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Hot Findings in Research View More

Functional Decline in Patients with Cirrhosis Awaiting Liver Transplantation: Results from the Functional Assessment in Liver Transplantation (FrAILT) Study.
This study examined the usefulness of geriatric measures of functional status such as the SPPB in assessing clinical status of patients on the liver transplant wait list. Measures such as the SPPB declined while patients were on the wait list, and the amount of decline strongly predicted wait list mortality, independent of measures of liver disease severity such as the MELD. The study supports the use of functional status measures such as the SPPB in monitoring the status of liver transplant candidates. Jennifer Lai is a UCSF OIAC career development scholar and Ken Covinsky is UCSF OAIC PI.

Increase in Disability Prevalence Before Hip Fracture.
This study used the Health and Retirement Study to examine changes in functional status in the 2 years preceding hip fracture in older persons. The study showed marked declines in functional status starting about 10 months before hip fracture. The results provide strong evidence that a substantial component of the poor functional outcomes observed in hip fracture patients is explained by factors other than the hip fracture. All authors are UCSF OIAC investigators. First author Alex Smith is a UCSF OAIC career development scholar.

Time to benefit for colorectal cancer screening: survival meta-analysis of flexible sigmoidoscopy trials
Tang V, Boscardin WJ, Stijacic-Cenzer I, Lee SJ.

Functional Outcomes After Lower Extremity Revascularization in Nursing Home Residents: A National Cohort Study.
Oresanya L, Zhao S, Gan S, Fries BE, Goodney PP, Covinsky KE, Conte MS, Finlayson E.

Outcomes after Breast Cancer Surgery among Nursing Home Residents in the US
Emily Finlayson, MD, MS

Functional Assessment in Liver Transplantation
Jennifer Lai, MD American Journal Paper | 2014

Exercise and Nutrition to Target Protein Synthesis Impairments in Aging Skeletal Muscle
To what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia. Exercise and Sport Sciences Reviews | October, 2013

Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults With Knee Osteoarthritis
Shifting Focus From the Heart to Peripheral Skeletal Muscle* JAMA | September 25, 2013 | Volume 310, Number 12

Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
The IDEA Randomized Clinical Trial Journal of the American College of Cardiology | Vol. 60, No. 2, 2012

Effect of Endurance Training on the Determinants of Peak Exercise Oxygen Consumption in Elderly Patients With Stable Compensated Heart Failure and Preserved Ejection Fraction Journal of the American College of Cardiology | Vol. 60, No. 2, 2012

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