Allison DB, Bogue M, Debarba L, Diaz V, Fernandez E, Galecki A, Garvey WT, Jayarathne H, Kumar N, Javors MA, Ladiges WC, Macchiarini F, Nelson J, Reifsnyder P, Rosenthal NA, Sadagurski M, Salmon AB, Smith DL Jr, Snyder JM, Lombard DB, Strong R
    JCI Insight, 2020 Nov 5, 5(21):
    pii: 140019. | PMID: 32990681 | PMCID: PMC7710304
    Citations: | AltScore: 21.45
  58. Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli Infections in Metro Detroit: Early Dominance of the ST-131 Clone.
    Mills JP, Kaye KS, Evans R, Salzman E, Pogue J, Hayakawa K, Marchaim D, Awasthy P, Salim M, Martin ET
    Infect Dis Ther, 2020 Sep, 9(3): 683-690 | PMID: 32683600 | PMCID: PMC7452991
    Citations: | AltScore: NA
  59. COVID-19 in older adults: clinical, psychosocial, and public health considerations.
    Mills JP, Kaye KS, Mody L
    JCI Insight, 2020 May 21, 5(10):
    pii: 139292. | PMID: 32302293 | PMCID: PMC7259511
    Citations: 8 | AltScore: 70.93
  60. On the importance of the hip abductors during a clinical one legged balance test: A theoretical study.
    Mirshams Shahshahani P, Ashton-Miller JA
    PLoS One, 2020, 15(11): e0242454 | PMID: 33186397 | PMCID: PMC7665826
    Citations: | AltScore: NA
  61. Partnering with Local Hospitals and Public Health to Manage COVID-19 Outbreaks in Nursing Homes.
    Montoya A, Jenq G, Mills JP, Beal J, Diviney Chun E, Newton D, Gibson K, Mantey J, Hurst K, Jones K, Mody L
    J Am Geriatr Soc, 2020 Oct 9, 69(1): 30-36 | PMID: 33034039 | PMCID: PMC7675453
    Citations: 4 | AltScore: 95.81
  62. Age and gender differences in the association between body mass index and all-cause mortality among older Japanese.
    Murayama H, Liang J, Shaw BA, Botoseneanu A, Kobayashi E, Fukaya T, Shinkai S
    Ethn Health, 2020 Aug, 25(6): 874-887 | PMID: 29726279
    Citations: 1 | AltScore: 10.25
  63. Association of Physical Function With Driving Space and Crashes Among Older Adults.
    Ng LS, Guralnik JM, Man C, DiGuiseppi C, Strogatz D, Eby DW, Ryan LH, Molnar LJ, Betz ME, Hill L, Li G, Crowe CL, Mielenz TJ
    Gerontologist, 2020 Jan 24, 60(1): 69-79 | PMID: 30624694 | PMCID: PMC7317610
    Citations: 3 | AltScore: 2.35
  64. Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial.
    Orchard SG, Lockery JE, Gibbs P, Polekhina G, Wolfe R, Zalcberg J, Haydon A, McNeil JJ, Nelson MR, Reid CM, Kirpach B, Murray AM, Woods RL, ASPREE Investigator Group.
    Contemp Clin Trials, 2020 Sep, 96: 106095 | PMID: 32739494 | PMCID: PMC8009087
    Citations: | AltScore: 1.25
  65. Evaluation of Racial Disparities in Hospice Use and End-of-Life Treatment Intensity in the REGARDS Cohort.
    Ornstein KA, Roth DL, Huang J, Levitan EB, Rhodes JD, Fabius CD, Safford MM, Sheehan OC
    JAMA Netw Open, 2020 Aug 3, 3(8): e2014639 | PMID: 32833020 | PMCID: PMC7445597
    Citations: 3 | AltScore: 135.65
  66. Holistic Characterization of Single Hepatocyte Transcriptome Responses to High Fat Diet.
    Park SR, Cho CS, Xi J, Kang HM, Lee JH
    Am J Physiol Endocrinol Metab, 2020 Oct 26, 320(2): E244-E258 | PMID: 33103450
    Citations: 1 | AltScore: 11.05
  67. Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage.
    Park SR, Namkoong S, Friesen L, Cho CS, Zhang ZZ, Chen YC, Yoon E, Kim CH, Kwak H, Kang HM, Lee JH
    Cell Rep, 2020 Aug 25, 32(8): 108077 | PMID: 32846134 | PMCID: PMC7486130
    Citations: 3 | AltScore: 80.546
  68. PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking.
    Penke LR, Speth JM, Draijer C, Zaslona Z, Chen J, Mancuso P, Freeman CM, Curtis JL, Goldstein DR, Peters-Golden M
    Life Sci Alliance, 2020 Nov, 3(11):
    pii: e202000800. | PMID: 32820026 | PMCID: PMC7441521
    Citations: | AltScore: 4.1
  69. Multiple Chronic Conditions in Spousal Caregivers of Older Adults With Functional Disability: Associations With Caregiving Difficulties and Gains.
    Polenick CA, Leggett AN, Webster NJ, Han BH, Zarit SH, Piette JD
    J Gerontol B Psychol Sci Soc Sci, 2020 Jan 1, 75(1): 160-172 | PMID: 29029293 | PMCID: PMC6909432
    Citations: 8 | AltScore: 18.686
  70. Medical Comorbidities of Dementia: Links to Caregivers' Emotional Difficulties and Gains.
    Polenick CA, Min L, Kales HC
    J Am Geriatr Soc, 2020 Mar, 68(3): 609-613 | PMID: 31746461 | PMCID: PMC7354235
    Citations: 1 | AltScore: 10.35
  71. A novel geriatric assessment tool that predicts postoperative complications in older adults with cancer.
    Pollock Y, Chan CL, Hall K, Englesbe M, Diehl KM, Min L
    J Geriatr Oncol, 2020 Jun, 11(5): 866-872 | PMID: 31699673 | PMCID: PMC7196495
    Citations: 1 | AltScore: 0.25
  72. Brain Protein Synthesis Rates in the UM-HET3 Mouse Following Treatment With Rapamycin or Rapamycin With Metformin.
    Reid JJ, Linden MA, Peelor FF, Miller RA, Hamilton KL, Miller BF
    J Gerontol A Biol Sci Med Sci, 2020 Jan 1, 75(1): 40-49 | PMID: 30864661 | PMCID: PMC7175973
    Citations: 6 | AltScore: 3.6
  73. Baseline characteristics and age-related macular degeneration in participants of the \ASPirin in Reducing Events in the Elderly\ (ASPREE)-AMD trial.
    Robman LD, Phuong Thao LT, Guymer RH, Wolfe R, Woods RL, Hodgson LA, Phung J, Makeyeva GA, Le-Pham YA, Orchard SG, Suleiman J, Maguire E, Trevaks RE, Ward SA, Riaz M, Lacaze P, Storey E, Abhayaratna WP, Nelson MR, Ernst ME, Reid CM, McNeil JJ, ASPREE Investigator Group.
    Contemp Clin Trials Commun, 2020 Dec, 20: 100667 | PMID: 33210016 | PMCID: PMC7658662
    Citations: | AltScore: NA
  74. Weight Loss Improves ?-Cell Function in People With Severe Obesity and Impaired Fasting Glucose: A Window of Opportunity.
    Rothberg AE, Herman WH, Wu C, IglayReger HB, Horowitz JF, Burant CF, Galecki AT, Halter JB
    J Clin Endocrinol Metab, 2020 Apr 1, 105(4):
    pii: dgz189. | PMID: 31720686 | PMCID: PMC7059991
    Citations: | AltScore: 19.85
  75. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos.
    Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E, behalf of the ASPREE Investigator Group on.
    J Alzheimers Dis Rep, 2020 Aug 4, 4(1): 313-323 | PMID: 33024939 | PMCID: PMC7504980
    Citations: 1 | AltScore: 10
  76. Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis.
    Shcherbina A, Larouche J, Fraczek P, Yang BA, Brown LA, Markworth JF, Chung CH, Khaliq M, de Silva K, Choi JJ, Fallahi-Sichani M, Chandrasekaran S, Jang YC, Brooks SV, Aguilar CA
    Cell Rep, 2020 Jul 28, 32(4): 107964 | PMID: 32726628 | PMCID: PMC8025697
    Citations: 2 | AltScore: 36
  77. Translational control in aging and neurodegeneration.
    Skariah G, Todd PK
    Wiley Interdiscip Rev RNA, 2020 Sep 20, 12(4): e1628 | PMID: 32954679 | PMCID: PMC7979572
    Citations: | AltScore: 27.4
  78. Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.
    Strong R, Miller RA, Bogue M, Fernandez E, Javors MA, Libert S, Marinez PA, Murphy MP, Musi N, Nelson JF, Petrascheck M, Reifsnyder P, Richardson A, Salmon AB, Macchiarini F, Harrison DE
    Aging Cell, 2020 Nov, 19(11): e13269 | PMID: 33145977 | PMCID: PMC7681050
    Citations: 3 | AltScore: 33.58
  79. CD73 Promotes Age-Dependent Accretion of Atherosclerosis.
    Sutton NR, Bou?s D, Mann KM, Rashid IM, McCubbrey AL, Hyman MC, Goldstein DR, Mei A, Pinsky DJ
    Arterioscler Thromb Vasc Biol, 2020 Jan, 40(1): 61-71 | PMID: 31619062 | PMCID: PMC7956240
    Citations: 4 | AltScore: 12.9
  80. The Relationship between in-Vehicle Technologies and Self-Regulation among Older Drivers.
    Svancara AM, Villavicencio L, Kelley-Baker T, Horrey WJ, Molnar LJ, Eby DW, Mielenz TJ, Hill L, DiGuiseppi C, Strogatz D, Li G
    Geriatrics (Basel), 2020 Apr 16, 5(2):
    pii: E23. | PMID: 32316266 | PMCID: PMC7344904
    Citations: 1 | AltScore: 5.08
  81. Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature.
    Tyrrell DJ, Blin MG, Song J, Wood SC, Goldstein DR
    J Am Heart Assoc, 2020 Dec, 9(23): e017820 | PMID: 33225820 | PMCID: PMC7763766
    Citations: 2 | AltScore: 24.658
  82. Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis.
    Tyrrell DJ, Blin MG, Song J, Wood SC, Zhang M, Beard DA, Goldstein DR
    Circ Res, 2020 Jan 31, 126(3): 298-314 | PMID: 31818196 | PMCID: PMC7006722
    Citations: 8 | AltScore: 68.7
  83. Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity.
    Varghese M, Griffin C, McKernan K, Eter L, Abrishami S, Singer K
    Aging (Albany NY), 2020 Jan 26, 12(2): 1725-1746 | PMID: 31983693 | PMCID: PMC7053605
    Citations: 1 | AltScore: NA
  84. Investigating the birth-related caudal maternal pelvic floor muscle injury: The consequences of low cycle fatigue damage.
    Vila Pouca MCP, Parente MPL, Natal Jorge RM, Ashton-Miller JA
    J Mech Behav Biomed Mater, 2020 Oct, 110: 103956 | PMID: 32957249
    Citations: | AltScore: NA
  85. Gut microbiota features on nursing home admission are associated with subsequent acquisition of antibiotic resistant organism colonization.
    Wang J, Cassone M, Gibson K, Lansing B, Mody L, Snitkin ES, Rao K
    Clin Infect Dis, 2020 Jun 1, 71(12): 3244-3247
    pii: ciaa662. | PMID: 32478813 | PMCID: PMC7819526
    Citations: 1 | AltScore: 3.75
  86. Application of Combined Genomic and Transfer Analyses to Identify Factors Mediating Regional Spread of Antibiotic-resistant Bacterial Lineages.
    Wang J, Foxman B, Pirani A, Lapp Z, Mody L, Snitkin ES
    Clin Infect Dis, 2020 Dec 17, 71(10): e642-e649 | PMID: 32239131 | PMCID: PMC7745002
    Citations: | AltScore: 15.25
  87. Multimorbidity and Cognitive Decline Over 14 Years in Older Americans.
    Wei MY, Levine DA, Zahodne LB, Kabeto MU, Langa KM
    J Gerontol A Biol Sci Med Sci, 2020 May 22, 75(6): 1206-1213 | PMID: 31173065 | PMCID: PMC7243582
    Citations: 16 | AltScore: 77.38
  88. Comprehensive review of ICD-9 code accuracies to measure multimorbidity in administrative data.
    Wei MY, Luster JE, Chan CL, Min L
    BMC Health Serv Res, 2020 Jun 1, 20(1): 489 | PMID: 32487087 | PMCID: PMC7268621
    Citations: 1 | AltScore: NA
  89. Multimorbidity in Medicare Beneficiaries: Performance of an ICD-Coded Multimorbidity-Weighted Index.
    Wei MY, Ratz D, Mukamal KJ
    J Am Geriatr Soc, 2020 May, 68(5): 999-1006 | PMID: 31917465 | PMCID: PMC7234913
    Citations: 3 | AltScore: 5.4
  90. No Modulation of the Effect of Aspirin by Body Weight in Healthy Older Men and Women.
    Woods RL, Polekhina G, Wolfe R, Nelson MR, Ernst ME, Reid CM, Shah RC, Lockery JE, Orchard SG, Murray AM, McNeil JJ, ASPREE Investigator Group?.
    Circulation, 2020 Mar 31, 141(13): 1110-1112 | PMID: 32223674 | PMCID: PMC7286412
    Citations: | AltScore: 10.1
  91. Self-reported Vision Impairment and Subjective Well-being in Older Adults: A Longitudinal Mediation Analysis.
    Xiang X, Freedman VA, Shah K, Hu RX, Stagg BC, Ehrlich JR
    J Gerontol A Biol Sci Med Sci, 2020 Feb 14, 75(3): 589-595 | PMID: 31169894 | PMCID: PMC7328199
    Citations: 3 | AltScore: 4.7
  92. Internet-delivered cognitive behavioral therapies for late-life depressive symptoms: a systematic review and meta-analysis.
    Xiang X, Wu S, Zuverink A, Tomasino KN, An R, Himle JA
    Aging Ment Health, 2020 Aug, 24(8): 1196-1206 | PMID: 30913898 | PMCID: PMC7529149
    Citations: 4 | AltScore: 3.75
  93. Association of Statin Use With Disability-Free Survival and Cardiovascular Disease Among Healthy Older Adults.
    Zhou Z, Ofori-Asenso R, Curtis AJ, Breslin M, Wolfe R, McNeil JJ, Murray AM, Ernst ME, Reid CM, Lockery JE, Woods RL, Tonkin AM, Nelson MR
    J Am Coll Cardiol, 2020 Jul 7, 76(1): 17-27 | PMID: 32616158 | PMCID: PMC7967891
    Citations: 2 | AltScore: 74.8
  94. Is social capital protective against hospital readmissions?
    Zlotnick H, Hoffman GJ, Nuliyalu U, Engler TA, Langa KM, Ryan AM
    BMC Health Serv Res, 2020 Mar 24, 20(1): 248 | PMID: 32209077 | PMCID: PMC7092426
    Citations: | AltScore: 8.5


Kenneth Schmader
Duke University
Serving since 2017 (4 years)

Alex Smith
San Francisco VA Medical Center
Serving since 2021 (0 years)

Rozalyn Anderson
University of Wisconsin
Serving since 2021 (0 years)

Henry Paulson (2020)
  • 2016 elected Fellow in the American Association for the Advancement of Sciences
  • American Academy of Neurology Annual Movement Disorders Research Award, 2020
  • NINDS Landis 2020 Outstanding Mentor Award


General Brief Description of Minority Activities:

Minority Research:  List activities with minority trainees and research focusing on hypotheses dealing with minority health. Clinical research that has an expected number of minority subjects (a NIH requirement) is NOT what is desired for this section. Only work that has a comparison of minority members to majority members such as work on health disparities should be included.                                                                                                                                      

Research Articles:


Acosta-Sojo, Y., & Martin, B. J. (2021). Age-related differences in proprioceptive asymmetries. Neurosci Lett, 2021 Jul 13;757:135992.

Briceño EM, Mehdipanah R, Gonzales X, Heeringa S, Levine DA, Langa KM, Garcia N, Longoria R, Morgenstern LB. Methods and Early Recruitment of a Community-Based Study of Cognitive Impairment Among Mexican Americans and Non-Hispanic Whites: The BASIC-Cognitive Study. J Alzheimers Dis. 2020;73(1):185-196. doi: 10.3233/JAD-190761. PMCID: PMC7282317.

Briceño EM, Mehdipanah R, Gonzales XF, Heeringa SG, Levine DA, Langa KM, Zahs D, Garcia N, Longoria R, Morgenstern LB. Bilingualism, assessment language, and the Montreal Cognitive Assessment in Mexican Americans. J Am Geriatr Soc. 2021 May 7. doi: 10.1111/jgs.17209. Epub ahead of print. PMID: 33963535.

Briceño EM, Mehdipanah R, Gonzales XF, Langa KM, Levine DA, Garcia NM, Longoria R, Giordani BJ, Heeringa SG, Morgenstern LB. Neuropsychological assessment of mild cognitive impairment in Latinx adults: A scoping review. Neuropsychology. 2020 Jul;34(5):493-510. doi: 10.1037/neu0000628. Epub 2020 Apr 13. PMID: 32281811; PMCID: PMC8209654.

Gontjes KJ, Gibson KE, Lansing BJ, Mody L, Cassone M. Assessment of race and sex as risk factors for colonization with multidrug-resistant organisms in six nursing homes. Infect Control Hosp Epidemiol. 2020 Oct;41(10):1222-1224. doi: 10.1017/ice.2020.215. Epub 2020 Jun 4. PMID: 32493534

Hawkins JM. Type 2 Diabetes Self-Management in Non-Hispanic Black Men: a Current State of the Literature. Curr Diab Rep. 2019 Feb 11;19(3):10. doi: 10.1007/s11892-019-1131-8. PMID: 30741346.

Hawkins, J., Gilcher, K., Schwenzer, C., & Lutz, L. Investigating Racial Differences Among Men in COVID-19 Diagnosis, and related Psychosocial and Behavioral Factors: Data from the Michigan Men’s Health Fair. Int. J. Environ. Res. Public Health. 2021:18, 3284. doi: 10.3390/ijerph18063284

Hawkins JM, Schwenzer C, Hecht HK, Jones L, Velez-Ortiz D, Lee J, Ahmedani B, Piatt G. Mental health care use in men with comorbid diabetes and depression: The role of age and race. Health Educ Care. 2019 Oct;4(3):10.15761/hec.1000163. doi: 10.15761/hec.1000163. Epub 2019 Oct 1.  PMCID: PMC8049769.

Hawkins, J., Kloss, K., Schwenzer, C., Smith, F., Nwankwo, R., Funnell, M, & Piatt, G. Michigan Men’s Diabetes Project (MenD): Protocol for a Peer Led Diabetes Self-Management with African American men with type 2 diabetes. BMC Public Health. 2021: 21(1):1-12. doi: 10.1186/s12889-021-10613-2

Janevic MR, Shute V, Murphy SL, Piette JD. Acceptability and Effects of Commercially Available Activity Trackers for Chronic Pain Management Among Older African American Adults. Pain Med. 2020 Feb 1;21(2):e68-e78. doi: 10.1093/pm/pnz215. PMID: 31509196; PMCID: PMC7049259.

Jones, LM, Ginier, E., Debbs,J. Eaton, J., Renner, C., Hawkins, J., Rios-Spicer, R., Tang, E., Schertzing, C., Giordani BM. (2020) Exploring Representation of Diverse Samples in fMRI Studies Conducted in Patients with Cardiac-Related Chronic Illness: A Focused Review. Front Hum Neurosci. 2020 May 14:108. doi: 0.3389/fnhum.2020.00108

Levine DA, Galecki AT, Langa KM, Unverzagt FW, Kabeto MU, Giordani B, Cushman M, McClure LA, Safford MM, Wadley VG.  Blood Pressure and Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White Americans. Hypertension. 2019 Feb;73(2):310-318. doi: 10.1161/HYPERTENSIONAHA.118.12062.PMID: 30624986 .

Levine DA, Gross AL, Briceño EM, Tilton N, Kabeto MU, Hingtgen SM, Giordani BJ, Sussman JB, Hayward RA, Burke JF, Elkind MSV, Manly JJ, Moran AE, Kulick ER, Gottesman RF, Walker KA, Yano Y, Gaskin DJ, Sidney S, Yaffe K, Sacco RL, Wright CB, Roger VL, Allen NB, Galecki AT. Association Between Blood Pressure and Later-Life Cognition Among Black and White Individuals. JAMA Neurol. 2020 Jul 1;77(7):810-819. doi: 10.1001/jamaneurol.2020.0568.PMID: 32282019

Mehdipanah R, Briceño EM, Gonzales XF, Heeringa SG, Levine DA, Langa KM, Garcia N, Longoria R, Morgenstern LB. Dementia care needs for individuals and caregivers among Mexican Americans and non-Hispanic Whites. Aging Ment Health. 2021 Jun 7:1-12. doi: 10.1080/13607863.2021.1925222. Epub ahead of print. PMID: 34096422.

Mitchell, J., Hawkins, J., & Burkmeier, S. (2019). Decoding the role of companions in supporting the health communication of older African American men with cancer. J Patient Exp 2020 Jun;7(3):324-330. doi: 10.1177/2374373519844098 PMCID: PMC7410131

Pettee Gabriel K, Karvonen-Gutierrez CA, Colvin AB, Ylitalo KR, Whitaker KM, Lange-Maia BS, Lucas AR, Dugan SA, Derby C, Cauley JA, Sternfeld B. Associations of accelerometer-determined sedentary behavior and physical activity with physical performance outcomes by race/ethnicity in older women. Prev Med Rep. 2021 May 19;23:101408. doi: 10.1016/j.pmedr.2021.101408. PMID: 34123715; PMCID: PMC8173313.

Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E; behalf of the ASPREE Investigator Group on. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos. J Alzheimers Dis Rep. 2020 Aug 4;4(1):313-323. doi: 10.3233/ADR-200194. PMID: 33024939;  PMCID: PMC7504980

Sternfeld B, Colvin A, Stewart A, Appelhans BM, Cauley JA, Dugan SA, El Khoudary SR, Greendale GA, Strotmeyer E, Karvonen-Gutierrez C.  Understanding Racial/Ethnic Disparities in Physical Performance in Mid-Life Women: Findings from SWAN (Study of Women's Health Across the Nation)   J Gerontol B Psychol Sci Soc Sci.  2019 Aug 14;gbz103. doi: 10.1093/geronb/gbz103. PMID: 31412129  767 

Stewart A, Sternfeld B, Lange-Maia B, Ylitalo K, Colvin A, Karvonen-Gutierrez CA, Dugan SA, Green RR, Pettee Gabriel K  Reported and device-based physical activity by race/sex groups in young-old women  . J. Meas. Phys. Behav. 2020:3 (2), 118–127  doi:   911 

Minority Trainee(s):
  • Emily Briceño-Abreau, PhD, Assistant Professor, Physical Medicine and Rehabilitation
    Emily Briceño-Abreau, PhD, Assistant Professor, Physical Medicine and Rehabilitation, is supported by the REC. Her research focus is on the measurement of cognition across language and education among Mexican American and non-Hispanic white older adults
  • Jaclynn Hawkins, Ph.D. , Assistant Professor, University of Michigan School of Social Work, Associate Director of the Gender and Health Research Lab’
    REC & PESC Recipient 2020 Type 2 Diabetes Self-Management in Older African American Men: A Peer Leader Pilot Intervention
  • Yadrianna Acosta-Sojo, PhD, Postdoctoral Research Fellow, Center for Ergonomics, Industrial and Operational Engineering
    Yadrianna Acosta-Sojo, PhD., Postdoctoral Research Fellow, Center for Ergonomics, Industrial and Operational Engineering, received support from HSAC in her research on upper limb proprioceptive systems relevant to older adults’ performance of daily activities.

Minority Grant(s):