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Integrated Aging Studies Databank and Repository (IASDR)

Objective:

The overall goal of the Pepper Center Integrated Aging Studies Databank and Repository (IASDR) is to guarantee the proper collection, transfer, and central storage of biological tissue (e.g., blood, skeletal muscle, adipose tissue, cartilage and DNA) to be used for conducting future ancillary studies by investigators with an interest in aging-related research.

Specimen Inventory:

As of May 2012 the Repository holds >135,000 cryovials of serum or plasma collected from >3100 research participants enrolled in 29 different studies. The Repository also has >1260 DNA samples collected from research participants. The table below lists the available samples and a brief description of the participants from each of the studies.

All samples are collected from study participants enrolled in research protocols at Wake Forest University, Wake Forest University Health Sciences, or other collaborating institutions. Written informed consent is obtained from each participant providing permission to have their samples stored for future, undesignated research. All samples are stored in labeled cryovials in -80oC freezers located in a locked room on the E floor of the Nutrition Research Building at WFUHS. The freezers are connected to an emergency power supply and a CO2 back-up system.

Requisition of Samples:

  • Only investigators (both within and outside WFUHS) with IRB-approved ancillary study proposals will be provided samples from the repository for analyses
  • Investigators who wish to use any of the samples should complete the WFU Pepper Biological Specimen Request Form and fax it, along with a copy of the IRB-approved protocol, to the Repository Coordinator, (336) 713-7059
  • All samples are identified by a unique ID which is linked to personal identifiers and other study-related data that are maintained only by the individual study’s Principal Investigator. Thus, investigators who wish to utilize samples for ancillary research will need to involve and collaborate with the PI and investigators of the original study
  • Samples will be released to investigators de-identified (as defined by the HIPAA Privacy Rule) to protect the privacy and confidentiality of study subjects

Contact the Specimen Repository Coordinator, at (336) 713-7126 for additional information.

Study (PI) Gender/Age Disease/Condition N= Study Design Intervention Serum EDTA plasma Urine Muscle Adipose DNA
REACT II (BERRY) M/F: 37-95 COPD 200 12-month RCT Aerobic Exercise;    
REACT III (BERRY) M/F: 45-80 COPD 32 4-month RCT Resistance Exercise vs. Control    
Vitamin D Supplement
(HOUSTON)
M/F: 70-89 Vitamin D insufficient 26 4-month RCT Vitamin D  + Calcium supplementation vs. calcium only      
FLOW (HUNDLEY) M/F: 50+ Aging/Heart Failure 30 Cross-sectional N/A       ?    
Predict (HUNDLEY) M/F: 55-85 At risk for CHF 608 Longitudinal cohort N/A        
Non-human Primate Sample
(KAPLAN)
F:   96   Diet - Soy and Casein; surgery-induced menopause        
Healthy Aging (KITZMAN) M/F: 60+ Healthy 61 Cross-sectional N/A          
PIE (KITZMAN) M/F: 60+ Diastolic heart failure 80 12-month RCT ACE inhibitor use vs Placebo    
PIE II (KITZMAN) M/F: 60+ Diastolic heart failure 80 12-month RCT Spironolactone vs Placebo    
SECRET (KITZMAN) M/F: 60+ Overweight/obese; heart failure 100 5-month RCT Caloric Restriction vs. Aerobic Exercise vs. CR+AEX      
LIFE - Pilot (KRITCHEVSKY) M/F: 70-89 At risk for disability 424 12-month RCT Aerobic + Resistive Exercise vs. Control      
OPTIMA (KRITCHEVSKY) M/F: 65-79 Overweight/obese; at risk for disability 88 6-month RCT Caloric Restriction + Pioglitazone vs. CR + Resistance Exercise      
RAINS (KRITCHEVSKY) M/F: 65-85 Overweight/obese; at risk for disability 67 4-month intervention Nutrition (protein) supplementation        
POWER (MARSH) M/F: 65+ At risk for disability 45 3-month RCT Strength training vs. Power training vs. Control      
IDEA (MESSIER) M/F: 55+ Overweight/obese; Knee OA 450 18-month RCT Caloric Restriction vs. Aerobic Exercise vs. CR+AEX    
LOSE-IT (MILLER) M/F: 18+ Bariatric surgery patients 42 Cross-sectional N/A    
PACT (MILLER) M/F: 60+ Overweight/obese; Knee OA 84 6-month RCT Caloric Restriction + Exercise vs. Control    
EFFECT - Pilot (MORRIS) M/F: 18+ ICU patients 100 Cross-sectional Intensive physical therapy vs. Usual Care      
TARGETT (MORRIS) M/F: 18+ ICU patients 322 RCT Intensive physical therapy vs. Usual Care      
DEMO (NICKLAS) F: 50-70 Abdominal obesity 112 5-month RCT Caloric Restriction  vs. CR + Aerobic Exercise    
I'M FIT (NICKLAS) M/F: 65-79 Obese; at risk for disability 130 5-month RCT Resistance Exercise vs. Resistance exercise + Caloric Restriction    
INFINITE (NICKLAS) M/F: 65-79 Obese 180 5-month RCT Aerobic Exercise vs AEX + Caloric Restriction        
CLIP (REJESKI) M/F: 60-79 Overweight/obese; CVD or METs 288 18-month RCT Caloric Restriction and/or Aerobic Exercise